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16 p, 4.7 MB The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo / Kafa, Houmam (King's College London. Institute of Pharmaceutical Science) ; Wang, Julie Tzu-Wen (King's College London. Institute of Pharmaceutical Science) ; Rubio, Noelia (King's College London. Institute of Pharmaceutical Science) ; Venner, Kerrie (University College London. Institute of Neurology) ; Anderson, Glenn (Great Ormond Street Hospital for Children. Histopathology Department) ; Pach, Elzbieta (Institut Catala de Nanociència i Nanotecnologia) ; Ballesteros Pérez, Belén (Institut Català de Nanociència i Nanotecnologia) ; Preston, Jane E. (King's College London. Institute of Pharmaceutical Science) ; Abbott, N. Joan (King's College London. Institute of Pharmaceutical Science) ; Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Carbon nanotubes (CNTs) are a novel nanocarriers with interesting physical and chemical properties. Here we investigate the ability of amino-functionalized multi-walled carbon nanotubes (MWNTs-NH₃+) to cross the Blood-Brain Barrier (BBB) in vitro using a co-culture BBB model comprising primary porcine brain endothelial cells (PBEC) and primary rat astrocytes, and in vivo following a systemic administration of radiolabelled f -MWNTs. [...]
2015 - 10.1016/j.biomaterials.2015.02.083
Biomaterials, Vol. 53 (June 2015) , p. 437-452  

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