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135 p, 1.9 MB |
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
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Lewczuk, Piotr (University Hospital of Białystok) ;
Riederer, Peter (University Hospital Würzburg) ;
O'Bryant, Sid E. (University of North Texas Health Science Center) ;
Verbeek, Marcel M. (Radboud Alzheimer center) ;
Dubois, Bruno (Salpêtrièrie Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Jellinger, Kurt A. (Institute of Clinical Neurobiology) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Ramirez, Alfredo (University of Cologne) ;
Parnetti, Lucilla (University of Perugia) ;
Jack Jr, Clifford R. (Mayo Clinic) ;
Teunissen, Charlotte E. (VU University Medical Center Amsterdam) ;
Hampel, Harald (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Jessen, Frank (German Center for Neurodegenerative Disorders (DZNE)) ;
Glodzik, Lidia (NYU Langone Medical Center) ;
de Leon, Mony J. (NYU Langone Medical Center) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Jansen, Willemijn J. (Maastricht University) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Andreasson, Ulf (The Sahlgrenska Academy at the University of Gothenburg) ;
Otto, Markus (University of Ulm) ;
Mollenhauer, Brit (Kassel and University Medical Center Göttingen) ;
Wiltfang, Jens (University of Aveiro) ;
Turner, Martin R. (University of Oxford) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Handels, Ron (Karolinska Institutet (Estocolm, Suècia)) ;
Thompson, Alexander G. (University of Oxford) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Ermann, Natalia (Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Karaca, Ilker (University of Bonn) ;
Wagner, Holger (University of Bonn) ;
Oeckl, Patrick (University of Ulm) ;
van Waalwijk van Doorn, Linda (Radboud Alzheimer center) ;
Bjerke, Maria (University of Antwerp) ;
Kapogiannis, Dimitrios (National Institute on Aging/National Institutes of Health (NIA/NIH)) ;
Kuiperij, H.Bea (Radboud Alzheimer center) ;
Farotti, Lucia (University of Perugia) ;
Li, Yi (NYU Langone Medical Center) ;
Gordon, Brian A. (Washington University School of Medicine) ;
Epelbaum, Stéphane (Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A)) ;
Vos, Stephanie J.B. (Maastricht University) ;
Klijn, Catharina J.M. (Radboud Alzheimer Center) ;
Van Nostrand, William E. (Stony Brook University) ;
Minguillon, Carolina (Fundació Pasqual Maragall) ;
Schmitz, Matthias (University Medical School) ;
Gallo, Carla (Universidad Peruana Cayetano Heredia) ;
Lopez Mato, Andrea (Maimonides University) ;
Thibaut, Florence (University Hospital Cochin-Site Tarnier 89 rue d'Assas) ;
Lista, Simone (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Kornhuber, Johannes (Universitätsklinikum Erlangen) ;
Universitat Autònoma de Barcelona
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. [...]
2018 -  10.1080/15622975.2017.1375556
World Journal of Biological Psychiatry, Vol. 19 Núm. 4 (19 2018) , p. 244-328
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10 p, 855.6 KB |
Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer's disease, but not in cerebral amyloid angiopathy
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De Kort, A.M. (Department of Neurology. Radboud University Medical Center. Donders Institute for Brain. Cognition and Behaviour. Radboud Alzheimer Centre) ;
Kuiperij, H.B. (Department of Neurology. Radboud University Medical Center. Donders Institute for Brain. Cognition and Behaviour. Radboud Alzheimer Centre) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Kersten, I. (Department of Neurology. Radboud University Medical Center. Donders Institute for Brain. Cognition and Behaviour. Radboud Alzheimer Centre) ;
Versleijen, A.A.M. (Department of Laboratory Medicine. Radboud University Medical Center) ;
Greenberg, S.M. (Massachusetts General Hospital (Boston)) ;
Stoops, E. (ADx NeuroSciences) ;
Schreuder, F.H.B.M. (Department of Neurology. Radboud University Medical Center. Donders Institute for Brain. Cognition and Behaviour. Radboud Alzheimer Centre) ;
Klijn, C.J.M. (Department of Neurology. Radboud University Medical Center. Donders Institute for Brain. Cognition and Behaviour. Radboud Alzheimer Centre) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Claassen, Jurgen A. H. R (Radboud University Medical Centre. Department of Geriatrics) ;
Verbeek, M.M. (Department of Laboratory Medicine. Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Background: Neuroleukin (NLK) is a protein with neurotrophic properties and is present in a proportion of senile plaques and amyloid laden vessels. It has been suggested that NLK is part of a neuroprotective response to amyloid β-induced cell death. [...]
