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Articles, 6 records found
Articles 6 records found  
1.
23 p, 3.2 MB Genotypic and Phenotypic Characterization of Staphylococcus aureus Isolates from the Respiratory Tract in Mechanically-Ventilated Patients / Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Laabei, Maisem (Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK) ; Sánchez-Herrero, Jose Francisco (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Young, Bernadette (John Radcliffe Hospital (Oxford, Regne Unit)) ; Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sumoy, Lauro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Plans, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Arméstar, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Staphylococcus aureus is a commensal and frequent colonizer of the upper respiratory tract. When mechanical ventilation disrupts natural defenses, S. aureus is frequently isolated from the lower airways, but distinguishing between colonization and infection is difficult. [...]
2021 - 10.3390/toxins13020122
Toxins, Vol. 13 (february 2021)  
Detailed record - Creative Commons
2.
15 p, 1.9 MB Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection / Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Edwards, A. M. (MRC Centre for Molecular Bacteriology and Infection. Imperial College London) ; Young, Bernadette (Nuffield Department of Medicine. Experimental Medicine Division. University of Oxford) ; Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Tobacco smoking represents the leading preventable cause of death worldwide. Smoking is a recognised risk factor for several pathologies and is detrimental to host immune surveillance and defence. However, the impact of smoking on microbial residents of the nasopharyngeal cavity, in contact with cigarette smoke (CS), is lacking. [...]
2019 - 10.1038/s41598-019-47258-6
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 10798  
Detailed record - Creative Commons
3.
9 p, 1.3 MB Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase / Stevens, Emily (Milner Centre for Evolution, Dept. of Biology and Biochemistry, University of Bath) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gardner, Stewart (School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln) ; Somerville, Greg A. (School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln) ; Massey, Ruth C. (School of Molecular and Cellular Medicine, University of Bristol) ; Universitat Autònoma de Barcelona
Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase signal independent of Agr. [...]
2017 - 10.1038/s41598-017-14110-8
Scientific reports, Vol. 7 (october 2017)  
Detailed record - Creative Commons
4.
17 p, 1.5 MB Assessment of the influence of direct tobacco smoke on infection and active TB management / Altet, Neus (Hospital Universitari Vall d'Hebron) ; Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ; Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ; Molina Romero, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ; González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ; Milà, Celia (Hospital Universitari Vall d'Hebron) ; García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Godoy, Pere (Generalitat de Catalunya. Departament de Salut) ; De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ; Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón) ; Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ; Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; PII Smoking SEPAR Working Group
Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. [...]
2017 - 10.1371/journal.pone.0182998
PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1  
Detailed record - Creative Commons
5.
14 p, 1.3 MB Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections / Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pagan Maldonado, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hidalgo, Jessica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Molinos Abós, Sònia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domínguez Villanueva, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jenkins, Andrew Toby A. (Department of Chemistry, University of Bath) ; Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Objective. Characterization of Staphylococcus aureus clinical isolates derived from lower respiratory tract infections (LRTIs), and correlation between the functionality of the accessory gene regulator (Agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome. [...]
2017 - 10.1371/journal.pone.0175552
PloS one, Vol. 12 Núm. 4 (2017) , p. 1-14  
Detailed record - Creative Commons
6.
15 p, 1.2 MB Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line / Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano, Victoria (Institut d'Investigació Sanitària de Palma) ; Moranta, D. (Institut d'Investigació Sanitària de Palma) ; Regueiro, Verónica (Institut d'Investigació Sanitària de Palma) ; Domínguez Villanueva, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; González-Nicolau, M. (Institut d'Investigació Sanitària de Palma) ; Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bengoechea, J. A. (Centre for Experimental Medicine, Queen's University Belfast) ; Universitat Autònoma de Barcelona
Objective : Staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. Previous studies have highlighted the intracellular capacity of S. aureus in several phagocytic and non-phagocytic cells. [...]
2017 - 10.1080/21505594.2017.1361089
Virulence, Vol. 8 (september 2017) , p. 1761-1775  
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