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Articles, 7 records found
Articles 7 records found  
1.
12 p, 312.7 KB Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease : An international overview / Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ; Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ; Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Arisi, Ivan (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ; Amar, Elodie Bouaziz (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ; Beaume, Anne (CHU Poitiers) ; Bedel, Aurelie (CHU Bordeaux) ; Bellomo, Giovanni (University of Perugia) ; Bigot-Corbel, Edith (CHU de Nantes) ; Bjerke, Maria (University of Antwerp) ; Blanc-Quintin, Marie-Céline (APHP Centre-Université de Paris, Cochin Hospital) ; Boada, Mercè (Instituto de Salud Carlos III) ; Bousiges, Olivier (Hôpitaux Universitaires de Strasbourg) ; Chapman, Miles D (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ; DeMarco, Mari L. (University of British Columbia) ; D'Onofrio, Mara (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ; Dumurgier, Julien (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ; Dufour-Rainfray, Diane (CHU Tours) ; Engelborghs, Sebastiaan (Center for Neurosciences and Department of Neurology) ; Esselmann, Hermann (University Medical Center Goettingen (UMG) ; Fogli, Anne (CHU Clermont-Ferrand) ; Gabelle, Audrey (INSERM) ; Galloni, Elisabetta (Dipartimento di Neuroscienze Divisione di Neurologia) ; Gondolf, Clémentine (CHU Cote de Nacre Caen) ; Grandhomme, Frédérique (CHU Cote de Nacre Caen) ; Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ; Hart, Melanie (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ; Ikeuchi, Takeshi (Niigata University) ; Jeromin, Andreas (Cohen Veterans Bioscience) ; Kasuga, Kensaku (Niigata University) ; Keshavan, Ashvini (UCL Institute of Neurology (Regne Unit)) ; Khalil, Michael (Medical University of Graz) ; Körtvelyessy, Peter (German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité-Universitäts medizin Berlin) ; Kulczynska-Przybik, Agnieszka (Medical University of Bialystok) ; Laplanche, Jean-Louis (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ; Lewczuk, Piotr (Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg) ; Li, Qiao-Xin (Florey Institute and The University of Melbourne) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Malaplate, Catherine (Biologie Moléculaire et Nutrition/ Université de Lorraine) ; Marquié, Marta (Instituto de Salud Carlos III) ; Masters, Colin L. (Florey Institute and The University of Melbourne) ; Mroczko, Barbara (Medical University of Bialystok) ; Nogueira, Léonor (CHU PURPAN) ; Orellana, Adelina (Instituto de Salud Carlos III) ; Otto, Markus (University of Ulm) ; Oudart, Jean-Baptiste (Université de Reims Champagne-Ardenne) ; Paquet, Claire (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ; Paoletti, Federico Paolini (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Perret-Liaudet, Armand (Lyon University Hospital) ; Peoc'h, Katell (Université de Paris GHU APHP Nord Beaujon Hospital) ; Poesen, Koen (Leuven Brain Institute) ; Puig-Pijoan, Albert (Institut Hospital del Mar d'Investigacions Mèdiques) ; Quadrio, Isabelle (Lyon University Hospital) ; Quillard-Muraine, Muriel (Normandie Univ) ; Rucheton, Benoit (AP-HP Sorbonne University) ; Schraen, Susanna (Université de Lille) ; Schott, Jonathan M. (UCL Institute of Neurology (Regne Unit)) ; Shaw, Leslie M. (University of Pennsylvania) ; Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Tumani, Hayrettin (University of Ulm) ; Udeh-Momoh, Chinedu T (Imperial College London) ; Vaudran, Lucie (Univ. Lille) ; Verbeek, Marcel M (Radboud University Medical Center) ; Verde, Federico ("Dino Ferrari" Center, Università degli Studi di Milano) ; Vermunt, Lisa (Vrije Universiteit Amsterdam) ; Vogelgsang, Jonathan (Harvard Medical School) ; Wiltfang, Jens (University of Aveiro) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Lehmann, Sylvain (Université de Montpellier) ; Universitat Autònoma de Barcelona
The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. [...]
2021 - 10.1002/alz.12545
Alzheimer's & Dementia, Vol. 18 (december 2021) , p. 1868-1879  
2.
13 p, 1.9 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis / Hegen, Harald (Medical University of Innsbruck) ; Walde, Janette (University of Innsbruck) ; Berek, Klaus (University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center (Israel)) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Clínica Mayo) ; Teunissen, Charlotte E (Vrije Universiteit) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Clínica Mayo) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian ; Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181  
3.