2021 - 10.1186/s13195-021-00899-0
Alzheimer's research & therapy, Vol. 13 Núm. 1 (december 2021) , p. 160
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12 p, 544.9 KB |
Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis
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Marini, Sandro (Massachusetts General Hospital (Boston)) ;
Crawford, Katherine (Massachusetts General Hospital (Boston)) ;
Morotti, A. (Fondazione Mondino IRCCS, Pavia) ;
Lee, M. J. (Massachusetts General Hospital (Boston)) ;
Pezzini, Alessandro (Università degli Studi di Brescia) ;
Moomaw, C. J. (University of Cincinnati) ;
Flaherty, M. L. (University of Cincinnati) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Slowik, A. (Jagiellonian University Medical College, Kraków) ;
Jagiella, Jeremiasz M (Jagiellonian University Medical College, Kraków) ;
Pera, J. (Jagiellonian University Medical College, Kraków) ;
Urbanik, Andrzej (Jagiellonian University Medical College, Kraków) ;
Pichler, A. (Jagiellonian University Medical College, Kraków) ;
Hansen, Björn M (Lund University) ;
McCauley, J. L. (John P. Hussman Institute for Human Genomics, Miami) ;
Tirschwell, D. L. (University of Washington) ;
Selim, Magdy (Beth Israel Deaconess Medical Center, Boston) ;
Brown, D. L. (University of Michigan) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Worrall, B. B. (University of Virginia Health System) ;
Meschia, J. F. (Mayo Clinic, Jacksonville, Florida) ;
Kidwell, C. S. (University of Arizona) ;
Testai, F. D. (University of Illinois) ;
Kittner, S. J. (University of Maryland School of Medicine) ;
Schmidt, H. (Medical University of Graz) ;
Enzinger, C. (Medical University of Graz) ;
Deary, Ian J. (University of Edinburgh) ;
Rannikmae, K. (University of Edinburgh) ;
Samarasekera, N. (University of Edinburgh) ;
Salman, R. A. S. (University of Edinburgh) ;
Sudlow, C. L. (University of Edinburgh) ;
Klijn, C. J. M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Van Nieuwenhuizen, K. M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Norrving, B. (Lund University) ;
Lindgren, A. (Lund University) ;
Goldstein, J. N. (Massachusetts General Hospital (Boston)) ;
Viswanathan, Anand (Massachusetts General Hospital (Boston)) ;
Greenberg, S. M. (Massachusetts General Hospital (Boston)) ;
Falcone, G. J. (Yale University) ;
Biffi, Alessandro (Massachusetts General Hospital (Boston)) ;
Langefeld, Carl D (Wake Forest University, Winston-Salem, North Carolina) ;
Woo, D. (University of Cincinnati College of Medicine) ;
Rosand, J. (Massachusetts General Hospital (Boston)) ;
Anderson, C. D. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 - 10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491
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11 p, 168.8 KB |
Genetic variants in CETP increase risk of intracerebral hemorrhage
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Anderson, Christopher D. (Broad Institute of MIT and Harvard) ;
Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Phuah, Chia-Ling (Broad Institute of MIT and Harvard) ;
Radmanesh, Farid (Broad Institute of MIT and Harvard) ;
Brouwers, H. Bart (Broad Institute of MIT and Harvard) ;
Battey, Thomas W. K. (Broad Institute of MIT and Harvard) ;
Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ;
Peloso, Gina M. (Broad Institute of MIT and Harvard) ;
Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ;
Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ;
Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Selim, Magdy (Beth Israel Deaconess Medical Center) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Brown, Devin L. (University of Michigan Health System) ;
Worrall, Bradford B. (University of Virginia Health System) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Tirschwell, David L. (University of Washington) ;
Flaherty, Matthew L. (University of Cincinnati College of Medicine) ;
Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ;
Schmidt, Helena (Medical University Graz) ;
Hansen, Björn M. (Skåne University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ;
Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ;
Rannikmae, Kristiina (University of Edinburgh) ;
Samarasekera, Neshika (University of Edinburgh) ;
Salman, Rustam Al-Shahi (University of Edinburgh) ;
Sudlow, Catherine L. (University of Edinburgh) ;
Deary, Ian J. (University of Edinburgh) ;
Morotti, Andrea (Neurology Clinic, University of Brescia) ;
Pezzini, Alessandro (Neurology Clinic, University of Brescia) ;
Pera, Joanna (Jagiellonian University Medical College) ;
Urbanik, Andrzej (Jagiellonian University Medical College) ;
Pichler, Alexander (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Norrving, Bo (Skåne University Hospital (Suècia)) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lindgren, Arne (Skåne University Hospital (Suècia)) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Schmidt, Reinhold (Medical University of Graz) ;
Kidwell, Chelsea S. (University of Arizona) ;
Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ;
Waddy, Salina P. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Langefeld, Carl D. (Wake Forest University) ;
Abecasis, Goncalo (University of Michigan School of Public Health) ;
Willer, Cristen J. (University of Michigan Medical School) ;
Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Rosand, Jonathan (Broad Institute of MIT and Harvard) ;
Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of neurology, Vol. 80 (october 2016) , p. 730-740
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