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1.
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22 p, 2.6 MB |
Clinical Features of Gastric Signet Ring Cell Cancer : Results from a Systematic Review and Meta-Analysis
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Dal Cero, Mariagiulia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bencivenga, Maria (Borgo Trento Hospital) ;
Liu, Drolaiz H. W. (Kepler University Hospital and Johannes Kepler University) ;
Sacco, Michele (Borgo Trento Hospital) ;
Alloggio, Mariella (Borgo Trento Hospital) ;
Kerckhoffs, Kelly G. P. (VieCuri Medical Centre) ;
Filippini, Federica (Borgo Trento Hospital) ;
Saragoni, Luca (Morgagni-Pierantoni Hospital) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tomezzoli, Anna (Verona University Hospital) ;
Carneiro, Fátima (Centro Hospitalar Universitário São João (Porto, Portugal)) ;
Grabsch, Heike I. (University of Leeds) ;
Verlato, Giuseppe (University of Verona) ;
Torroni, Lorena (University of Verona) ;
Piessen, Guillaume (Lille University Hospital) ;
Pera Román, Manuel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Manzoni, Giovanni (Borgo Trento Hospital) ;
Universitat Autònoma de Barcelona
The clinical behaviour of signet ring cell histology in gastric cancer has long been a subject of controversy. Recent years have underscored the pressing issue of a lack of a standardised definition for signet ring cell histology, leading to its often-ambiguous placement within broader categories associated with poor prognosis. [...]
2023 -  10.3390/cancers15215191
Cancers, Vol. 15 (october 2023)
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2.
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12 p, 3.1 MB |
Sézary syndrome patient-derived models allow drug selection for personalized therapy
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Gallardo, Fernando (Hospital del Mar (Barcelona, Catalunya)) ;
Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Arnau (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Solé Font, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Blanco, Gonzalo (Hospital del Mar (Barcelona, Catalunya)) ;
Colomo, Luis (Hospital del Mar (Barcelona, Catalunya)) ;
Gimeno, Eva (Hospital del Mar (Barcelona, Catalunya)) ;
Conde, David (Hospital del Mar (Barcelona, Catalunya)) ;
Rodríguez García, Eva (Hospital del Mar (Barcelona, Catalunya)) ;
Bielsa Marso, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya)) ;
Bellosillo Paricio, Beatriz (Hospital del Mar (Barcelona, Catalunya)) ;
Pujol Vallverdú, Ramón M (Hospital del Mar (Barcelona, Catalunya)) ;
Regueiro, José R. (Universidad Complutense de Madrid. Departamento de Microbiología y Parasitología) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques)
Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. [...]
2022 - 10.1182/bloodadvances.2021006860
Blood advances, Vol. 6 Núm. 11 (14 2022) , p. 3410-3421
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3.
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15 p, 3.2 MB |
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
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Solé Font, Laura (Instituto de Salud Carlos III) ;
Lobo-Jarne, Teresa (Instituto de Salud Carlos III) ;
Álvarez-Villanueva, Daniel (Institut Català d'Oncologia) ;
Alonso-Marañón, Josune (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guix, Marta (Universitat Pompeu Fabra) ;
Sangrador, Irene (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rozalén, Catalina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vert, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barbachano, Antonio (Universidad Autónoma de Madrid) ;
Lop Gros, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Salido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
García-Romero, Raquel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martínez-Iniesta, María (Institut Català d'Oncologia) ;
López-Arribillaga, Erika (Group of Biomedical Genomics) ;
Salazar, Ramón. (Institut Català d'Oncologia) ;
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Celià-Terrassa, Toni (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Munoz, Alberto (Instituto de Salud Carlos III) ;
Villanueva, Alberto (Institut Català d'Oncologia) ;
Bigas Salvans, Anna (Instituto de Salud Carlos III) ;
Espinosa, Lluís (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and patient outcome is primarily unstudied. [...]
2022 - 10.1038/s41467-022-30382-9
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2866
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4.
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17 p, 9.0 MB |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
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Cantero-Recasens, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso-Marañón, Josune (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lobo-Jarne, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Malhotra, Vivek (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by increasing mucins' secretion. [...]
2022 - 10.7554/eLife.73926
eLife, Vol. 11 (february 2022)
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5.
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1 p, 651.8 KB |
Publisher Correction : Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
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Cáceres, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Quesada, Rita (Hospital del Mar (Barcelona, Catalunya)) ;
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya)) ;
Real, Francisco X. (Centro Nacional de Investigaciones Oncológicas) ;
Villamonte, Maria (Hospital del Mar (Barcelona, Catalunya)) ;
de Villarreal, Jaime Martinez (Centro Nacional de Investigaciones Oncológicas) ;
Pérez, Mónica (Centro Nacional de Investigaciones Oncológicas) ;
Andaluz Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Berjano, Enrique (Universitat Politècnica de València. Departament d'Enginyeria Electrònica) ;
Dorcaratto, Dimitri (Hospital Clínic i Provincial de Barcelona) ;
Sánchez-Velázquez, Patricia (Hospital del Mar (Barcelona, Catalunya)) ;
Grande, L (Hospital del Mar (Barcelona, Catalunya)) ;
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya))
2021 - 10.1038/s41598-021-85032-9
Scientific reports, Vol. 11 (march 2021)
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6.
