Results overview: Found 4 records in 0.02 seconds.
Articles, 4 records found
Articles 4 records found  
1.
19 p, 13.4 MB Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis : evidence for metformin-based "starvation" strategies in BRCA1 carriers / Cuyàs, Elisabet (Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain) ; Fernández-Arroyo, Salvador (Hospital Universitari Sant Joan de Reus) ; Alarcón, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Joven, Jorge (Hospital Universitari Sant Joan de Reus) ; Menendez, Javier A. (Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain)
We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. [...]
2016 - 10.18632/oncotarget.9732
Oncotarget, Vol. 7 (may 2016) , p. 52974-52992  
2.
13 p, 3.9 MB Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome / Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Folguera-Blasco, Núria (Centre de Recerca Matemàtica) ; Cuyàs Navarro, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971  
3.
11 p, 2.4 MB Oncometabolic nuclear reprogramming of cancer stemness / Menendez, Javier A. (Institut Català d'Oncologia) ; Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; García, María G. (Instituto Universitario de Oncología del Principado de Asturias) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Fraga, Mario F. (Instituto Universitario de Oncología del Principado de Asturias) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. [...]
2016 - 10.1016/j.stemcr.2015.12.012
Stem cell reports, Vol. 6, issue 3 (March 2016) , p. 273-283  
4.
9 p, 567.0 KB Risk of hyperkalemia in patients with moderate chronic kidney disease initiating angiotensin converting enzyme inhibitors or angiotensin receptor blockers : a randomized study / Espinel Garuz, Eugenia (Hospital Universitari Vall d'Hebron) ; Joven Maried, Jorge (Universitat Rovira i Virgili) ; Gil, Iván (Hospital Universitari Vall d'Hebron) ; Suñé, Pilar (Hospital Universitari Vall d'Hebron) ; Renedo, Berta (Hospital Universitari Vall d'Hebron) ; Fort Ros, Joan (Hospital Universitari Vall d'Hebron) ; Serón Micas, Daniel (Hospital Universitari Vall d'Hebron)
Background: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are renoprotective but both may increase serum potassium concentrations in patients with chronic kidney disease (CKD). [...]
2013 - 10.1186/1756-0500-6-306
BMC public health, Vol. 6, N. 306 (August 2013) , p. 1-9  

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