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14 p, 3.9 MB Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice / Blázquez-Bermejo, Cora (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Molina-Granada, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vila-Julià, Ferran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jiménez-Heis, Daniel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zhou, Xiaoshan (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Torres-Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Karlsson, Anna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Martí, Ramon A. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Cámara, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Thymidine kinase 2 (TK2) catalyses the phosphorylation of deoxythymidine (dThd) and deoxycytidine (dCtd) within mitochondria. TK2 deficiency leads to mtDNA depletion or accumulation of multiple deletions. [...]
2019 - 10.1016/j.ebiom.2019.07.042
EBioMedicine, Vol. 46 (july 2019) , p. 342-355  
Detailed record - Creative Commons

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