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Resultats globals: 5 registres trobats en 0.01 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
14 p, 4.0 MB Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models / Sharp, Paul S. (University of Manchester. Nanomedicine Lab) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab) ; Arellano, Luis M. (Institut Català de Nanociència i Nanotecnologia) ; Neves, Juliana C. (Institut Català de Nanociència i Nanotecnologia) ; Gravagnuolo, Alfredo M. (University of Manchester. Nanomedicine Lab) ; Dodd, Abbie (University of Manchester. Nanomedicine Lab) ; Barr, Katharine (University of Manchester. Nanomedicine Lab) ; Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ; Kisby, Thomas (University of Manchester. Nanomedicine Lab) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. [...]
2023 - 10.1002/adhm.202201968
Advanced Healthcare Materials, Vol. 12, Issue 3 (January 2023) , art. 2201968  
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2.
12 p, 3.7 MB Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge / Shin, Yuyoung (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab) ; Just-Baringo, Xavier (University of Manchester. Department of Chemistry) ; Gali, Sai Manoj (Institut Català de Nanociència i Nanotecnologia) ; Kisby, Thomas (University of Manchester. National Graphene Institute) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Gkoutzidou, Alexandra (University of Manchester. Department of Materials) ; Prestat, Eric (SciTech Daresbury Campus. SuperSTEM Laboratory) ; Beljonne, David (Institut Català de Nanociència i Nanotecnologia) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry)
The outstanding properties of graphene offer high potential for biomedical applications. In this framework, positively charged nanomaterials show better interactions with the biological environment, hence there is strong interest in the production of positively charged graphene nanosheets. [...]
2020 - 10.1039/d0nr02689a
Nanoscale, Vol. 12, Issue 23 (June 2020) , p. 12383-12394  
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3.
22 p, 4.5 MB Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state / Kisby, Thomas (University of Manchester. Nanomedicine Lab) ; de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab) ; Cossu, Giulio (University of Manchester. Division of Cell Matrix Biology and Regenerative Medicine) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
In contrast to mammals, lower vertebrates are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through forced expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM). [...]
2021 - 10.1371/journal.pone.0251054
PloS one, Vol. 16, Issue 5 (May 2021) , p. e0251054  
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4.
9 p, 4.9 MB Adenoviral mediated delivery of OSKM factors induces partial reprogramming of mouse cardiac cells in vivo / Kisby, Thomas (The University of Manchester. Nanomedicine Lab.) ; de Lázaro, Irene (Wyss Institute for Biologically Inspired Engineering at Harvard University. Center for Life Science) ; Fisch, Sudeshna (Harvard Medical School) ; Cartwright, Elizabeth J. (Manchester Academic Health Science Centre) ; Cossu, Giulio (The University of Manchester. Faculty of Biology, Medicine and Health) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
The induction of in vivo reprogramming toward pluripotency has been demonstrated in several tissues utilizing either transgenic inducible mice or gene delivery approaches. However, the effects of exogenous reprogramming factor expression in the mammalian heart have not been previously reported. [...]
2021 - 10.1002/adtp.202000141
Advanced Therapeutics, Vol. 4, issue 2 (Feb. 2021) , art. 2000141  
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5.
15 p, 2.5 MB Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model / de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ; Sharp, Paul (University of Manchester. Nanomedicine Lab.) ; Gurcan, Cansu (Ankara University. Department of Biomedical Engineering) ; Ceylan, Ahmed (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab.) ; Kisby, Thomas (University of Manchester. Nanomedicine Lab.) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab.) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab.) ; Barr, Katharine (University of Manchester. Nanomedicine Lab.) ; Taheri, Hadiseh (Ankara University. Department of Biomedical Engineering) ; Ozen, Asuman (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Bussy, Cyrill (University of Manchester. Nanomedicine Lab.) ; Yilmazer, Acelya (Ankara University. Department of Biomedical Engineering) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Its anatomical localization, a highly heterogeneous and drug-resistant tumor cell population and a "cold" immune microenvironment, all challenge the treatment of glioblastoma. Nanoscale drug delivery systems, including graphene oxide (GO) flakes, may circumvent some of these issues bypassing biological barriers, delivering multiple cargoes to impact several pathways simultaneously, or targeting the immune compartment. [...]
2021 - 10.1002/adtp.202000109
Advanced Therapeutics, Vol. 4, issue 1 (Jan. 2021) , art. 2000109  
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