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24 p, 1.8 MB Simulation and prediction of protein production in fed-batch E. coli cultures : an engineering approach / Calleja Martínez, Daniel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Kavanagh, John (The University of Sydney. School of Chemical and Biomolecular Engineering) ; Mas i Rocabayera, Carles de (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; López Santín, Josep (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
An overall model describing the dynamic behavior of fed-batch E. coli processes for protein production has been built, calibrated and validated. Using a macroscopic approach, the model consists of three interconnected blocks allowing simulation of biomass, inducer and protein concentration profiles with time. [...]
2016 - 10.1002/bit.25842
Biotechnology and bioengineering, Vol. 113, No. 4 (April 2016) , p. 772-782  
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