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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, C.M. (University of Washington) ;
Bone, W.P. (University of Pennsylvania) ;
Martin-Bornez, M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, B.F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, A.C. ;
Damrauer, S.M. ;
de Vries, P.S. ;
Smith, N.L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, A. ;
Heath, A.S. ;
Morrison, A.C. ;
Reiner, A.P. ;
Johnson, A. ;
Richmond, A. ;
Peters, A. ;
van Hylckama Vlieg, A. ;
McKnight, B. ;
Psaty, B.M. ;
Hayward, C. ;
Ward-Caviness, C. ;
O'Donnell, C. ;
Chasman, D. ;
Strachan, D.P. ;
Tregouet, D.A. ;
Mook-Kanamori, D. ;
Gill, D. ;
Thibord, F. ;
Asselbergs, F.W. ;
Leebeek, F.W.G. ;
Rosendaal, F.R. ;
Davies, G. ;
Homuth, G. ;
Temprano, G. ;
Campbell, H. ;
Taylor, H.A. ;
Bressler, J. ;
Huffman, J.E. ;
Rotter, J.I. ;
Yao, J. ;
Wilson, J.F. ;
Bis, J.C. ;
Hahn, J.M. ;
Desch, K.C. ;
Wiggins, K.L. ;
Raffield, L.M. ;
Bielak, L.F. ;
Yanek, L.R. ;
Kleber, M.E. ;
Mueller, M. ;
Kavousi, M. ;
Mangino, M. ;
Liu, M. ;
Brown, M.R. ;
Conomos, M.P. ;
Jhun, M.A. ;
Chen, M.H. ;
de Maat, M.P.M. ;
Pankratz, N. ;
Smith, N.L. ;
Peyser, P.A. ;
Elliot, P. ;
Wei, P. ;
Wild, P.S. ;
Morange, P.E. ;
van der Harst, P. ;
Yang, Q. ;
Le, N.Q. ;
Marioni, R. ;
Li, R. ;
Damrauer, S.M. ;
Cox, S.R. ;
Trompet, S. ;
Felix, S.B. ;
Völker, U. ;
Tang, W. ;
Koenig, W. ;
Jukema, J.W. ;
Guo, X. ;
Lindstrom, S. ;
Wang, L. ;
Smith, E.N. ;
Gordon, W. ;
van Hylckama Vlieg, A. ;
de Andrade, M. ;
Brody, J.A. ;
Pattee, J.W. ;
Haessler, J. ;
Brumpton, B.M. ;
Suchon, P. ;
Chen, M.H. ;
Turman, C. ;
Germain, M. ;
Wiggins, K.L. ;
MacDonald, J. ;
Braekkan, S.K. ;
Armasu, S.M. ;
Pankratz, N. ;
Jackson, R.D. ;
Nielsen, J.B. ;
Giulianini, F. ;
Puurunen, M.K. ;
Ibrahim, M. ;
Heckbert, S.R. ;
Bammler, T.K. ;
Frazer, K.A. ;
McCauley, B.M. ;
Taylor, K. ;
Pankow, James S ;
Reiner, A.P. ;
Gabrielsen, M.E. ;
Deleuze, J.F. ;
O'Donnell, C.J. ;
Kim, J. ;
McKnight, B. ;
Kraft, P. ;
Hansen, J.B. ;
Rosendaal, F.R. ;
Heit, J.A. ;
Psaty, B.M. ;
Tang, W. ;
Kooperberg, C. ;
Hveem, K. ;
Ridker, P.M. ;
Morange, P.E. ;
Johnson, A.D. ;
Kabrhel, C. ;
Trégouët, D.A. ;
Smith, N.L. ;
Malik, R. ;
Chauhan, G. ;
Traylor, M. ;
Sargurupremraj, M. ;
Okada, Y. ;
Mishra, A. ;
Rutten-Jacobs, L. ;
Giese, A.K. ;
van der Laan, S.W. ;
Gretarsdottir, S. ;
Anderson, C. D. ;
Chong, M. ;
Adams, H.H.H. ;
Ago, T. ;
Almgren, P. ;
Amouyel, P. ;
Ay, H. ;
Bartz, T.M. ;
Benavente, O.R. ;
Bevan, S. ;
Boncoraglio, G.B. ;
Brown, R.D. ;
Butterworth, A.S. ;
Carrera, C. ;
Carty, C.L. ;
Chen, W.M. ;
Cole, J.W. ;
Correa, A. ;
Cotlarciuc, I. ;
Cruchaga, C. ;
Danesh, J. ;
de Bakker, P.I.W. ;
DeStefano, A.L. ;
den Hoed, M. ;
Duan, Q. ;
Engelter, S.T. ;
Falcone, G.J. ;
Gottesman, R.F. ;
Grewal, R.P. ;
Gudnason, V. ;
Gustafsson, S. ;
Haessler, J. ;
Harris, T.B. ;
Hassan, A. ;
Havulinna, A.S. ;
Heckbert, S.R. ;
Holliday, E.G. ;
Howard, G. ;
Hsu, F.C. ;
Hyacinth, H.I. ;
Arfan Ikram, M. ;
Ingelsson, E. ;
Irvin, M.R. ;
Jian, X. ;
Jiménez-Conde, J. ;
Johnson, J.A. ;
Jukema, J.W. ;
Kanai, M. ;
