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1.
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10 p, 1.5 MB |
Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model
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Tortella, Lorenza (International School for Advanced Studies) ;
Santini, Irene (International School for Advanced Studies) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Cellot, Giada (International School for Advanced Studies) ;
Ballerini, Laura (International School for Advanced Studies)
Small graphene oxide (s-GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro-disorders characterized by altered glutamatergic transmission. [...]
2023 -  10.1002/chem.202301762
Chemistry, Vol. 29, Issue 67 (December 2023) , art. e202301762
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2.
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14 p, 4.0 MB |
Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models
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Sharp, Paul S. (University of Manchester. Nanomedicine Lab) ;
Stylianou, Maria (University of Manchester. Nanomedicine Lab) ;
Arellano, Luis M. (Institut Català de Nanociència i Nanotecnologia) ;
Neves, Juliana C. (Institut Català de Nanociència i Nanotecnologia) ;
Gravagnuolo, Alfredo M. (University of Manchester. Nanomedicine Lab) ;
Dodd, Abbie (University of Manchester. Nanomedicine Lab) ;
Barr, Katharine (University of Manchester. Nanomedicine Lab) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kisby, Thomas (University of Manchester. Nanomedicine Lab) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Graphene-based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. [...]
2023 - 10.1002/adhm.202201968
Advanced Healthcare Materials, Vol. 12, Issue 3 (January 2023) , art. 2201968
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3.
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9 p, 3.8 MB |
Correlative radioimaging and mass spectrometry imaging : a powerful combination to study 14C-graphene oxide in vivo biodistribution
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Cazier, Hélène (Université Paris Saclay) ;
Malgorn, Carole (Université Paris Saclay) ;
Georgin, Dominique (Université Paris Saclay) ;
Fresneau, Nathalie (Université Paris Saclay) ;
Beau, Fabrice (Université Paris Saclay) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester) ;
Campidelli, Stéphane (Université Paris Saclay) ;
Pinault, Mathieu (Université Paris-Saclay) ;
Mayne-L'Hermite, Martine (Université Paris-Saclay) ;
Taran, Frédéric (Université Paris Saclay) ;
Junot, Christophe (Université Paris Saclay) ;
Fenaille, François (Université Paris Saclay) ;
Sallustrau, Antoine (Université Paris Saclay) ;
Colsch, Benoit (Université Paris Saclay)
Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the development of more efficient imaging techniques to track the fate of these materials. [...]
2023 - 10.1039/d2nr06753f
Nanoscale, Vol. 15, Issue 11 (March 2023) , p. 5510-5518
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4.
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17 p, 7.9 MB |
Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders
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Chen, Yingxian (University of Manchester. Nanomedicine Lab) ;
Taufiq, Tooba (The University of Manchester) ;
Zeng, Niting (University of Manchester. Department of Chemistry) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Karakasidi, Angeliki (University of Manchester. Nanomedicine Lab) ;
Church, Heather (Manchester Centre for Genomic Medicine) ;
Jovanovic, Ana (Salford Royal NHS Foundation Trust) ;
Jones, Simon A. (Manchester Centre for Genomic Medicine) ;
Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ;
Larrosa, Igor (University of Manchester. Department of Chemistry) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Casiraghi, Cinzia (University of Manchester. Department of Chemistry) ;
Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Enzyme replacement therapy shows remarkable clinical improvement in treating lysosomal storage disorders. However, this therapeutic approach is hampered by limitations in the delivery of the enzyme to cells and tissues. [...]
2023 - 10.1039/d2nr04971f
Nanoscale, Vol. 15, Issue 21 (June 2023) , p. 9348-9364
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5.
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17 p, 11.3 MB |
Lung Persistence, Biodegradation, and Elimination of Graphene-Based Materials are Predominantly Size-Dependent and Mediated by Alveolar Phagocytes
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Loret, Thomas (University of Manchester. Nanomedicine Lab) ;
De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre) ;
Lucherelli, Matteo Andrea (University of Strasbourg) ;
Fordham, Alexander (University of Manchester. Nanomedicine Lab) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Bianco, Alberto (University of Strasbourg) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab)
Graphene-based materials (GBMs) have promising applications in various sectors, including pulmonary nanomedicine. Nevertheless, the influence of GBM physicochemical characteristics on their fate and impact in lung has not been thoroughly addressed. [...]
2023 - 10.1002/smll.202301201
Small, Vol. 19, Issue 39 (September 2023) , art. 2301201
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6.
