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6 p, 380.2 KB Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer : final results of a randomised phase 2 clinical trial / Gridelli, Cesare (S.G. Moscati Hospital) ; Ciuleanu, Tudor Eliade (Institutui. Oncologic I. Chircuta) ; Domine, Manuel (Fundacion Jimenez Diaz) ; Szczesna, Aleksandra (Mazowieckie Centrum) ; Bover, Isabel (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ; Cobo, Manuel (Instituto de Investigaciones Biomédicas (IBIMA)) ; Kentepozidis, Nikolaos (251 General Airforce Hospital) ; Zarogoulidis, Konstantinos (Papanikolaou General Hospital) ; Kalofonos, Charalobos (University Hospital of Patras) ; Kazarnowisz, Andrzej (Oddzial Onkologiiz Pododdziatem) ; Korozan, Magdalena (Hospicjum Dutkiewicza SAC) ; de las Peñas, Ramon (Hospital Provincial de Castellon) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Chella, Antonio (A.O.U. di Pisa Hospital) ; Griesinger, Frank (Pius Hospital) ; Bournakis, Evangelos (University Hospital "Aretaieion") ; Sadjadian, Parvis (Johannes Wesling Klinikum) ; Kotsakis, Athanasios (University General Hospital of Larissa) ; Chinet, Thierry (Hopital Ambroise Paré) ; Syrigos, Kostantinos N. (General Hospital of Thoracic Diseases "Sotiria") ; Correale, Pierpaolo (University Hospital of Siena) ; Gallou, Catherine (Vaxon-Biotech) ; Jamet, Jeanne-Menez (Vaxon-Biotech) ; Vetsika, Eleni-Kyriaki (University General Hospital of Heraklion) ; Kosmatopoulos, Kostas (Vaxon-Biotech) ; Georgoulias, Vassilis (University General Hospital of Heraklion) ; Universitat Autònoma de Barcelona
The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with advanced/metastatic non-small cell lung cancer (NSCLC). [...]
2020 - 10.1038/s41416-020-0785-y
British Journal of Cancer, Vol. 122 Núm. 10 (december 2020) , p. 1461-1466  
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1 Kosmatopoulos, Kostas
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