Keene, K.L. ;
Kissela, B.M. ;
Kleindorfer, D.O. ;
Kooperberg, C. ;
Kubo, M. ;
Lange, L.A. ;
Langefeld, C.D. ;
Langenberg, C. ;
Launer, L.J. ;
Lee, J.M. ;
Lemmens, R. ;
Leys, D. ;
Lewis, C.M. ;
Lin, W.Y. ;
Lindgren, A.G. ;
Lorentzen, E. ;
Magnusson, P.K. ;
Maguire, J. ;
Manichaikul, A. ;
McArdle, P.F. ;
Meschia, J.F. ;
Mitchell, B.D. ;
Mosley, T.H. ;
Nalls, M.A. ;
Ninomiya, T. ;
O'Donnell, M.J. ;
Psaty, B.M. ;
Pulit, S.L. ;
Rannikmäe, K. ;
Reiner, A.P. ;
Rexrode, K.M. ;
Rice, K. ;
Rich, S.S. ;
Ridker, P.M. ;
Rost, N.S. ;
Rothwell, P.M. ;
Rotter, J.I. ;
Rundek, T. ;
Sacco, R.L. ;
Sakaue, S. ;
Sale, M.M. ;
Salomaa, V. ;
Sapkota, B.R. ;
Schmidt, R. ;
Schmidt, C.O. ;
Schminke, U. ;
Sharma, P. ;
Slowik, A. ;
Sudlow, C.L.M. ;
Tanislav, C. ;
Tatlisumak, T. ;
Taylor, K.D. ;
Thijs, V.N.S. ;
Thorleifsson, G. ;
Thorsteinsdottir, U. ;
Tiedt, S. ;
Trompet, S. ;
Tzourio, C. ;
van Duijn, C.M. ;
Walters, M. ;
Wareham, N.J. ;
Wassertheil-Smoller, S. ;
Wilson, J.G. ;
Wiggins, K.L. ;
Yang, Q. ;
Yusuf, S. ;
Amin, N. ;
Aparicio, H.S. ;
Arnett, D.K. ;
Attia, J. ;
Beiser, A.S. ;
Berr, C. ;
Buring, J.E. ;
Bustamante, M. ;
Caso, V. ;
Cheng, Y.C. ;
Hoan Choi, S. ;
Chowhan, A. ;
Cullell, N. ;
Dartigues, J.F. ;
Delavaran, H. ;
Delgado, P. ;
Dörr, M. ;
Engström, G. ;
Ford, I. ;
Gurpreet, W.S. ;
Hamsten, A. ;
Heitsch, L. ;
Hozawa, A. ;
Ibanez, L. ;
Ilinca, A. ;
Ingelsson, M. ;
Iwasaki, M. ;
Jackson, R.D. ;
Jood, K. ;
Jousilahti, P. ;
Kaffashian, S. ;
Kalra, L. ;
Kamouchi, M. ;
Kitazono, T. ;
Kjartansson, O. ;
Kloss, M. ;
Koudstaal, P.J. ;
Krupinski, J. ;
Labovitz, D.L. ;
Laurie, C.C. ;
Levi, C.R. ;
Li, L. ;
Lind, L. ;
Lindgren, C.M. ;
Lioutas, V. ;
Mei Liu, Y. ;
Lopez, O.L. ;
Makoto, H. ;
Martinez-Majander, N. ;
Matsuda, K. ;
Minegishi, N. ;
Montaner, J. ;
Morris, A.P. ;
Muiño, E. ;
Müller-Nurasyid, M. ;
Norrving, B. ;
Ogishima, S. ;
Parati, E.A. ;
Reddy Peddareddygari, L. ;
Pedersen, N.L. ;
Pera, J. ;
Perola, M. ;
Pezzini, A. ;
Pileggi, S. ;
Rabionet, R. ;
Riba-Llena, I. ;
Ribasés, M. ;
Romero, J.R. ;
Roquer, J. ;
Rudd, A.G. ;
Sarin, A.P. ;
Sarju, R. ;
Sarnowski, C. ;
Sasaki, M. ;
Satizabal, C.L. ;
Satoh, M. ;
Sattar, N. ;
Sawada, N. ;
Sibolt, G. ;
Sigurdsson, Á. ;
Smith, A. ;
Sobue, K. ;
Soriano-Tárraga, C. ;
Stanne, T. ;
Colin Stine, O. ;
Stott, D.J. ;
Strauch, K. ;
Takai, T. ;
Tanaka, H. ;
Tanno, K. ;
Teumer, A. ;
Tomppo, L. ;
Torres-Aguila, N.P. ;
Touze, E. ;
Tsugane, S. ;
Uitterlinden, A.G. ;
Valdimarsson, E.M. ;
van der Lee, S.J. ;
Völzke, H. ;
Wakai, K. ;
Weir, D. ;
Williams, S.R. ;
Wolfe, C.D.A. ;
Wong, Q. ;
Xu, H. ;
Yamaji, T. ;
Sanghera, D.K. ;
Melander, O. ;
Jern, C. ;
Strbian, D. ;
Fernandez-Cadenas, I. ;
Longstreth, W.T. ;
Rolfs, A. ;
Hata, J. ;
Woo, D. ;
Rosand, J. ;
Pare, G. ;
Hopewell, J.C. ;
Saleheen, D. ;
Stefansson, K. ;
Worrall, B.B. ;
Kittner, S.J. ;
Seshadri, S. ;
Fornage, M. ;
Markus, H. S. ;
Howson, J.M.M. ;
Kamatani, Y. ;
Debette, S. ;
Dichgans, M. ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 -  10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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10 p, 806.0 KB |
