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4 p, 721.0 KB |
Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain
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Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Puig, Mariona (Hospital Veterinari Sant Mori S.L) ;
Rodon, Jordi (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ;
Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cantero, Guillermo (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ;
Terrón, Maria Teresa (Hospital Veterinari Sant Mori S.L) ;
Cruz, Sílvia (Hospital Veterinari Sant Mori S.L) ;
Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol) ;
Guallar, Víctor (Catalan Institution for Research and Advanced Studies) ;
Vidal Barba, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ;
Valencia, Alfonso (Catalan Institution for Research and Advanced Studies) ;
Blanco, Ignacio (Institut Germans Trias i Pujol) ;
Blanco, Julià (Institut Germans Trias i Pujol) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol) ;
Vergara-Alert, Júlia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
COVID-19 is the most devastating pandemic in recent history. As with many emerging infectious diseases, it is of zoonotic origin, meaning that animals played a major role in the initial transmission events. [...]
2020 -  10.1073/pnas.2010817117
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117 (september 2020) , p. 24790-24793
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, M (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia Melendo, Gustavo (Institut Germans Trias i Pujol) ;
Borràs, Francesc E (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital and University of Lausanne) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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13 p, 912.5 KB |
Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans -Infection Through Recognition of Viral Membrane Gangliosides
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Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Zangger, Nadine (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ;
Erikson, Elina (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Keppler, Oliver T. (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Telenti, Amalio (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ;
Kräusslich, Hans-Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Universitat Autònoma de Barcelona
The novel dendritic cell receptor Siglec-1 binds sialyllactose moieties on HIV-1 membrane gangliosides, thereby enhancing HIV-1 transinfection. Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. [...]
2012 - 10.1371/journal.pbio.1001448
PLoS biology, Vol. 10 (december 2012)
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15 p, 2.1 MB |
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
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Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bilbao, Eneritz (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Agulló, Luis (Universitat de Vic. Departament de Biociències) ;
Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol) ;
Nieto-Garai, Jon A. (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Contreras, F. Xabier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Floor, Martin (Universitat de Vic. Departament de Biociències) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Villà-Freixa, Jordi (Universitat de Vic. Departament de Biociències) ;
Lorizate, Maier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. [...]
2017 - 10.1038/srep40800
Scientific reports (Nature Publishing Group), gener 2017, p. 1-15
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9 p, 915.2 KB |
HIV-1 Capture and Transmission by Dendritic Cells : The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
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Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Universidad del Pais Vasco. Unidad de Biofisica (CSIC-UPV/EHU) y Departamento de Bioquímica) ;
McLaren, Paul J. (University Hospital Center and University of Lausanne. Institute of Microbiology) ;
Telenti, Amalio (University Hospital Center and University of Lausanne. Institute of Microbiology) ;
Kräusslich, Hans-Georg (Universitätsklinikum Heidelberg. Department of Infectious Diseases, Virology) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Universitat Autònoma de Barcelona
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. [...]
2014 - 10.1371/journal.ppat.1004146
PLoS pathogens, Vol. 10 (july 2014)
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16 p, 1.9 MB |
The infectious synapse formed between mature dendritic cells and CD4 + T cells is independent of the presence of the HIV-1 envelope glycoprotein
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Rodriguez-Plata, Maria T (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puigdomènech, Isabel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Since cell-mediated infection of human immunodeficiency virus type 1 (HIV-1) is more efficient than cell-free infection, cell-to-cell propagation plays a crucial role in the pathogenesis of HIV-1 infection. [...]
2013 - 10.1186/1742-4690-10-42
Retrovirology, Vol. 10 (april 2013) , p. 42
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15 p, 1.4 MB |
Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ;
Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casas, Josefina (Institut de Química Avançada de Catalunya) ;
Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ;
Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)
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7 p, 617.5 KB |
Identification of Siglec-1 null individuals infected with HIV-1
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Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rotger, Margalida (University of Lausanne (Suïssa)) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ;
Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ;
Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)
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15 p, 3.1 MB |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erikson, Elina (University of Frankfurt (Alemanya)) ;
Fernández Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rausell, Antonio (University of Lausanne (Suïssa)) ;
Ciuffi, Angela (University of Lausanne (Suïssa)) ;
Keppler, Oliver T. (University of Frankfurt (Alemanya)) ;
Telenti, Amalio (University of Lausanne (Suïssa)) ;
Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x.
Retrovirology, Vol 12, article 37 (May 2015)
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13 p, 426.6 KB |
HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4
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Puigdomènech Iñiguez, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Massanella Luna, Marta, 1983- (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz Hernández, Raúl (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Curriu Martí, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bofill Soliguer, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Juan, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco Arbués, Julià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Cell-to-cell HIV transmission requires cellular contacts that may be in part mediated by the integrin leukocyte function antigen (LFA)-1 and its ligands intercellular adhesion molecule (ICAM)-1, -2 and -3. [...]
2008 - 10.1186/1742-4690-5-32
Retrovirology, Vol. 5, Núm. 32 (March 2008), p. 1-13
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