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13 p, 5.2 MB |
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
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López-Arribillaga, Erika (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodilla, Verónica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Colomer, Carlota (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vert, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Shelton, Amy (Genentech, Inc. Department of Discovery Oncology, South San Francisco) ;
Cheng, Jason H. (Genentech, Inc. Department of Discovery Oncology, South San Francisco) ;
Yan, Bing (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gonzalez-Perez, Abel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Junttila, Melissa R. (Genentech, Inc. Department of Translational Oncology, South San Francisco) ;
Iglesias, Mar (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Albanell Mestres, Joan (Hospital del Mar (Barcelona, Catalunya)) ;
Villanueva, Alberto (Hospital Universitari de Bellvitge) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Siebel, Christian W. (Genentech, Inc. Department of Discovery Oncology, South San Francisco) ;
Espinosa, LLuís (Institut Hospital del Mar d'Investigacions Mèdiques)
Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the Apc Min/+ mouse model, tumor spheroid cultures, and patient-derived orthoxenografts to address this divergent ligand-dependent Notch function and its implication in disease. [...]
2018 - 10.1038/s41467-018-05385-0
Nature communications, Vol. 9 (july 2018)
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7.
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12 p, 2.8 MB |
Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
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Cáceres, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Quesada, Rita (Hospital del Mar (Barcelona, Catalunya)) ;
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya)) ;
Real, Francisco X. (Centro Nacional de Investigaciones Oncológicas) ;
Villamonte, Maria (Hospital del Mar (Barcelona, Catalunya)) ;
de Villarreal, Jaime Martinez (Centro Nacional de Investigaciones Oncológicas) ;
Pérez, Mónica (Centro Nacional de Investigaciones Oncológicas) ;
Andaluz Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Berjano, Enrique (Universitat Politècnica de València. Departament d'Enginyeria Electrònica) ;
Dorcaratto, Dimitri (Hospital Clínic Universitari (València)) ;
Velazquez, Patricia Sánchez (Hospital del Mar (Barcelona, Catalunya)) ;
Grande, L (Hospital del Mar (Barcelona, Catalunya)) ;
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya))
Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. [...]
2020 - 10.1038/s41598-020-74947-4
Scientific reports, Vol. 10 (october 2020)
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8.
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17 p, 2.8 MB |
Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis
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Martínez Bosch, Neus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cristóbal, Helena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Iglesias, Mar (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Gironella, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Barranco, Luis E (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Visa, Laura (Hospital del Mar (Barcelona, Catalunya)) ;
Calafato, Domenico (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jiménez-Parrado, Silvia (Centro Nacional de Investigaciones Oncológicas) ;
Earl, Julie (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Manero-Rupérez, Noemí (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Moreno Merino, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Morales, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guerra, Carmen (Centro Nacional de Investigaciones Oncológicas) ;
Navarro, Pilar (Institut d'Investigacions Biomèdiques de Barcelona) ;
García de Frutos, Pablo (Institut d'Investigacions Biomèdiques de Barcelona)
Early diagnosis is crucial for patients with pancreatic ductal adenocarcinoma (PDAC). The AXL receptor tyrosine kinase is proteolytically processed releasing a soluble form (sAXL) into the blood stream. [...]
2021 - 10.1016/j.ebiom.2021.103797
EBioMedicine, Vol. 75 (december 2021)
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9.
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10 p, 358.9 KB |
Predictors of Metachronous Risk Polyps After Index Colonoscopy
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Carot, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Navarro Viu, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Naranjo-Hans, Dolores (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Dalmases, Alba (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernández Ibarrondo, Lierni (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Seoane, Agustín (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Buron, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bellosillo Paricio, Beatriz (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bessa Caserras, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Andreu, Montserrat (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Alvarez-Urturi, Cristina (Institut Hospital del Mar d'Investigacions Mèdiques)
We included patients with high-risk lesions (HRLs), defined as advanced adenoma (AA), large serrated polyps (SPs), and multiplicity (≥3 of any adenomas/SPs). Data on age, sex, cardiovascular risk factors, pharmacological treatment, and the histological characteristics in each individual, and mutations in genes involved in the most advanced index polyp, were collected. [...]
2021 - 10.14309/ctg.0000000000000304
Clinical and Translational Gastroenterology, Vol. 12 (february 2021)
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10.
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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