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9 p, 612.9 KB |
Bariatric surgery increases the rate of major fracture : self-controlled case series study in Clinical Practice Research Datalink
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Robinson, Danielle E. (University of Oxford) ;
Douglas, Ian (London School of Hygiene & Tropical) ;
Tan, Garry D. (The National Institute for Health Research (NIHR) Oxford Biomedical Research Centre) ;
Delmestri, Antonella (University of Oxford) ;
Judge, Andrew (University of Bristol) ;
Cooper, Cyrus (University of Oxford) ;
Javaid, M. Kassim (University of Southampton) ;
Strauss, Victoria Y. (University of Oxford) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
Conflicting results exist about the relationship between bariatric surgery and fracture risk. Also, prediction of who is at increased risk of fracture after bariatric surgery is not currently available. [...]
2021 -  10.1002/jbmr.4405
Journal of Bone and Mineral Research, Vol. 36 (july 2021) , p. 2153-2161
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2 p, 536.6 KB |
Correction to : Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B-5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark
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Ali, M. Sanni (Saint Paul Hospital Millennium Medical College. Department of Public Health) ;
Ernst, Martin (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ;
Robinson, Danielle E. (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Caskey, Fergus (University of Bristol. Population Health Sciences) ;
Arden, N. K (MRC Lifecourse Epidemiology Unit) ;
Ben-Shlomo, Yoav (University of Bristol. Population Health Sciences) ;
Nybo, Mads (Odense University Hospital (Dinamarca)) ;
Rubin, Katrine H. (University of Southern Denmark. Department of Health) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit) ;
Javaid, M. K. (MRC Lifecourse Epidemiology Unit) ;
Hermann, Anne P. (Odense University Hospital (Dinamarca)) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
2021 - 10.1007/s11657-021-01001-9
Archives of Osteoporosis, Vol. 16 (september 2021)
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3.
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11 p, 810.9 KB |
The treatment gap after major osteoporotic fractures in Denmark 2005-2014 : a combined analysis including both prescription-based and hospital-administered anti-osteoporosis medications
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Skjødt, M. K. (Holbæk Hospital (Dinamarca)) ;
Ernst, M. T. (University of Southern Denmark. Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine) ;
Khalid, Sara (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Libanati, C. (UCB Pharma) ;
Cooper, Cyrus (University of Southampton) ;
Delmestri, Antonella (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Rubin, K. H. (University of Southern Denmark) ;
Javaid, M. K. (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Martínez-Laguna, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Prieto-Alhambra, Daniel (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Abrahamsen, Bo (Oxford University Hospitals. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Universitat Autònoma de Barcelona
This study demonstrates a substantial and persistent anti-osteoporosis treatment gap in men and women ≥50 years old who sustained major osteoporotic fracture(s) between 2005 and 2014 in Denmark. This was not substantially reduced by including hospital-administered anti-osteoporosis treatments. [...]
2021 - 10.1007/s00198-021-05890-x
Osteoporosis International, Vol. 32 (march 2021) , p. 1961-1971
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4.
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12 p, 944.6 KB |
Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B-5) chronic kidney disease : an open cohort multivariable and propensity score analysis from Funen, Denmark
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Ali, M. Sanni (London School of Hygiene and Tropical Medicine. Department of Non-communicable Disease Epidemiology) ;
Ernst, Martin (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ;
Robinson, Danielle E. (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Caskey, Fergus (University of Bristol. Population Health Sciences) ;
Arden, N. K (MRC Lifecourse Epidemiology Unit) ;
Ben-Shlomo, Yoav (University of Bristol. Population Health Sciences) ;
Nybo, Mads (Odense University Hospital (Dinamarca)) ;
Rubin, Katrine H. (University of Southern Denmark. Department of Health) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit) ;
Javaid, M. K. (MRC Lifecourse Epidemiology Unit) ;
Hermann, Anne P. (Odense University Hospital (Dinamarca)) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
Bisphosphonates are contraindicated in moderate-to-severe chronic kidney disease patients. However, they are used to prevent fragility fractures in patients with impaired kidney function, despite a lack of evidence on their effects on bone density in these patients. [...]
