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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 -  10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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0 p, 3.6 MB |
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
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Rohde, David (Massachusetts General Hospital and Harvard Medical School) ;
Vandoorne, Katrien (Massachusetts General Hospital and Harvard Medical School) ;
Lee, I-Hsiu (Department of Radiology, Massachusetts General Hospital) ;
Grune, Jana (Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ;
Zhang, Shuang (Department of Radiology, Massachusetts General Hospital) ;
McAlpine, Cameron S. (Department of Radiology, Massachusetts General Hospital) ;
Schloss, Maximilian J. (Department of Radiology, Massachusetts General Hospital) ;
Nayar, Ribhu (Department of Radiology, Massachusetts General Hospital) ;
Courties, Gabriel (Department of Radiology, Massachusetts General Hospital) ;
Frodermann, Vanessa (Department of Radiology, Massachusetts General Hospital) ;
Wojtkiewicz, Gregory (Massachusetts General Hospital) ;
Honold, Lisa (Department of Radiology, Massachusetts General Hospital) ;
Chen, Qi (Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ;
Schmidt, Stephen (Massachusetts General Hospital) ;
Iwamoto, Yoshiko (Massachusetts General Hospital) ;
Sun, Yuan (Department of Radiology, Massachusetts General Hospital) ;
Cremer, Sebastian (Department of Radiology, Massachusetts General Hospital) ;
Hoyer, Friedrich F. (Department of Radiology, Massachusetts General Hospital) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol) ;
Ji, Fei (Department of Molecular Biology, Massachusetts General Hospital) ;
Zhou, Bin (Chinese Academy of Sciences) ;
Adams, Ralf H. (Max Planck Institute for Molecular Biomedicine (Alemanya)) ;
Wythe, Joshua D. (Department of Molecular Physiology and Biophysics, Baylor College of Medicine (Estats Units d'Amèrica)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Watanabe, Hideto (Aichi Medical University) ;
Jung, Yookyung (Massachusetts General Hospital) ;
van der Laan, Anja M. (Department of Cardiology, University of Amsterdam) ;
Piek, Jan J. (Department of Cardiology, University of Amsterdam) ;
Kfoury, Youmna (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Désogère, Pauline A. (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Vinegoni, Claudio (Department of Radiology, Massachusetts General Hospital) ;
Dutta, Partha (Department of Medicine, University of Pittsburgh School of Medicine) ;
Sadreyev, Ruslan I. (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Caravan, Peter (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Libby, Peter (Department of Medicine, Brigham and Women's Hospital) ;
Scadden, David T. (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Lin, Charles P. (Aichi Medical University) ;
Naxerova, Kamila (Department of Radiology, Massachusetts General Hospital) ;
Swirski, Filip K. (Department of Radiology, Massachusetts General Hospital) ;
Nahrendorf, Matthias (Department of Internal Medicine I, University Hospital Wuerzburg)
Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ's microvasculature is unknown. [...]
2021 - 10.1038/s44161-021-00002-8
Nature cardiovascular research, Vol. 1 (december 2021) , p. 28-44
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9 p, 1.5 MB |
Decoding empagliflozin's molecular mechanism of action in heart failure with preserved ejection fraction using artificial intelligence
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Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Spitaleri, Giosafat (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Domingo, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Revuelta-López, Elena (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Codina, Pau (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cediel, Germán (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Santiago Vacas, Evelyn (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cserkóová, Adriana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pascual-Figal, Domingo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Núñez, Julio (Hospital Clínic Universitari (València)) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
The use of sodium-glucose co-transporter 2 inhibitors to treat heart failure with preserved ejection fraction (HFpEF) is under investigation in ongoing clinical trials, but the exact mechanism of action is unclear. [...]
2021 - 10.1038/s41598-021-91546-z
Scientific reports, Vol. 11 (june 2021)
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5.
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13 p, 4.9 MB |
Head-to-head comparison of two engineered cardiac grafts for myocardial repair : From scaffold characterization to pre-clinical testing
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jorba, Ignasi (Universitat de Barcelona) ;
Segú-Vergés, Cristina (Anaxomics Biotech) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navajas, Daniel (Universitat de Barcelona) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. [...]
2018 - 10.1038/s41598-018-25115-2
Scientific reports, Vol. 8 (april 2018)
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10 p, 1.1 MB |
Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Yurista, Salva R. (Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Packer, Milton (Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas) ;
Heymans, Stephane (Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands) ;
Zannad, Faiez (Université de Lorraine. Centre d'Investigation Clinique Plurithématique) ;
Butler, Javed (Department of Medicine, University of Mississippi, Jackson, Mississippi) ;
Pascual-Figal, Domingo (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Lax, Antonio (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Núñez, Julio (Hospital Clínic Universitari (València)) ;
de Boer, Rudolf A.. (Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger (NHE)-1 co-transporter with 94. [...]
2019 - 10.1016/j.jacbts.2019.07.010
JACC: Basic to Translational Science, Vol. 4 Num. 7 (November 2019) , p. 831-840
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7.
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13 p, 3.7 MB |
A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Rudilla, F. (Centro de Medicina Regenerativa de Barcelona) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Díaz-Güemes, Idoia (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Crisóstomo, Verónica (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Sánchez-Margallo, Francisco M. (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). [...]
2016 - 10.1016/j.jacbts.2016.06.005
JACC: Basic to Translational Science, Vol. 1 (august 2016) , p. 360-372
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9 p, 1.3 MB |
Mechanisms of action of sacubitril/valsartan on cardiac remodeling : a systems biology approach
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Rudilla, F. (Institut Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. [...]
2017 - 10.1038/s41540-017-0013-4
NPJ Systems Biology and Applications, Vol. 3 (april 2017)
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9.
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10 p, 723.5 KB |
Extracellular vesicles do not contribute to higher circulating levels of soluble 1 in idiopathic dilated cardiomyopathy
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Rudilla, F. (Institut Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Ana Gámez (Institut Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ;
Revuelta López, Elena (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Soler Botija, Carolina (Institut Germans Trias i Pujol) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ;
Perea Gil, Isaac (Institut Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Llorente Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Idiopathic dilated cardiomyopathy () is a frequent cause of heart transplantation. Potentially valuable blood markers are being sought, and low-density lipoprotein receptor-related protein 1 (1) has been linked to the underlying molecular basis of the disease. [...]
2017 - 10.1111/jcmm.13211
Journal of Cellular and Molecular Medicine, Vol. 21 (may 2017) , p. 3000-3009
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