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14 p, 2.2 MB |
Graphene Oxide Nanosheets Reduce Astrocyte Reactivity to Inflammation and Ameliorate Experimental Autoimmune Encephalomyelitis
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Di Mauro, Giuseppe (Scuola Internazionale Superiore di Studi Avanzati) ;
Amoriello, Roberta (University of Florence) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Carnasciali, Alberto (University of Florence) ;
Guasti, Daniele (University of Florence) ;
Becucci, Maurizio (University of Florence) ;
Cellot, Giada (Scuola Internazionale Superiore di Studi Avanzati) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Ballerini, Clara (University of Florence) ;
Ballerini, Laura (Scuola Internazionale Superiore di Studi Avanzati)
In neuroinflammation, astrocytes play multifaceted roles that regulate the neuronal environment. Astrocytes sense and respond to pro-inflammatory cytokines (CKs) and, by a repertoire of intracellular Ca signaling, contribute to disease progression. [...]
2023 - 10.1021/acsnano.2c06609
ACS nano, Vol. 17, Issue 3 (February 2023) , p. 1965-1978
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7.
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16 p, 4.1 MB |
Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor
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Peng, Guotao (Karolinska Institutet (Estocolm, Suècia)) ;
Sinkko, Hanna M. (University of Helsinki. Human Microbiome Research Program (HUMI)) ;
Alenius, Harri (University of Helsinki. Human Microbiome Research Program (HUMI)) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bräutigam, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia))
The gut microbiome produces metabolites that interact with the aryl hydrocarbon receptor (AhR), a key regulator of immune homoeostasis in the gut ,. Here we show that oral exposure to graphene oxide (GO) modulates the composition of the gut microbiome in adult zebrafish, with significant differences in wild-type versus ahr2 -deficient animals. [...]
2023 - 10.1038/s41565-022-01260-8
Nature Nanotechnology, Vol. 18 (2023) , p. 42-48
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8.
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46 p, 5.7 MB |
The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice
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Jasim, Dhifaf (University of Manchester) ;
Newman, Leon (University of Manchester) ;
Rodrigues, Artur Filipe (University of Manchester) ;
Vacchi, Isabella A. (University of Strasbourg) ;
Lucherelli, Matteo Andrea (University of Strasbourg) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Ménard-Moyon, Cécilia (University of Strasbourg) ;
Bianco, Alberto (University of Strasbourg) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Although the use of graphene and 2-dimensional (2D) materials in biomedicine has been explored for over a decade now, there are still significant knowledge gaps regarding the fate of these materials upon interaction with living systems. [...]
2021 - 10.1016/j.jconrel.2021.08.028
Journal of Controlled Release, Vol. 338 (October 2021) , p. 330-340
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9.
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11 p, 9.3 MB |
Effects of lateral size, thickness, and stabilizer concentration on the cytotoxicity of defect-free graphene nanosheets : implications for biological applications
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Hu, Chen-Xia (University of Manchester. Department of Chemistry) ;
Read, Oliver (University of Manchester. Department of Chemistry) ;
Shin, Yuyoung (University of Manchester. Department of Chemistry) ;
Chen, Yingxian (University of Manchester. Nanomedicine Lab) ;
Wang, Jingjing (University of Manchester. Department of Chemistry) ;
Boyes, Matthew (University of Manchester. Department of Chemistry) ;
Zeng, Niting (University of Manchester. Department of Chemistry) ;
Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Larrosa, Igor (University of Manchester. Department of Chemistry) ;
Vranic, Sandra (University of Manchester. Nanomedicine Lab) ;
Casiraghi, Cinzia (University of Manchester. Department of Chemistry)
In this work, we apply liquid cascade centrifugation to highly concentrated graphene dispersions produced by liquid-phase exfoliation in water with an insoluble bis-pyrene stabilizer to obtain fractions containing nanosheets with different lateral size distributions. [...]
2022 - 10.1021/acsanm.2c02403
ACS applied nano materials, Vol. 5, issue 9 (Sep. 2022) , p. 12626-12636
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10.
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10 p, 5.9 MB |
Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats
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Franceschi Biagioni, Audrey (International School for Advanced Studies (Trieste, Itàlia)) ;
Cellot, Giada (International School for Advanced Studies (Trieste, Itàlia)) ;
Pati, Elisa (International School for Advanced Studies (Trieste, Itàlia)) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Casani, Raffaele (International School for Advanced Studies (Trieste, Itàlia)) ;
Coimbra, Norberto Cysne (Universidad de São Paulo. Department of Pharmacology) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Ballerini, Laura (International School for Advanced Studies (Trieste, Itàlia))
Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an unexpected translational potential of these nanomaterials to target selective synapses in vivo. [...]
2021 - 10.1016/j.biomaterials.2021.120749
Biomaterials, Vol. 271 (April 2021) , art. 120749
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