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1.
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16 p, 5.1 MB |
MSIMEP : Predicting microsatellite instability from microarray DNA methylation tumor profiles
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Santamarina-García, Martín (University of Santiago de Compostela) ;
Brea-Iglesias, Jenifer (University of Santiago de Compostela) ;
Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Fuentes-Losada, Mar (University of Santiago de Compostela) ;
Caneiro-Gómez, Francisco Javier (University of Santiago de Compostela) ;
Vázquez-Bueno, Jose Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Lázare-Iglesias, Hector (University of Santiago de Compostela) ;
Fernández-Díaz, Natalia (University of Santiago de Compostela) ;
Sánchez-Rivadulla, Laura (Complejo Hospitalario Universitario de Ferrol) ;
Betancor, Yoel Z. (University of Santiago de Compostela) ;
Ferreiro-Pantín, Miriam (University of Santiago de Compostela) ;
Conesa-Zamora, Pablo (Santa Lucía University Hospital) ;
Antúnez-López, José Ramon (University of Santiago de Compostela) ;
Kawazu, Masahito (Chiba Cancer Center, Research Institute, Chiba, Japan) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Tubio, Jose M.C. (University of Santiago de Compostela) ;
López-López, Rafael (Centro de Investigación Biomédica en Red de Cáncer) ;
Ruiz-Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer)
Deficiency in DNA MMR activity results in tumors with a hypermutator phenotype, termed microsatellite instability (MSI). Beyond its utility in Lynch syndrome screening algorithms, today MSI has gained importance as predictive biomarker for various anti-PD-1 therapies across many different tumor types. [...]
2023 -  10.1016/j.isci.2023.106127
iScience, Vol. 26 Núm. 3 (february 2023)
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2.
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13 p, 1.2 MB |
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA
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Ruiz Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez Casanova, Aitor (Universidade de Santiago de Compostela) ;
Costa-Fraga, Nicolás (Universidade de Santiago de Compostela) ;
Bao Caamano, Aida (Universidade de Santiago de Compostela) ;
Álvarez Castro, Ana (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Carreras Presas, Martín (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Brozos Vázquez, Elena (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vidal Insua, Yolanda (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vázquez Rivera, Francisca (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Candamio Folgar, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Mosquera Presedo, Manuel (Universidade de Santiago de Compostela) ;
Lago Lestón, Ramón M. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Vázquez Bueno, José Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Sanz Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno Aguado, Víctor (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Goel, Ajay (City of Hope Comprehensive Cancer Center) ;
Castillo, Lourdes (Advanced Marker Discovery) ;
Martín, Ana C. (Advanced Marker Discovery) ;
Arroyo, Rocío (Advanced Marker Discovery) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crujeiras, Ana B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
López López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Diaz-Lagares, Angel (Complejo Hospitalario Universitario de Santiago de Compostela)
Background: Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility of promoter methylation of the long noncoding RNA LINC00473 as a noninvasive biomarker to detect colorectal cancer and associated precancerous lesions. [...]
2022 - 10.1186/s13148-022-01302-x
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 86
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3.
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16 p, 1.4 MB |
Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
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Masoumi, Farimah (Islamic Azad University) ;
Saraiva, Sofia M. (Centro de Investigación Biomédica en Red de Cáncer) ;
Bouzo, Belén L. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
López-López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Lagares, Angel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
de la Fuente, María (Centro de Investigación Biomédica en Red de Cáncer)
Long non-coding RNAs (lncRNAs) are an emerging group of RNAs with a crucial role in cancer pathogenesis. In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53-mediated DNA damage and the intracellular localization of the oncogenic YBX1 protein. [...]
2021 - 10.3390/pharmaceutics13091507
Pharmaceutics, Vol. 13 Núm. 9 (september 2021) , art. 1507
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4.
