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1.
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15 p, 2.3 MB |
Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles
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Della Camera, Giacomo (European Commission. Joint Research Centre) ;
Liu, Tinghao (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Yang, Wenjie (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Li, Yang (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Gioria, Sabrina (European Commission. Joint Research Centre) ;
Italiani, Paola (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Boraschi, Diana (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation)
We assessed whether concomitant exposure of human monocytes to bacterial agents and different engineered nanoparticles can affect the induction of protective innate memory, an immune mechanism that affords better resistance to diverse threatening challenges. [...]
2022 -  10.3390/ijms232314655
International journal of molecular sciences, Vol. 23, Issue 23 (November 2022) , art. 14655
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2.
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13 p, 7.0 MB |
Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory
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Swartzwelter, Benjamin J. (Paris Lodron University of Salzburg. Department Biosciences) ;
Michelini, Sara (Paris Lodron University of Salzburg. Department Biosciences) ;
Frauenlob, Tobias (Paris Lodron University of Salzburg. Department Biosciences) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department Biosciences) ;
Horejs-Hoeck, Jutta (Paris Lodron University of Salzburg. Department Biosciences) ;
Italiani, Paola (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn)
Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. [...]
2021 - 10.3389/fimmu.2021.751683
Frontiers in immunology, Vol. 12 (Nov. 2021) , art. 751683
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3.
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20 p, 3.3 MB |
Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for endotoxin binding
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Mangini, MARIA (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Verde, Alessandro (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
De Luca, Anna Chiara (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
The interaction between engineered nanoparticles and the bacterial lipopolysaccharide, or endotoxin, is an event that warrants attention. Endotoxin is one of the most potent stimulators of inflammation and immune reactions in human beings, and is a very common contaminant in research labs. [...]
2021 - 10.1080/17435390.2021.1898690
Nanotoxicology, Vol. 15, issue 4 (2021) , p. 558-576
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4.
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20 p, 1.2 MB |
The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
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Ernst, Lena M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences) ;
Italiani, Paola (Institute of Biochemistry and Cell Biology (Nàpols, Itàlia)) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
The immune system contributes to maintaining the body's functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). [...]
2021 - 10.3390/nano11112991
Nanomaterials, Vol. 11, issue 11 (Nov. 2021) , art. 2991
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5.
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17 p, 3.1 MB |
Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA
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Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Busquets-Fité, Martí (Applied Nanoparticles S.L.) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Cesaroni, Paola (ALTA S.r.l.u) ;
Drobne, Damjana (Univerza V Ljubljani. Oddelek za biologijo) ;
Duschl, Albert (Paris-Lodron University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Gispert, Ignasi (Applied Nanoparticles S.L.) ;
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg. Department of Biosciences) ;
Italiani, Paola (Stazione Zoologica Anton Dohrn) ;
Kemmerling, Birgit (Eberhard-Karls University Tübingen. Center for Plant Molecular Biology-ZMBP) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Procházková, Petra (Institute of Microbiology of the Czech Academy of Sciences) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Understanding how engineered nanomaterials affect immune responses of living organisms requires a strong collaborative effort between immunologists, toxicologists, ecologists, physiologists, inorganic chemists, nanomaterial scientists and experts in law and risk management. [...]
2020 - 10.1039/d0en00732c
Environmental science. Nano, Vol. 7, issue 11 (Nov. 2020) , p. 3216-3232
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6.
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26 p, 2.5 MB |
Addressing nanomaterial immunosafety by evaluating innate immunity across living species
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Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Auguste, Manon (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology) ;
Hernadi, Szabolcs (Cardiff University. School of Biosciences) ;
Mayall, Craig (University of Liubljana. Department of Biology) ;
Michelini, Sara (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Navarro Pacheco, Natividad I. (Czech Academy of Sciences. Institute of Microbiology) ;
Prinelli, Alessandra (AvantiCell Science Ltd) ;
Swart, Elmer (UK Centre for Ecology and Hydrology) ;
Swartzwelter, Benjamin J. (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Drobne, Damjana (University of Liubljana. Department of Biology) ;
Duschl, Albert (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Horejs-Hoeck, Jutta (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Kemmerling, Birgit (Center for Plant Molecular Biology - ZMBP. Eberhard-Karls University Tübingen) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Prochazkova, Petra (Czech Academy of Sciences. Institute of Microbiology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. [...]
2020 - 10.1002/smll.202000598
Small, Vol. 16, issue 21 (May 2020) , art. 2000598
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7.
