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8 p, 2.5 MB Protein-Corona-by-Design in 2D : A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines / Mei, Kuo‐Ching (King's College London) ; Ghazaryan, Artur (Max Planck Institute for Polymer Research) ; Teoh, Er Zhen (King's College London) ; Summers, Huw D. (Swansea University) ; Li, Yueting (Guizhou Medical University) ; Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ; Piasecka, Justyna (Swansea University) ; Walters, Adam (King's College London) ; Hider, Robert C. (King's College London) ; Mailänder, Volker (Johannes Gutenberg-University. Department of Dermatology) ; Al-Jamal, Khuloud T. (King's College London)
Hard corona (HC) protein, i. e. , the environmental proteins of the biological medium that are bound to a nanosurface, is known to affect the biological fate of a nanomedicine. Due to the size, curvature, and specific surface area (SSA) 3-factor interactions inherited in the traditional 3D nanoparticle, HC-dependent bio–nano interactions are often poorly probed and interpreted. [...]
2018 - 10.1002/adma.201802732
Advanced materials, Vol. 30, Issue 40 (October 2018) , art. 1802732  

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