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14 p, 2.6 MB miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea / Martínez Martínez, Cristina (Hospital Universitari Vall d'Hebron) ; Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron) ; Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron) ; Stanifer, Megan L. (University of Heidelberg) ; Klaus, Bernd (European Molecular Biology Laboratory (EMBL)) ; Granzow, Martin (Institute of Human Genetics, University of Heidelberg) ; González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Salvo-Romero, Eloisa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso Cotoner, Carmen (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron) ; Roeth, Ralph (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ; Rappold, Gudrun (Institute of Human Genetics, University of Heidelberg) ; Huber, Wolfgang (European Molecular Biology Laboratory (EMBL)) ; González-Silos, Rosa (Institute of Medical Biometry and Informatics, University of Heidelberg) ; Lorenzo, Justo (Institute of Medical Biometry and Informatics, University of Heidelberg) ; Torres, Inés de (Hospital Universitari Vall d'Hebron) ; Azpiroz Vidaur, Fernando (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Boulant, Steeve (Research Group 'Cellular Polarity and Viral Infection' (F140), German Cancer Research Center (DKFZ)) ; Vicario, María (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ; Niesler, Beate (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ; Santos, Javier (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network)
Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epithelial barrier in patients with diarrhoea-predominant IBS (IBS-D). [...]
2017 - 10.1136/gutjnl-2016-311477
Gut, Vol. 66 (january 2017) , p. 1537-1538  
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