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20 p, 5.4 MB |
Integrating digital pathology with transcriptomic and epigenomic tools for predicting metastatic uterine tumor aggressiveness
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Sonzini, Giorgia (Universitat de València) ;
Granados-Aparici, Sofia (Universitat de València) ;
Sanegre, Sabina (Cancer CIBER) ;
Diaz-Lagares, Angel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Diaz-Martin, Juan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
de Andrea, Carlos (Clínica Universidad de Navarra) ;
Eritja, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
Bao Caamano, Aida (Universidade de Santiago de Compostela) ;
Costa-Fraga, Nicolás (Universidade de Santiago de Compostela) ;
García-Ros, David (Clínica Universidad de Navarra) ;
Salguero-Aranda, Carmen (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Davidson, Ben (Oslo University Hospital (Oslo, Noruega)) ;
López-López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Melero, Ignacio (Clínica Universidad de Navarra) ;
Navarro, Samuel (Cancer CIBER) ;
Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona) ;
De Álava, Enrique (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Noguera, Rosa (Cancer CIBER)
The incidence of new cancer cases is expected to increase significantly in the future, posing a worldwide problem. In this regard, precision oncology and its diagnostic tools are essential for developing personalized cancer treatments. [...]
2022 - 10.3389/fcell.2022.1052098
Frontiers in Cell and Developmental Biology, Vol. 10 (november 2022)
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5.
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26 p, 11.1 MB |
The role of clonal communication and heterogeneity in breast cancer
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Martín-Pardillos, A. (Centro de Investigación Biomédica en Red de Cáncer) ;
Valls Chiva, Á. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bande Vargas, G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hurtado Blanco, P. (Cancer Modelling Lab. Roche-CHUS Joint Unit) ;
Piñeiro Cid, R. (Cancer Modelling Lab. Roche-CHUS Joint Unit) ;
Guijarro, Pedro J (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hümmer, Stefan (Centro de Investigación Biomédica en Red de Cáncer) ;
Bejar Serrano, Eva (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodriguez-Casanova, A. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Diaz-Lagares, Angel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Miravet-Verde, S. (Centre de Regulació Genòmica) ;
Serrano, L. (Institució Catalana de Recerca i Estudis Avançats) ;
Lluch-Senar, M. (Centre de Regulació Genòmica) ;
Sebastian, V. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Bribian, A. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
López-Mascaraque, L. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
López-López, R. (Roche-CHUS Joint Unit. University Clinical Hospital of Santiago (CHUS)) ;
Ramón Y Cajal, S. (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which is further amplified through specific interactions between cancer cells. [...]
2019 - 10.1186/s12885-019-5883-y
BMC Cancer, Vol. 19 Núm. 1 (may 2019) , p. 666
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6.
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7 p, 176.2 KB |
Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients : an expert taskforce review
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García-Foncillas, Jesús (Hospital Universitario Fundación Jiménez Díaz) ;
Alba, Emilio (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Aranda Aguilar, Enrique (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Díaz-Rubio, Eduardo (Hospital Clínico San Carlos (Madrid)) ;
López López, R. (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Tabernero, Josep (Universitat Autònoma de Barcelona) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia)
The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. [...]
2017 - 10.1093/annonc/mdx501
Annals of oncology, Vol. 28 (september 2017) , p. 2943-2949
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7.
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12 p, 615.8 KB |
Human salivary microRNAs in Cancer
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Rapado-González, Óscar (Centro de Investigación Biomédica en Red de Cáncer) ;
Majem Cavaller, Blanca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muinelo-Romay, Laura (Centro de Investigación Biomédica en Red de Cáncer) ;
Álvarez-Castro, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
López-López, Rafael (Centro de Investigación Biomédica en Red de Cáncer) ;
Suárez-Cunqueiro, María Mercedes (Department of Surgery and Medical Surgical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Spain. Health Research Institute of Santiago (IDIS); Santiago de Compostela, Spain) ;
Universitat Autònoma de Barcelona
Circulating microRNAs (miRNAs) have emerged as excellent candidates for cancer biomarkers. Several recent studies have highlighted the potential use of saliva for the identification of miRNAs as novel biomarkers, which represents a great opportunity to improve diagnosis and monitor general health and disease. [...]
2018 - 10.7150/jca.21180
Journal of Cancer, Vol. 9 (january 2018) , p. 638-649
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8.
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18 p, 1.0 MB |
Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity
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Rapado-González, Óscar (Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain) ;
Majem Cavaller, Blanca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
López-López, Rafa (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Suárez-Cunqueiro, María Mercedes (Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain) ;
Universitat Autònoma de Barcelona
The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. [...]
2016 - 10.3390/ijms17091531
International journal of molecular sciences, Vol. 17 (september 2016)
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