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17 p, 1.5 MB |
Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance
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Swartzwelter, Benjamin J. (Institute of Biochemistry and Cell Biology) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Institute of Biochemistry and Cell Biology) ;
Mangini, Maria (Institute of Biochemistry and Cell Biology) ;
Pirozzi, Marinella (Institute of Biochemistry and Cell Biology) ;
De Luca, Anna Chiara (Institute of Biochemistry and Cell Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Leite, Luciana C. C. (Instituto Butantan. Laboratório de Desenvolvimento de Vacinas) ;
Italiani, Paola (Institute of Biochemistry and Cell Biology) ;
Boraschi, Diana (Institute of Biochemistry and Cell Biology)
Innate immune memory is characterized by a modulation in the magnitude with which innate immune cells such as monocytes and macrophages respond to potential dangers, subsequent to previous exposure to the same or unrelated agents. [...]
2020 - 10.3390/cells9020284
Cells, Vol. 9, Issue 2 (February 2020) , art. 284
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8.
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13 p, 1.8 MB |
Interaction between macrophages and nanoparticles : in vitro 3d cultures for the realistic assessment of inflammatory activation and modulation of innate memory
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Swartzwelter, Benjamin (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Rehak, Laura (Athena Biomedical Innovations (Roma, Itàlia)) ;
Madej, Mariusz (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Italiani, Paola (Stazione Zoologica Anton Dohrn)
Understanding the modes of interaction between human monocytes/macrophages and engineered nanoparticles is the basis for assessing particle safety, in terms of activation of innate/inflammatory reactions, and their possible exploitation for medical applications. [...]
2021 - 10.3390/nano11010207
Nanomaterials, Vol. 11, issue 1 (Jan. 2021) , art. 207
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9.
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20 p, 3.7 MB |
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation
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Li, Yang (Hebei Normal University) ;
Shi, Zhenzhen (Kansas State University. Department of Anatomy and Physiology) ;
Radauer-Preiml, Isabella (University of Salzburg. Department of Molecular Biology) ;
Andosch, Ancuela (University of Salzburg. Department of Molecular Biology) ;
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luetz-Meindl, Ursula (University of Salzburg. Department of Molecular Biology) ;
Cobaleda-Siles, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lin, Zhoumeng (Kansas State University. Department of Anatomy and Physiology) ;
Jaberi-Douraki, Majid (Kansas State University. Department of Anatomy and Physiology) ;
Italiani, Paola (National Research Council) ;
Horejs-Hoeck, Jutta (University of Salzburg. Department of Molecular Biology) ;
Himly, Martin (University of Salzburg. Department of Molecular Biology) ;
Monteiro-Riviere, Nancy A. (Kansas State University. Department of Anatomy and Physiology) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Boraschi, Diana (National Research Council)
Nanoparticles (NPs) are easily contaminated by bacterial endotoxin (lipopolysaccharide [LPS]). The presence of LPS can be responsible for many immune/inflammatory effects attributed to NPs. In this study, we examined the effects of LPS adsorption on the NP surface on the formation of a biocorona in biological fluids and on the subsequent inflammation-inducing activity of NPs. [...]
2017 - 10.1080/17435390.2017.1401142
Nanotoxicology, Vol. 11, Issue 9-10 (December 2017) , p. 1157-1175
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10.
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21 p, 792.0 KB |
Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects
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Oostingh, G. J. (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Italiani, Paola (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Colognato, Renato (Italian Institute for Environmental Protection and Research) ;
Stritzinger, René (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Ponti, Jessica (Italian Institute for Environmental Protection and Research) ;
Pfaller, Tobias (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Kohl, Yvonne (Fraunhofer-Institut für Biomedizinische Technik) ;
Ooms, Daniëla (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Favilli, Flavia (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Leppens, Hilde (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Lucchesi, Davide (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Rossi, François (Italian Institute for Environmental Protection and Research) ;
Nelissen, Inge (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Thielecke, Hagen (Fraunhofer-Institut für Biomedizinische Technik) ;
Puntes, Víctor (Institució Catalana de Recerca i Estudis Avançats) ;
Duschl, Albert (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Boraschi, Diana (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche)
Background: With the increasing use of nanomaterials, the need for methods and assays to examine their immunosafety is becoming urgent, in particular for nanomaterials that are deliberately administered to human subjects (as in the case of nanomedicines). [...]
2011 - 10.1186/1743-8977-8-8
Particle and fibre toxicology, Vol. 8 (February 2011) , art. 8
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