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1.
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3 p, 207.7 KB |
In reply : Sex-specific outcomes in COVID-19: missing pieces of the puzzle
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Wolff, Georg (Heinrich-Heine-University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (University of Bergen) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Düsseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Düsseldorf) ;
Binneboessel, Stephan (Heinrich-Heine-University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Düsseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sivri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Flamm, Maria (Paracelsus Medical University) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Jung, Christian (Heinrich-Heine-University Düsseldorf) ;
Universitat Autònoma de Barcelona
2023 -  10.1007/s12630-023-02470-x
Canadian Journal of Anaesthesia, may 2023, p. 1-3
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2.
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9 p, 1.0 MB |
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19 : results from an international observational study of 2860 patients
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Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (Haukeland University Hospital) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Binnebössel, Stephan (Heinrich-Heine-University Duesseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sigal, Sivri (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Wollborn, Jakob (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Arche Banzo, Maria José (Hospital Clínico Universitario Lozano Blesa) ;
Fuest, Kristina (Technical University of Munich) ;
Marsh, Brian (Mater Misericordiae University Hospital) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Leaver, Susannah (St George'S University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Universitat Autònoma de Barcelona
Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have been mostly affected during the initial surge in 2020. [...]
2021 - 10.1186/s13613-021-00911-8
Annals of Intensive Care, Vol. 11 (august 2021)
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3.
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12 p, 1.6 MB |
Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
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Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hadassah University Medical Center) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Czuczwar, Miroslaw (Medical University of Lublin) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Leaver, Susannah (St George's University Hospital NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Flaatten, Hans (University of Bergen) ;
Universitat Autònoma de Barcelona
The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted with COVID-19 disease from March to December 2020 to 159 ICUs in 14 European countries. [...]
2021 - 10.1186/s13054-021-03739-7
Critical Care, Vol. 25 (september 2021)
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4.
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10 p, 3.2 MB |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
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Bruno, Raphael Romano (Heinrich Heine University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University Salzburg) ;
Wolff, Georg (Heinrich Heine University Düsseldorf) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kindgen-Milles, Detlef (Heinrich Heine University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich Heine University Düsseldorf) ;
Kelm, Malte (Medical Faculty of the Heinrich-Heine University) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Topeli, Arzu (Hacettepe University Faculty of Medicine) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Kondili, Eumorfia (University Hospital of Heraklion) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Nova Medical School) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (Utrecht University) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Jung, Christian (Heinrich Heine University Düsseldorf) ;
Universitat Autònoma de Barcelona
Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. [...]
2022 - 10.1002/ehf2.13854
ESC Heart Failure, Vol. 9 (march 2022) , p. 1756-1765
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5.
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9 p, 295.2 KB |
Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study
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Wolff, Georg (Heinrich-Heine-University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (University of Bergen) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Düsseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Düsseldorf) ;
Binneboessel, Stephan (Heinrich-Heine-University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Düsseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sivri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Flamm, Maria (Paracelsus Medical University) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Nova Médical School) ;
Boumendil, Ariane (Sorbonne Universités) ;
De Lange, Dylan W. (University Medical Center) ;
Guidet, Bertrand (Sorbonne Universités) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Jung, Christian (Heinrich-Heine-University) ;
Universitat Autònoma de Barcelona
Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort. [...]
2022 - 10.1007/s12630-022-02304-2
Canadian Journal of Anaesthesia, august 2022, p. 1-9
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6.
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9 p, 1.2 MB |
A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
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Wernly, Bernhard (General Hospital Oberndorf) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Fjølner, Jesper (Viborg Regional Hospital) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Sigal, Sviri (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Rezar, Richard (Paracelsus Medical University of Salzburg) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Universidade da Beira Interior) ;
Wernly, Sarah (General Hospital Oberndorf) ;
Leaver, Susannah (St. George's University Hospital NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine (França)) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine (França)) ;
Perings, Stefan (Heinrich-Heine-University Duesseldorf) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Universitat Autònoma de Barcelona
In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. [...]
2022 - 10.1038/s41598-022-21580-y
Scientific reports, Vol. 12 (october 2022)
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7.
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12 p, 1012.4 KB |
Noninvasive ventilation in COVID-19 patients aged ≥ 70 years-a prospective multicentre cohort study
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Polok, Kamil (Jagiellonian University Medical College) ;
Fronczek, Jakub (Jagiellonian University Medical College) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Flaatten, Hans (University of Bergen) ;
Guidet, Bertrand (Hôpitaux de Paris) ;
De Lange, Dylan W. (University Utrecht) ;
Fjølner, Jesper (Viborg Regional Hospital) ;
Leaver, Susannah (St George's Hospital) ;
Beil, Michael (Hadassah Medical Center) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University of Salzburg) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (Bern University Hospital) ;
Studzińska, Dorota (Jagiellonian University Medical College) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Universidade da Beira Interior) ;
Cecconi, Maurizio (Humanitas University) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Universitat Autònoma de Barcelona
Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. [...]
2022 - 10.1186/s13054-022-04082-1
Critical Care, Vol. 26 (july 2022)
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9 p, 437.1 KB |
Consent is a confounding factor in a prospective observational study of critically ill elderly patients
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Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Guidet, Bertrand (Sorbonne Université) ;
Jung, Christian (University Hospital of Düsseldorf (Alemanya)) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
Leaver, Susannah (Research Lead Critical Care Directorate St George's Hospital) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Andersen, Finn H (Ålesund Hospital) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Walther, Sten (Linkoping University Hospital) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Schefold, Joerg C. (University of Bern) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Joannidis, Michael (Medical University Innsbruck) ;
Elhadi, Muhammed (University of Tripili) ;
Nalapko, Yuriy (European Wellness International) ;
Fjølner, Jesper (Viborg Regional Hospital) ;
De Lange, Dylan W (University Utrecht) ;
Universitat Autònoma de Barcelona
During analysis of a prospective multinational observation study of critically ill patients ≥80 years of age, the VIP2 study, we also studied the effects of differences in country consent for study inclusion. [...]
2022 - 10.1371/journal.pone.0276386
PloS one, Vol. 17 (october 2022)
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9.
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8 p, 835.5 KB |
Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury
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Pickkers, Peter (Nijmegen) ;
Angus, Derek C (University of Pittsburgh School of Medicine) ;
Arend, Jacques (AM-Pharma BV) ;
Bellomo, Rinaldo (Austin Hospital) ;
van den Berg, Erik (AM-Pharma BV) ;
Bernholz, Juliane (AM-Pharma BV) ;
Bestle, Morten (Copenhagen) ;
Broglio, Kristine (Berry Consultants) ;
Carlsen, Jan (AM-Pharma BV) ;
Doig, Christopher J ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament d'Infermeria) ;
Joannidis, Michael (Medical University Innsbruck) ;
Francois, Bruno (University of Limoges) ;
Doi, Kent (The University of Tokyo Hospital) ;
Kellum, John A ;
Laterre, Pierre-François (Brussels) ;
Liu, Kathleen (University of California San Fransisco) ;
Mehta, Ravindra L (University of California) ;
Murray, Patrick T (Dublin) ;
Ostermann, Marlies (King's College London) ;
Pettilä, Ville (Helsinki) ;
Richards, Sharon (PHASTAR) ;
Young, Paul (Wellington) ;
Zarbock, Alexander (Universität Münster) ;
Kjølbye, Anne Louise (AM-Pharma BV)
Sepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety or tolerability concerns in a phase 2 trial. [...]
2023 - 10.1136/bmjopen-2022-065613
BMJ open, Vol. 13 (april 2023)
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14 p, 1.9 MB |
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 - 10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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