14 p, 1.1 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement / Hegen, Harald (Medical University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Mayo Clinic (Rochester)) ; Teunissen, Charlotte E (Amsterdam UMC) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Mayo Clinic) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian (Medical University of Innsbruck) ; Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195  
4.
27 p, 1.5 MB Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease : A prospective multicohort study of the ABIRISK consortium / Hässler, Signe (Hôpital Pitié-Salpêtrière) ; Bachelet, Delphine (Hôpital Bichat) ; Duhaze, Julianne (CHU Ste-Justine Research Center) ; Szely, Natacha (Paris-Sud University) ; Gleizes, Aude (Le Kremlin-Bicêtre Hospital) ; Hacein-Bey Abina, Salima (Paris-Descartes-Sorbonne-Cite University) ; Aktas, Orhan (University of Düsseldorf) ; Auer, Michael (Innsbruck Medical University) ; Avouac, Jerôme (Cochin Hospital) ; Birchler, Mary (GlaxoSmithKline (Estats Units d'Amèrica)) ; Bouhnik, Yoram (GETAID (França)) ; Brocq, Olivier (Princess Grace Hospital) ; Buck-Martin, Dorothea (Technische Universität München) ; Cadiot, Guillaume (University Hospital of Reims) ; Carbonnel, Franck (Hôpital Kremlin-Bicêtre) ; Chowers, Yehuda (Rambam Health Care Campus) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Derfuss, Tobias (University Hospital Basel (Basilea, Suïssa)) ; Sikkema, Dan (University of Amsterdam) ; Donnellan, Naoimh (Ipsen Biopharm (Regne Unit)) ; Doukani, Abiba (Sorbonne Université) ; Guger, Michael (Kepler University Hospital) ; Hartung, Hans-Peter (University of Düsseldorf) ; Kubala Havrdova, Eva (Charles University and General University Hospital, Prague, Czech Republic) ; Hemmer, Bernhard (Munich Cluster for Systems Neurology) ; Huizinga, Tom (Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands) ; Ingenhoven, Kathleen (University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany) ; Hyldgaard-Jensen, Poul Erik (Copenhagen University Hospital Rigshospitalet) ; Jury, Elizabeth C. (University College London) ; Khalil, Michael (Medical University of Graz) ; Kieseier, Bernd (University of Düsseldorf) ; Lindberg, Raija (University Hospital Basel (Basilea, Suïssa)) ; Loercher, Amy (GlaxoSmithKline (Estats Units d'Amèrica)) ; Maggi, Enrico (Bambino Gesù Children's Hospital) ; Manson, Jessica (University College London Hospital) ; Mauri, Claudia (University College London) ; Mohand Oumoussa, Badreddine (Sorbonne Université) ; Montalban, Xavier (St. Michael's Hospital) ; Nachury, Maria (University Hospital of Lille (França)) ; Nytrova, Petra (Charles University. Faculty of Medicine in Hradec Králové) ; Richez, Christophe (Bordeaux University) ; Ryner, Malin (Karolinska Institutet (Estocolm, Suècia)) ; Sellebjerg, Finn (Copenhagen University Hospital Rigshospitalet) ; Sievers, Claudia (University Hospital Basel (Basilea, Suïssa)) ; Sikkema, Dan (Quanterix Corporation (Estats Units d'Amèrica)) ; Soubrier, Martin (University Hospital of Clermont Ferrand) ; Tourdot, Sophie (Paris-Sud University) ; Trang, Caroline (CHU de Nantes) ; Vultaggio, Alessandra (Università di Firenze) ; Warnke, Clemens (University Hospital Köln) ; Spindeldreher, Sebastian (Integrated Biologix GmbH (Suïssa)) ; Dönnes, Pierre (SciCross AB (Suècia)) ; Hickling, Timothy P. (Pfizer (Estats Units d'Amèrica)) ; Hincelin Mery, Agnès (Sanofi, Chilly-Mazarin, France) ; Allez, Matthieu (Hôpital Saint-Louis, AP-HP) ; Deisenhammer, Florian (Innsbruck Medical University) ; Fogdell-Hahn, Anna (Karolinska Institutet (Estocolm, Suècia)) ; Mariette, Xavier (Université Paris-Saclay) ; Pallardy, Marc (Paris-Sud University) ; Broët, Philippe (Paris-Sud University Hospitals) ; Universitat Autònoma de Barcelona
Biopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our knowledge of patient-related factors influencing the occurrence of antidrug antibodies (ADAs) is still limited. [...]
2020 - 10.1371/journal.pmed.1003348
PLoS Medicine, Vol. 17 (october 2020)  
5.
