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8 p, 835.5 KB |
Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury
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Pickkers, Peter (Nijmegen) ;
Angus, Derek C (University of Pittsburgh School of Medicine) ;
Arend, Jacques (AM-Pharma BV) ;
Bellomo, Rinaldo (Austin Hospital) ;
van den Berg, Erik (AM-Pharma BV) ;
Bernholz, Juliane (AM-Pharma BV) ;
Bestle, Morten (Copenhagen) ;
Broglio, Kristine (Berry Consultants) ;
Carlsen, Jan (AM-Pharma BV) ;
Doig, Christopher J ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament d'Infermeria) ;
Joannidis, Michael (Medical University Innsbruck) ;
Francois, Bruno (University of Limoges) ;
Doi, Kent (The University of Tokyo Hospital) ;
Kellum, John A ;
Laterre, Pierre-François (Brussels) ;
Liu, Kathleen (University of California San Fransisco) ;
Mehta, Ravindra L (University of California) ;
Murray, Patrick T (Dublin) ;
Ostermann, Marlies (King's College London) ;
Pettilä, Ville (Helsinki) ;
Richards, Sharon (PHASTAR) ;
Young, Paul (Wellington) ;
Zarbock, Alexander (Universität Münster) ;
Kjølbye, Anne Louise (AM-Pharma BV)
Sepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety or tolerability concerns in a phase 2 trial. [...]
2023 -  10.1136/bmjopen-2022-065613
BMJ open, Vol. 13 (april 2023)
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11 p, 983.1 KB |
Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury
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Prowle, John R. (Queen Mary University of London) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bagshaw, Sean M. (University of Alberta) ;
Forni, Lui G. (University of Surrey and Royal Surrey County Hospital NHS Foundation Trust, Guildford) ;
Heung, Michael (University of Michigan) ;
Hoste, Eric (Ghent Universit) ;
Marlies, Ostermann (King's College London) ;
Koyner, Jay L. (University of Chicago) ;
Chawla, Lakhmir S (Veterans Affairs Medical Center) ;
Kampf, J. Patrick (Astute Medical (Estats Units d'Amèrica)) ;
Kwan, Thomas (University of Pittsburgh) ;
McPherson, Paul (Astute Medica (Estats Units d'Amèrica)) ;
Kellum, John A. (University of Pittsburg)
Retrospective observational study. Data derived from two multinational ICU studies (Ruby and Sapphire). Critically ill patients with early stage 2-3 AKI. None. We analyzed three consecutive uCCL14 measurements at 12-hour intervals after diagnosis of stage 2-3 AKI by Kidney Disease Improving Global Outcomes criteria. [...]
2023 - 10.1097/CCE.0000000000000870
Critical Care Explorations, Vol. 5 (march 2023)
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8 p, 961.6 KB |
External validation of urinary C-C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury
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Bagshaw, Sean M. (University of Alberta) ;
Al-Khafaji, Ali (University of Pittsburgh) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Davison, Danielle (George Washington University) ;
Haase, Michael (Otto Von-Guericke-University Magdeburg) ;
Lissauer, Matthew (Rutgers-Robert Wood Johnson Medical School) ;
Zacharowski, Kai (Goethe University) ;
Chawla, Lakhmir S. (Veterans Affairs Medical Center) ;
Kwan, Thomas (Astute Medical (Estats Units d'Amèrica)) ;
Kampf, J. Patrick (Astute Medical (Estats Units d'Amèrica)) ;
McPherson, Paul (Astute Medical (Estats Units d'Amèrica)) ;
Kellum, John A. (University of Pittsburgh) ;
Universitat Autònoma de Barcelona
Persistent acute kidney injury (AKI) portends worse clinical outcomes and remains a therapeutic challenge for clinicians. A recent study found that urinary C-C motif chemokine ligand 14 (CCL14) can predict the development of persistent AKI. [...]
2021 - 10.1186/s13054-021-03618-1
Critical Care, Vol. 25 (may 2021)
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9 p, 1.0 MB |
Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection
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Kellum, John A. (Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, Pittsburgh, PA) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gunnerson, Kyle J. (Departments of Emergency Medicine/Critical Care, Anesthesiology, Internal Medicine, Michigan Center for Integrative Research in Critical Care (MCIRCC), University of Michigan, Ann Arbor, MI) ;
Honore, Patrick M. (Department of Intensive Care Medicine, Brugmann University Hospital, Brussels, Belgium) ;
Kampf, J. Patrick (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
Kwan, Thomas (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
McPherson, Paul (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
Nguyen, H. Bryant (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Loma Linda University, Loma Linda, CA) ;
Rimmelé, Thomas (Department of Anesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France) ;
Shapiro, Nathan I. (Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA) ;
Shi, Jing (Walker BioSciences, Carlsbad, CA) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Chawla, Lakhmir S. (Department of Medicine, Veterans Affairs Medical Center, San Diego, CA) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. Retrospective, international, Sapphire study. Academic Medical Center. Adults admitted to the ICU without evidence of acute kidney injury at time of enrollment. [...]
2021 - 10.1097/CCM.0000000000004845
Critical Care Medicine, Vol. 49 (january 2021) , p. e360-e368
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10 p, 642.7 KB |
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis
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Honore, Patrick M. (Vrije Universiteit Amsterdam) ;
Nguyen, H. Bryant (Department of Medicine, Pulmonary and Critical Care Medicine and Department of Emergency Medicine, Loma Linda University, Loma Linda, CA) ;
Gong, Michelle (Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY) ;
Chawla, Lakhmir S. (Department of Medicine, Division of Intensive Care Medicine and Division of Nephrology, Veterans Affairs Medical Center, and Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington, DC) ;
Bagshaw, Sean M. (Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Shi, Jing (Walker Biosciences, Carlsbad, CA) ;
Joannes-Boyau, Olivier (Department of Anesthesiology and Critical Care Medicine 2, Hospital Haut Leveque, University of Bordeaux 2, Bordeaux, France) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Kellum, John A. ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. [...]
2016 - 10.1097/CCM.0000000000001827
Critical Care Medicine, Vol. 44 (september 2016) , p. 1851-1860
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