2020 - 10.1007/s11657-020-00746-z
Archives of Osteoporosis, Vol. 15 (june 2020)
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5.
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10 p, 780.0 KB |
Secular trends in the initiation of therapy in secondary fracture prevention in Europe : a multi-national cohort study including data from Denmark, Catalonia, and the United Kingdom
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Skjødt, M. K. (Odense University Hospital (Dinamarca)) ;
Khalid, Sara (Oxford University Hospitals. Nuffield Orthopaedic Centre) ;
Ernst, M. (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ;
Rubin, K. H. (Odense University Hospital (Dinamarca)) ;
Martínez-Laguna, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Delmestri, Antonella (Oxford University Hospitals. Nuffield Orthopaedic Centre) ;
Javaid, M. K. (Oxford University Hospitals. Nuffield Orthopaedic Centre) ;
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Libanati, C. (UCB Pharma) ;
Toth, E. (UCB Pharma) ;
Abrahamsen, Bo (Oxford University Hospitals. Nuffield Orthopaedic Centre) ;
Prieto-Alhambra, Daniel (Oxford University Hospitals. Nuffield Orthopaedic Centre)
This paper demonstrates a large post-fracture anti-osteoporosis treatment gap in the period 2005 to 2015. The gap was stable in Denmark at around 88-90%, increased in Catalonia from 80 to 88%, and started to increase in the UK towards the end of our study. [...]
2020 - 10.1007/s00198-020-05358-4
Osteoporosis International, Vol. 31 (march 2020) , p. 1535-1544
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15 p, 1.4 MB |
Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data : a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database
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Khalid, Sara (University of Oxford. NIHR Biomedical Research Centre) ;
Calderon-Larrañaga, Sara (Family and Community Medicine Teaching Unit of Granada. Cartuja University Health Centre. Andalusian Health Service (SAS), Granada, Spain) ;
Hawley, Samuel (University of Oxford. NIHR Biomedical Research Centre) ;
Ali, M. Sanni (London School of Hygiene and Tropical Medicine, London, United Kingdom) ;
Judge, Andrew (Bristol NIHR Biomedical Research Centre (Bristol, Regne Unit)) ;
Arden, N. K (University of Oxford. Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis) ;
van Staa, Tjeerd (Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands) ;
Cooper, Cyrus (NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom) ;
Javaid, Muhammad Kassim (University of Oxford. NIHR Biomedical Research Centre) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. We investigated two primary care records databases covering UK National Health Service (Clinical Practice Research Datalink, CPRD) and Catalan healthcare (Information System for Research in Primary Care, SIDIAP) patients during 1995-2014 and 2006-2014, respectivey. [...]
2018 - 10.2147/CLEP.S164112
Clinical Epidemiology, Vol. 10 (october 2018) , p. 1417-1431
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7.
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8 p, 2.2 MB |
Prevalence and Mortality of Individuals With X-Linked Hypophosphatemia : A United Kingdom Real-World Data Analysis
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Hawley, Samuel (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Shaw, Nick J. (Institute of Metabolism & Systems Research, University of Birmingham) ;
Delmestri, Antonella (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Pinedo-Villanueva, Rafael (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Javaid, M. Kassim (MRC Lifecourse Epidemiology Unit, University of Southampton)
X-linked hypophosphatemia (XLH) is a rare multisystemic disease with a prominent musculoskeletal phenotype. We aim here to improve understanding of the prevalence of XLH across the life course and of overall survival among people with XLH. [...]
2020 - 10.1210/clinem/dgz203
The journal of clinical endocrinology & metabolism, Vol. 105 Num. 3 (March 2020)
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8.
