Results overview: Found 3 records in 0.02 seconds.
Articles, 3 records found
Articles 3 records found  
1.
13 p, 1.8 MB Ligand chain length drives activation of lipid G protein-coupled receptors / Troupiotis-Tsaïlaki, Anastassia (Université Libre de Bruxelles. Laboratoire de Structure et Fonction des Membranes Biologiques) ; Zachmann, Julian (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; González-Gil, Inés (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; González, Ángel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Ortega Gutiérrez, Silvia (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; López-Rodríguez, María L. (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Govaerts, Cedric (Université Libre de Bruxelles. Laboratoire de Structure et Fonction des Membranes Biologiques)
Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G proteincoupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic head-group and a hydrophobic alkyl chain. [...]
2017 - 10.1038/s41598-017-02104-5
Scientific Reports, Vol. 7 (2017) , art. 2020  
2.
10 p, 1.2 MB A new serotonin 5-HT6 receptor antagonist with procognitive activity : importance of a halogen bond interaction to stabilize the binding / González-Vera, Juan A. (Universidad Complutense de Madrid.Departamento de Química Orgánica) ; Medina, Rocio A. (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Martín-Fontecha, Mar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; González Wong, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; De La Fuente, Tania (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Vázquez-Villa, Henar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; García-Cárceles, Javier (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Botta, Joaquín (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; McCormick, Peter J. (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; Benhamú, Bellida (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; López-Rodríguez, Maria L. (Universidad Complutense de Madrid. Departamento de Química Orgánica)
Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's disease and other pathologies associated with memory deficiency. [...]
2017 - 10.1038/srep41293
Scientific Reports, Vol. 7 (2017) , art. 41293  
3.
13 p, 4.6 MB A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines / Puig, Teresa (Institut d'Investigació Biomèdica (Girona)) ; Aguilar, Helena (Institut Català d'Oncologia) ; Cufí, Sílvia (Institut d'Investigació Biomèdica (Girona)) ; Oliveras, Glòria (Institut d'Investigació Biomèdica (Girona)) ; Turrado, Carlos (Universidad Complutense de Madrid) ; Ortega Gutiérrez, Silvia (Universidad Complutense de Madrid) ; Benhamú, Bellinda (Universidad Complutense de Madrid) ; López-Rodríguez, María Luz (Universidad Complutense de Madrid) ; Urruticoechea, Ander (Institut Català d'Oncologia) ; Colomer Bosch, Ramón (Centro Oncológico MD Anderson (Madrid))
Introduction: Inhibiting the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 (HER2) signaling pathways in models of simultaneous expression of FASN and HER2. [...]
2011 - 10.1186/bcr3077
Breast cancer research, Vol. 13, N. R131 (December 2011) , p. 1-13
4 documents

See also: similar author names
1 López-Rodríguez, Ma Carmen
1 López-Rodríguez, Manuel Jesús
2 López-Rodríguez, Maria L.
1 López-Rodríguez, María Luz
Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.