1.
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13 p, 1.1 MB |
Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques
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Kulkarni, Viraj (National Cancer Institute, Frederick, Maryland, United States of America) ;
Valentin, Antonio (National Cancer Institute, Frederick, Maryland, United States of America) ;
Rosati, Margherita (National Cancer Institute, Frederick, Maryland, United States of America) ;
Alicea, Cándido (National Cancer Institute, Frederick, Maryland, United States of America) ;
Singh, Ashish K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Jalah, Rashmi (National Cancer Institute, Frederick, Maryland, United States of America) ;
Broderick, Kate E. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Le Gall, Sylvie (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rolland, Morgane (University of Washington, Seattle, Washington, United States of America) ;
Mullins, James I. (University of Washington, Seattle, Washington, United States of America) ;
Pavlakis, George N. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Felber, Barbara K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24 gag elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited responses to these conserved elements in only 5 of 11 animals, targeting fewer CE per animal. [...]
2014 - 10.1371/journal.pone.0086254
PloS one, Vol. 9 (january 2014)
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2.
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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