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8 p, 1.6 MB |
Unplanned admissions for patients with myeloma in the UK : Low frequency but high costs
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Kolovos, Spyros (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Nador, Guido (Oxford University Hospitals NHS Trust) ;
Kishore, Bhuvan (Heart of England NHS Foundation Trust) ;
Streetly, Matthew (King's College London) ;
Rabin, Neil K. (Department of Haematology, University College London Hospitals NHS Foundation Trust) ;
Chantry, Andrew D. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Yong, Kwee (UCL Cancer Institute (Londres, Regne Unit)) ;
Ashcroft, John (Department of Haematology, Mid Yorkshire NHS Trust) ;
Bowcock, Stella (King's College Hospital NHS Foundation Trust) ;
Drayson, Mark T. (Institute of Immunology and Immunotherapy, University of Birmingham) ;
Ramasamy, Karthik (Oxford University Hospitals NHS Trust) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona) ;
Cooper, Cyrus (NIHR Oxford Biomedical Research Centre) ;
Javaid, M. Kassim (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Pinedo-Villanueva, Rafael (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford)
Multiple myeloma (MM) is associated with high healthcare resource utilisation and increasing hospitalisation rates. The aim of this study was to characterise the hospital use by patients with MM in the English National Health Service (NHS). [...]
2019 - 10.1016/j.jbo.2019.100243
Journal of Bone Oncology, Vol. 17 (august 2019)
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9.
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16 p, 1.4 MB |
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
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Huang, W. (North Carolina State University. Department of Biological Sciences) ;
Massouras, A. (Ecole Polytechnique Fédérale de Lausanne. Institute of Bioengineering) ;
Inoue, Y. (Osaka University. Center for Education in Liberal Arts and Sciences) ;
Peiffer, J. (North Carolina State University. Department of Biological Sciences) ;
Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tarone, A. M. (Texas AandM University. Department of Entomology) ;
Turlapati, L. (North Carolina State University. Department of Biological Sciences) ;
Zichner, T. (European Molecular Biology Laboratory) ;
Zhu, Dianhui (Baylor College of Medicine. Human Genome Sequencing Center) ;
Lyman, R. F. (North Carolina State University. Department of Biological Sciences) ;
Magwire, M. M. (North Carolina State University. Department of Biological Sciences) ;
Blankenburg, K. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Carbone, M. A. (North Carolina State University. Department of Biological Sciences) ;
Chang, K. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Ellis, L. L. (Texas AandM University. Department of Entomology) ;
Fernandez, S. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Han, Y. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Highnam, G. (Virginia Tech. Virginia Bioinformatics Institute) ;
Hjelmen, C. E. (Texas AandM University. Department of Entomology) ;
Jack, J. R. (North Carolina State University. Department of Biological Sciences) ;
Javaid, M. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Jayaseelan, J. C (Baylor College of Medicine. Human Genome Sequencing Center) ;
Kalra, D. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Lee, S. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Lewis, Lora (Baylor College of Medicine. Human Genome Sequencing Center) ;
Munidasa, M. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Ongeri, F. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Patel, Shohba (Baylor College of Medicine. Human Genome Sequencing Center) ;
Perales, L. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Perez, Agapito (Baylor College of Medicine. Human Genome Sequencing Center) ;
Pu, L. L. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Rollmann, S. M. (North Carolina State University. Department of Biological Sciences) ;
Ruth, R. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Saada, N. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Warner, C. (Shell International Exploration and Production, Inc.) ;
Williams, A. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Wu, Y. Q. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Yamamoto, A. (North Carolina State University. Department of Biological Sciences) ;
Zhang, Yiqing (Baylor College of Medicine. Human Genome Sequencing Center) ;
Zhu, Y. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Anholt, Robert R. H (North Carolina State University. Department of Biological Sciences) ;
Korbel, Jan O. (European Molecular Biology Laboratory) ;
Mittelman, D. (Virginia Tech. Virginia Bioinformatics Institute. Department of Biological Sciences) ;
Muzny, D. M. (Baylor College of Medicine. Human Genome Sequencing Centere) ;
Gibbs, R. A. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Johnston, J. S. (Texas AandM University. Department of Entomology) ;
Stone, E. A. (North Carolina State University. Department of Biological Sciences) ;
Richards, S. (Baylor College of Medicine. Human Genome Sequencing Center) ;
Deplancke, Bart (Swiss Institute of Bioinformatics) ;
MacKay, T. F. C (North Carolina State University. Department of Biological Sciences)
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. [...]
