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22 p, 2.7 MB Somatic hypomethylation of pericentromeric sst1 repeats and tetraploidization in human colorectal cancer cells / González Fernández, Beatriz (Institut Germans Trias i Pujol) ; Navarro Jiménez, Maria (Institut Germans Trias i Pujol) ; Alonso De Gennaro, María José (Institut Germans Trias i Pujol) ; Jansen, Sanne Marcia (Institut Germans Trias i Pujol) ; Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Perucho, Manuel (Sanford Burnham Prebys Medical Discovery Institute (SBP)) ; Alonso, Sergio (Institut Germans Trias i Pujol)
Somatic DNA hypomethylation and aneuploidy are hallmarks of cancer, and there is evidence for a causal relationship between them in knockout mice but not in human cancer. The non-mobile pericentromeric repetitive elements SST1 are hypomethylated in about 17% of human colorectal cancers (CRC) with some 5-7% exhibiting strong age-independent demethylation. [...]
2021 - 10.3390/cancers13215353
Cancers, Vol. 13 Núm. 21 (11-1 2021) , p. 5353  

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