Detailed phenotyping of posterior vs. anterior circulation ischemic stroke : a multi-center MRI study
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Frid, Petrea (Skåne University Hospital (Suècia)) ;
Drake, Mattias (Skåne University Hospital (Suècia)) ;
Giese, A. K. (Massachusetts Institute of Technology (MIT). Broad Institute) ;
Wasselius, J. (Skåne University Hospital (Suècia)) ;
Schirmer, M. D. (German Centre for Neurodegenerative Diseases (DZNE). Department of Population Health Sciences) ;
Donahue, K. L. (Harvard Medical School) ;
Cloonan, Lisa (Harvard Medical School) ;
Irie, R. (Harvard Medical School) ;
Bouts, Mark (Harvard Medical School) ;
McIntosh, E. C. (Harvard Medical School) ;
Mocking, S. J. T. (Harvard Medical School) ;
Dalca, Adrian Vasile (Harvard Medical School) ;
Sridharan, Ramesh (Massachusetts Institute of Technology (MIT). Computer Science and Artificial Intelligence Laboratory) ;
Xu, H. (University of Maryland School of Medicine) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia)) ;
Jood, Katarina (Sahlgrenska University Hospital (Suècia)) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cole, John W. (University of Maryland School of Medicine) ;
McArdle, P. F. (University of Maryland School of Medicine) ;
Broderick, Joseph P (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jern, C. (The Sahlgrenska Academy at University of Gothenburg. Institute of Biomedicine) ;
Kissela, B. M. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Kleindorfer, D. O. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Lemmens, R. (University Hospitals Leuven (Bèlgica)) ;
Meschia, J. F. (Mayo Clinic. Department of Neurology) ;
Rundek, T. (University of Miami. Department of Neurology) ;
Sacco, R. L. (University of Miami. Department of Neurology) ;
Schmidt, Reinhold (Medical University Graz. Clinical Division of Neurogeriatrics, Department of Neurology) ;
Sharma, P. (Ashford and St Peter's Hospital (Ashford, Regne Unit)) ;
Slowik, A. (Jagiellonian University Medical College. Department of Neurology) ;
Thijs, V. (Austin Health. Department of Neurology) ;
Woo, D. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Worrall, B. B. (University of Virginia. Department of Public Health Sciences) ;
Kittner, S. J. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System. Department of Neurology) ;
Mitchell, B. D. (Veterans Administration Medical Center. Geriatric Research and Education Clinical Center) ;
Petersson, J. (Skåne University Hospital (Suècia)) ;
Rosand, J. (Massachusetts General Hospital (Boston)) ;
Golland, P. (Massachusetts Institute of Technology (MIT). Computer Science and Artificial Intelligence Laboratory) ;
Wu, O. (Harvard Medical School) ;
Rost, N. S. (Massachusetts General Hospital (Boston)) ;
Lindgren, A. (Skåne University Hospital (Suècia)) ;
Universitat Autònoma de Barcelona
Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. [...]
2019 - 10.1007/s00415-019-09613-5
Journal of Neurology, Vol. 267 (november 2019) , p. 649-658
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