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15 p, 1007.8 KB An original phylogenetic approach identified mitochondrial haplogrou,p T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers / Blein, Sophie (Université Lyon 1) ; Bardel, Claire (Université Claude Bernard Lyon 1) ; Danjean, Vincent (INRIA Rhône-Alpes (França)) ; McGuffog, Lesley (University of Cambridge) ; Healey, Sue (QIMR Berghofer (Australia)) ; Barrowdale, Daniel (University of Cambridge) ; Lee, Andrew (University of Cambridge) ; Dennis, Joe (University of Cambridge) ; Kuchenbaecker, Karoline B. (University of Cambridge) ; Soucy, Penny (Laval University (Canadà)) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy K. (Columbia University College of Physicians and Surgeons) ; Goldgar, David E. (University of Utah School of Medicine) ; Buys, Saundra (University of Utah School of Medicine) ; Janavicius, Ramunas (State Research Institute (Lituania)) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tung, Nadine (Beth Israel Deaconess Medical Center (Estats Units d'Amèrica)) ; Dorfling, Cecilia M. (University of Pretoria) ; van Rensburg, Elizabeth J. (University of Pretoria (Estats Units d'Amèrica)) ; Neuhausen, Susan L. (Beckman Research Institute (Estats Units d'Amèrica)) ; Ding, Yuan Chun (Beckman Research Institute (Estats Units d'Amèrica)) ; Gerdes, Anne-Marie (Copenhagen University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital) ; Nielsen, Finn C. (Copenhagen University Hospital) ; Hansen, Thomas V. O. (Copenhagen University Hospital) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Conejero, Raquel Andrés (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Segota, Ena (Clinical Cancer Genetics Community Research Network(Estats Units d'Amèrica)) ; Weitzel, Jeffrey N. (Division of Clinical Cancer Genetics(Estats Units d'Amèrica)) ; Thelander, Margo (Walnut Creek (Estats Units d'Amèrica)) ; Peterlongo, Paolo (Istituto FIRC di Oncologia Molecolare) ; Radice, Paolo (Istituto di Ricovero e Cura a Carattere Scientifico) ; Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory (Itàlia)) ; Dolcetti, Riccardo (Centro di Riferimento Oncologico (Itàlia)) ; Bonanni, Bernardo (Istituto Europeo di Oncologia (Itàlia)) ; Peissel, Bernard (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Zaffaroni, Daniela (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Scuvera, Giulietta (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Manoukian, Siranoush (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Varesco, Liliana (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Capone, Gabriele L. (University of Florence, Florence) ; Papi, Laura (University of Florence, Florence) ; Ottini, Laura (Sapienza University) ; Yannoukakos, Drakoulis (Aristotle University of Thessaloniki School of Medicine) ; Konstantopoulou, Irene (Aghia Paraskevi Attikis) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Hamann, Ute (Deutsches Krebsforschungszentrum) ; Donaldson, Alan (St Michael's Hospital) ; Brady, Angela (Kennedy-Galton Centre) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Foo, Claire (Liverpool Women's NHS Foundation Trust) ; Evans, D. Gareth (Central Manchester University Hospitals NHS Foundation Trust) ; Frost, Debra (University of Cambridge, Worts Causeway) ; Eccles, Diana (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Douglas, Fiona (Institute of Human Genetics, Northern Genetic Service (Regne Unit)) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Adlard, Julian (Yorkshire Regional Genetics Service) ; Barwell, Julian (Leicestershire Clinical Genetics Service) ; Walker, Lisa (Churchill Hospital) ; Izatt, Louise (St Thomas' NHS Foundation Trust) ; Side, Lucy E. (Great Ormond Street Hospital for Children (Londres)) ; Kennedy, M. John (St. James's Hospital ( Dublín, Irlanda)) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Rogers, Mark T. (University Hospital of Wales) ; Porteous, Mary E. (Western General Hospital) ; Morrison, Patrick J. (Belfast City Hospital, Lisburn Road) ; Platte, Radka (University of Cambridge) ; Eeles, Ros (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust) ; Davidson, Rosemarie (Yorkhill Hospitals) ; Hodgson, Shirley (St George's University of London) ; Cole, Trevor (Birmingham Women's Hospital) ; Godwin, Andrew K. (DUniversity of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20057 USA) ; Claes, Kathleen (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; Meindl, Alfons (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Gehrig, Andrea (Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany) ; Wappenschmidt, Barbara (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ; Plendl, Hansjoerg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Kast, Karin (Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany) ; Rhiem, Kerstin (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Ditsch, Nina (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Varon-Mateeva, Raymonda (Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany) ; Schmutzler, Rita K. (German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany) ; Preisler-Adams, Sabine (University Hospital of Münster (Alemanya)) ; Markov, Nadja Bogdanova (University Hospital of Münster (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; De Pauw, Antoine (Institut Curie. Department of Tumour Biology) ; Lefol, Cédrick (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lasset, Christine (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Leroux, Dominique (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Rouleau, Etienne (Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210 Saint-Cloud, France) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Dreyfus, Hélène (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Barjhoux, Laure (Centre National de la Recherche Scientifique (França)) ; Golmard, Lisa (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Uhrhammer, Nancy (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Bonadona, Valérie (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Sornin, Valérie (Centre National de la Recherche Scientifique (França)) ; Bignon, Yves-Jean (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Carter, Jonathan (Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW 2050 Australia) ; Van Le, Linda (Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC 27599-7572 USA) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263-0001 USA) ; DiSilvestro, Paul A. (Women & Infants Hospital, 1 Blackstone Place, Providence, RI 02905 USA) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 Helsinki, Finland) ; Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290 Helsinki, Finland) ; Jager, Agnes (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands) ; van den Ouweland, Ans M. W. (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands) ; Kets, Carolien M. (Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands) ; Aalfs, Cora M. (Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands) ; van Leeuwen, Flora E. (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Meijers-Heijboer, Hanne E. J. (Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands) ; Oosterwijk, Jan C. (Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands) ; van Roozendaal, Kees E. P. (Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands) ; Rookus, Matti A. (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Devilee, Peter (Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q Leiden, the Netherlands) ; van der Luijt, Rob B. (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122 Budapest, Hungary) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Del Valle, Jesús (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Sukiennicki, Grzegorz (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Maugard, Christine (Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France) ; Amadori, Alberto (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Teixeira, Manuel R. (Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal) ; Spurdle, Amanda B. (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC J2W 1S6 Canada) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Lindor, Noralane M. (Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259 USA) ; Pankratz, Vernon S. (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Szabo, Csilla I (National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD 20892-2152 USA) ; Lincoln, Anne (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Jacobs, Lauren (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ; Robson, Mark (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Berger, Andreas (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Fink-Retter, Anneliese (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Kaulich, Daphne Geschwantler (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Tea, Muy-Kheng (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Mai, Phuong L. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Rennert, Gad (Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362 Haifa, Israel) ; Imyanitov, Evgeny N. (NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758 St Petersburg Russia) ; Mulligan, Anna Marie (Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8 Canada) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8 Canada) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Toland, Amanda Ewart (The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH 43210 USA) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Caligo, Maria A. (Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126 Pisa, Italy) ; Friedman, Eitan (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Zidan, Jamal (Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100 Safed, Israel) ; Laitman, Yael (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Lindblom, Annika (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Melin, Beatrice (Oncology, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Loman, Niklas (Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85 Lund, Sweden) ; Rosenquist, Richard (Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden) ; Olopade, Olufunmilayo I (Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 USA) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California, San Francisco, CA USA) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA 90089-9175 USA) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Rebbeck, Timothy R. (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Arun, Banu K. (Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX 77230-1439 USA) ; Mitchell, Gillian (Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010 VIC Australia) ; Karlan, Beth Y (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Orsulic, Sandra (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Thomas, Gilles (Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, Cedex 08 France) ; Simard, Jacques (Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ Canada) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Easton, Douglas F. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Antoniou, Antonis C. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Mazoyer, Sylvie (Université Lyon 1, 69100 Villeurbanne, France) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA) ; Sinilnikova, Olga M. (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373 Lyon, Cedex 08 France) ; Cox, David G. (Université Lyon 1, 69100 Villeurbanne, France) ; Universitat Autònoma de Barcelona
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. [...]
2015 - 10.1186/s13058-015-0567-2
Breast cancer research, Vol. 17 (april 2015)  

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