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19 p, 2.3 MB |
B Cells in Breast Cancer Pathology
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Li, Mengyuan (King's College London) ;
Quintana, Angela (Vall d'Hebron Institut d'Oncologia) ;
Alberts, Elena (The Francis Crick Institute) ;
Hung, Miu Shing (King's College London) ;
Boulat, Victoire (King's College London) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Grigoriadis, Anita (School of Cancer and Pharmaceutical Sciences) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
B cells in the tumour microenvironment and lymph nodes have affirmed their role in breast cancer pathology. Multiplex imaging, single cell, and spatial transcriptomics of cancer patients' breast carcinomas and lymph nodes have illustrated the diversity and spatial context of B cells in this disease. [...]
2023 -  10.3390/cancers15051517
Cancers, Vol. 15, Issue 5 (February 2023) , art. 1517
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25 p, 4.8 MB |
Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide
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Cámara-Sánchez, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz Riascos, Zamira Vanessa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García Aranda, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giani-Alonso, Micaela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast cancer subtype with the highest number of CSCs and the poorest prognosis. [...]
2022 - 10.3390/ijms231911760
International journal of molecular sciences, Vol. 23, Issue 19 (October 2022) , art. 11760
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36 p, 2.2 MB |
Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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Ramos-Vicente, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ji, Jie (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gratacòs-Batlle, Esther (Universitat de Barcelona) ;
Gou Alsina, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Reig-Viader, R. (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez-Martín, josé Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Burguera, Demian (Universitat de Barcelona) ;
Navas-Pérez, Enrique (Universitat de Barcelona) ;
García-Fernández, Jordi (Universitat de Barcelona) ;
Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Escrivà, Hector (Sorbonne Université) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soto, David (Universitat de Barcelona) ;
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. [...]
2018 - 10.7554/eLife.35774
eLife, Vol. 7 (november 2018)
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11 p, 1.8 MB |
Chromosomal evolution in Raphicerus antelope suggests divergent X chromosomes may drive speciation through females, rather than males, contrary to Haldane's rule
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Robinson, Terence J. (Stellenbosch University. Department of Botany and Zoology) ;
Cernohorska, Halina (Veterinary Research Institute) ;
Kubickova, Svatava (Veterinary Research Institute) ;
Vozdova, Miluse (Veterinary Research Institute) ;
Musilova, Petra (Veterinary Research Institute) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Chromosome structural change has long been considered important in the evolution of post-zygotic reproductive isolation. The premise that karyotypic variation can serve as a possible barrier to gene flow is founded on the expectation that heterozygotes for structurally distinct chromosomal forms would be partially sterile (negatively heterotic) or show reduced recombination. [...]
2021 - 10.1038/s41598-021-82859-0
Scientific reports, Vol. 11 (February 2021) , art. 3152
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7.
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2 p, 410.3 KB |
Formulacions precises i més eficaces per administrar proteïnes
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Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Carratalá, José Vicente (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Les proteïnes recombinants, molècules biològiques amb potencial terapèutic, representen un avenç en la salut humana i animal com és el cas de la insulina. Aquestes, però, un cop administrades són degradades ràpidament. [...]
Las proteínas recombinantes, moléculas biológicas con potencial terapéutico, representan un avance en la salud humana y animal como es el caso de la insulina. Estas, sin embargo, una vez administradas son degradadas rápidamente. [...]
Recombinant proteins, biological molecules with therapeutic potential, represent an advance in human and animal health as is the case of insulin. These, however, once administered are quickly degraded. [...]
2020
UAB divulga, Octubre 2020
3 documents
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8.
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37 p, 10.2 MB |
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
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Trevijano-Contador, Núria (Centro Nacional de Microbiología (Espanya)) ;
Oliveira, Haroldo César de (Universidade Estadual Paulista (UNESP). Departamento de Análises Clínicas) ;
García-Rodas, Rocío (Centro Nacional de Microbiología (Espanya)) ;
Rossi, Suélen Andreida (Centro Nacional de Microbiología (Espanya)) ;
Llorente, Irene (Centro Nacional de Microbiología (Espanya)) ;
Zaballos, Ángel (Instituto de Salud Carlos III) ;
Janbon, Guilhem (Institut Pasteur. Département de Mycologie) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Zaragoza, Óscar (Centro Nacional de Microbiología (Espanya)) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. [...]
2018 - 10.1371/journal.ppat.1007007
PLOS pathogens, Vol. 14 issue 5 (2018) , art. e1007007
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21 p, 4.1 MB |
Embedding MRI information into MRSI data source extraction improves brain tumour delineation in animal models
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Ortega-Martorell, Sandra (Liverpool John Moores University. Department of Applied Mathematics) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Thomson, Ryan (Liverpool John Moores University. Department of Applied Mathematics) ;
Riley, Patrick (Liverpool John Moores University. Department of Applied Mathematics) ;
Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Olier, Iván (Liverpool John Moores University. Department of Applied Mathematics) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Glioblastoma is the most frequent malignant intra-cranial tumour. Magnetic resonance imaging is the modality of choice in diagnosis, aggressiveness assessment, and follow-up. However, there are examples where it lacks diagnostic accuracy. [...]
2019 - 10.1371/journal.pone.0220809
PloS one, Vol. 14, Núm. 8 (2019) , art. e0220809
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17 p, 933.8 KB |
Chromosomics : bridging the gap between genomes and chromosomes
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E. Deakin, Janine (University of Canberra. Institute for Applied Ecology) ;
Potter, Sally (Australian National University) ;
O'Neill, Rachel (University of Connecticut. Institute for Systems Genomics and Department of Molecular and Cell Biology) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
B. Ciof, Marcelo (Universidade Federal de São Carlos) ;
D. B. Eldridge, Mark (Australian Museum Research Institute) ;
Fukui, Kichi (Osaka University. Graduate School of Pharmaceutical Sciences) ;
Marshall Graves, Jennifer A. (University of Canberra. Institute for Applied Ecology) ;
Griffin, Darren (University of Kent. School of Biosciences) ;
Grutzner, Frank (The University of Adelaide. School of Biological Sciences) ;
Kratochvíl, Lukáš (Charles University. Department of Ecology) ;
Miura, Ikuo (Hiroshima University. Amphibian Research Center) ;
Rovatsos, Michail (The University of Adelaide. School of Biological Sciences) ;
Srikulnath, Kornsorn (Kasetsart University. Department of Genetics, Faculty of Science) ;
Wapstra, Erik (University of Tasmania. School of Natural Sciences) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in the cell, and how chromosomes and their interactions with each other change in response to environmental stimuli or over time. [...]
2019 - 10.3390/genes10080627
Genes, Vol. 10 (2019) , p. 1-17
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