2014 - 10.1101/gr.171546.113
Genome research, Vol. 24, issue 7 (July 2014) , p. 1193-1208
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6 p, 807.2 KB |
The Drosophila melanogaster Genetic Reference Panel
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MacKay, Trudy F. C. (Department of Genetics. North Carolina State University) ;
Richards, Stephen (Human Genome Sequencing Center. Baylor College of Medicine) ;
Stone, Eric A. (Department of Genetics. North Carolina State University) ;
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Ayroles, Julien F. (Harvard University) ;
Zhu, Dianhui (Human Genome Sequencing Center. Baylor College of Medicine) ;
Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Han, Yi (Human Genome Sequencing Center. Baylor College of Medicine) ;
Magwire, Michael M. (Department of Genetics. North Carolina State University) ;
Cridland, Julie M. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ;
Richardson, Mark F. (Faculty of Life Sciences. University of Manchester) ;
Anholt, Robert R. H. (Department of Biology. North Carolina State University) ;
Barrón Aduriz, Maite Garazi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bess, Crystal (Human Genome Sequencing Center. Baylor College of Medicine) ;
Blankenburg, Kerstin Petra (Human Genome Sequencing Center. Baylor College of Medicine) ;
Carbone, Mary Anna (Department of Genetics. North Carolina State University) ;
Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Chaboub, Lesley (Human Genome Sequencing Center. Baylor College of Medicine) ;
Duncan, Laura (Department of Genetics. North Carolina State University) ;
Harris, Zeke (Department of Genetics. North Carolina State University) ;
Javaid, Mehwish (Human Genome Sequencing Center. Baylor College of Medicine) ;
Jayaseelan, Joy Christina (Human Genome Sequencing Center. Baylor College of Medicine) ;
Jhangiani, Shalini N. (Human Genome Sequencing Center. Baylor College of Medicine) ;
Jordan, Katherine W. (Department of Genetics. North Carolina State University) ;
Lara, Fremiet (Human Genome Sequencing Center. Baylor College of Medicine) ;
Lawrence, Faye (Department of Genetics. North Carolina State University) ;
Lee, Sandra L. (Human Genome Sequencing Center. Baylor College of Medicine) ;
Librado, Pablo (Universitat de Barcelona. Departament de Genètica) ;
Linheiro, Raquel S. (Faculty of Life Sciences. University of Manchester) ;
Lyman, Richard F. (Department of Genetics. North Carolina State University) ;
MacKey, Aaron J. (Center for Public Health Genomics. University of Virginia) ;
Munidasa, Mala (Human Genome Sequencing Center. Baylor College of Medicine) ;
Muzny, Donna Marie (Human Genome Sequencing Center. Baylor College of Medicine) ;
Nazareth, Lynne (Human Genome Sequencing Center. Baylor College of Medicine) ;
Newsham, Irene (Human Genome Sequencing Center. Baylor College of Medicine) ;
Perales, Lora (Human Genome Sequencing Center. Baylor College of Medicine) ;
Pu, Ling-Ling (Human Genome Sequencing Center. Baylor College of Medicine) ;
Qu, Carson (Human Genome Sequencing Center. Baylor College of Medicine) ;
Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Reid, Jeffrey G. (Human Genome Sequencing Center. Baylor College of Medicine) ;
Rollmann, Stephanie M. (Department of Biological Sciences. University of Cincinnati) ;
Rozas, Julio (Universitat de Barcelona. Departament de Genètica) ;
Saada, Nehad (Human Genome Sequencing Center. Baylor College of Medicine) ;
Turlapati, Lavanya (Department of Genetics. North Carolina State University) ;
Worley, Kim C. (Human Genome Sequencing Center. Baylor College of Medicine) ;
Wu, Yuan-Qing (Human Genome Sequencing Center. Baylor College of Medicine) ;
Yamamoto, Akihiko (Department of Genetics. North Carolina State University) ;
Zhu, Yiming (Human Genome Sequencing Center. Baylor College of Medicine) ;
Bergman, Casey M. (Faculty of Life Sciences. University of Manchester) ;
Thornton, Kevin R. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ;
Mittelman, David (Virginia Bioinformatics Institute. Department of Biological Sciences. Virginia Tech) ;
Gibbs, Richard A. (Human Genome Sequencing Center. Baylor College of Medicine)
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. [...]
2012 - 10.1038/nature10811
Nature, Vol. 482, issue 7384 (Feb. 2012) , p. 173-178
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