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Resultats globals: 2 registres trobats en 0.02 segons.
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Articles 2 registres trobats  
1.
16 p, 4.0 MB Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer / Ibrahim, Ali I. M. (Al-Zaytoonah University of Jordan) ; Batlle, Elisabet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sneha, Smarakan (University of Bradford) ; Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rüngeler, Till (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jha, Vibhu (University of Pisa. Department of Pharmacy) ; Tuccinardi, Tiziano (University of Pisa. Department of Pharmacy) ; Sadiq, Maria (University of York. Department of Biology) ; Frame, Fiona (University of York. Department of Biology) ; Maitland, Norman J. (University of York. Department of Biology) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pors, Klaus (University of Bradford)
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of ALDH isoforms, and here, we report on the synthesis, ALDH isoform selectivity, and cellular potencies in prostate cancer cells of 40 DEAB analogues; three analogues (14, 15, and 16) showed potent inhibitory activity against ALDH1A3, and two analogues (18 and 19) showed potent inhibitory activity against ALDH3A1. [...]
2022 - 10.1021/acs.jmedchem.1c01367
Journal of Medicinal Chemistry, Vol. 65, Issue 5 (February 2022) , p. 3833-3848  
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2.
23 p, 5.4 MB Design, synthesis, biological evaluation and in silico study of benzyloxybenzaldehyde derivatives as selective aldh1a3 inhibitors / Ibrahim, Ali I. M. (Al-Zaytoonah University of Jordan. Faculty of Pharmacy) ; Ikhmais, Balqis (Al-Zaytoonah University of Jordan. Faculty of Pharmacy) ; Batlle, Elisabet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Abuharb, Waed K. (Al-Zaytoonah University of Jordan. Faculty of Pharmacy) ; Jha, Vibhu (University of Pisa. Department of Pharmacy) ; Jaradat, Khaled T. (American University of the Middle East. College of Engineering and Technology) ; Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pors, Klaus (University of Bradford. Faculty of Life Sciences)
Aldehyde dehydrogenase 1A3 (ALDH1A3) has recently gained attention from researchers in the cancer field. Several studies have reported ALDH1A3 overexpression in different cancer types, which has been found to correlate with poor treatment recovery. [...]
2021 - 10.3390/molecules26195770
Molecules, Vol. 26 Núm. 19 (september 2021) , p. 5770  
Registre complet - Creative Commons

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