15 p, 1.2 MB CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS / Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matute-Blanch, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Osman, Mohamoud (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pinteac, Rucsanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Miró, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brito, Verónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dujmovic, Irena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Voortman, Margarete (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Khalil, Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Borràs, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sabidó, Eduard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Issazadeh-Navikas, Shohreh (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
To identify biomarkers associated with progressive phases of MS and with neuroprotective potential. Combined analysis of the transcriptional and proteomic profiles obtained in CNS tissue during chronic progressive phases of experimental autoimmune encephalomyelitis (EAE) with the transcriptional profile obtained during the differentiation of murine neural stem cells into neurons. [...]
2021 - 10.1212/NXI.0000000000000941
Neurology® neuroimmunology & neuroinflammation, Vol. 8 (january 2021)  
6.
12 p, 774.2 KB Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study / Leurs, C. E. ; Twaalfhoven, HAM ; Lissenberg-Witte, B. I. ; van Pesch, V ; Dujmovic, Irena ; Drulovic, Jelena ; Castellazzi, M. ; Bellini, T. ; Pugliatti, M. ; Kuhle, Jens ; Villar, L. M. ; Alvarez-Cermeño, José C ; Alvarez-Lafuente, Roberto ; Hegen, Harald ; Deisenhammer, Florian ; Walchhofer, L. M. ; Thouvenot, Eric ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, X (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vécsei, L. ; Rajda, C. ; Galimberti, Daniela ; Scarpini, E. ; Altintas, Ayse ; Rejdak, K. ; Frederiksen, J. L. ; Pihl-Jensen, G. ; Jensen, PEH ; Khalil, Michael ; Voortman, Margarete ; Fazekas, F. ; Saiz, Albert ; La Puma, D. ; Vercammen, M. ; Vanopdenbosch, L. ; Uitdehaag, BMJ ; Killestein, Joep ; Bridel, C. ; Teunissen, Charlotte E. ; Universitat Autònoma de Barcelona
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. [...]
2019 - 10.1177/1352458519845844
Multiple sclerosis, Vol. 26 (may 2019) , p. 912-923  
7.
16 p, 688.9 KB Consensus guidelines for lumbar puncture in patients with neurological diseases / Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ; Niemantsverdriet, Ellis (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Struyfs, Hanne (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Blennow, Kaj (Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden) ; Brouns, Raf (Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Dujmovic, Irena (Clinic of Neurology, Clinical Centre of Serbia, Department of Neurology, Faculty of Medicine, University of Belgrade School of Medicine, Belgrade, Serbia) ; van der Flier, Wiesje (Amsterdam UMC. University Medical Center) ; Frölich, Lutz (Central Institute of Mental Health (Manheim, Alemanya)) ; Galimberti, Daniela (Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Hemmer, Bernhard (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ; Hoff, Erik (Department of Neurology, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands) ; Hort, Jakub (International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic) ; Iacobaeus, Ellen (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Ingelsson, Martin (Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden) ; Jan de Jong, Frank (Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands) ; Jonsson, Michael (Sahlgrenska University Hospital (Suècia)) ; Khalil, Michael (Department of Neurology, Medical University Graz, Graz, Austria) ; Kuhle, Jens (University Hospital Basel (Basilea, Suïssa)) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; de Mendonça, Alexandre (Laboratory of Neurosciences, Department of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal) ; Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Nagels, Guy (National MS Center Melsbroek, Brussels, Belgium) ; Paquet, Claire (Research Memory Center Lariboisière Hospital University Paris Diderot INSERMU942, Paris, France) ; Parnetti, Lucilla (Section of Neurology, Centre for Memory Disturbances, Department of Medicine, University of Perugia, Perugia, Italy) ; Roks, Gerwin (Department of Neurology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands) ; Rosa-Neto, Pedro (Departments of Psychiatry, McGill Centre for Studies in Aging, Douglas Hospital Research Center, McGill University, Montreal, Canada) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; Skårsgard, Constance (Department of Geriatrics, Kalmar County Hospital, Kalmar, Sweden) ; Stomrud, Erik (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ; Tumani, Hayrettin (CSF Laboratory and Multiple Sclerosis Outpatient Unit, Department of Neurology, University of Ulm, Ulm, Germany) ; Visser, Pieter Jelle (Maastricht University. Department of Psychiatry and Neuropsychology) ; Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ; Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). Department of Molecular Neuroscience) ; Duits, Flora (Amsterdam UMC. University Medical Center) ; Teunissen, Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ; Universitat Autònoma de Barcelona
Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. [...]
2017 - 10.1016/j.dadm.2017.04.007
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 8 (may 2017) , p. 111-126  

See also: similar author names
1 Khalil, M. I.
1 Khalil, M.I.
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