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1.
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10 p, 2.5 MB |
Myo5b knockout mice as a model of microvillus inclusion disease
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Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Overeem, Arend W. (University Medical Center Groningen) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 -  10.1038/srep12312
Scientific reports, Vol. 5 (07 2015)
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2.
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12 p, 2.3 MB |
Loss of the EPH receptor B6 contributes to colorectal cancer metastasis
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Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cacci, Karina (Hospital Universitari Vall d'Hebron) ;
Hernández-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Mariadason, John M. (La Trobe University) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports, Vol. 7 (03 2017)
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3.
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14 p, 2.1 MB |
Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer
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Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Brown, Arthur (Robarts Research Institute) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports, Vol. 7 (02 2017)
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4.
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10 p, 1.0 MB |
European guidelines on microscopic colitis : United European Gastroenterology and European Microscopic Colitis Group statements and recommendations
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Miehlke, Stephan (University Hospital Eppendorf) ;
Guagnozzi, Danila (Universitat Autònoma de Barcelona) ;
Zabana, Yamile (Universitat de Barcelona) ;
Tontini, Gian E. (University of Milan) ;
Kanstrup Fiehn, Anne-Marie (Copenhagen University Hospital) ;
Wildt, Signe (University of Copenhagen) ;
Bohr, Johan (Örebro University. Ö) ;
Bonderup, Ole (Regionshospitalet Silkeborg. H) ;
Bouma, Gerd (Vrije Universiteit Amsterdam) ;
D'Amato, Mauro (Monash University) ;
Heiberg Engel, Peter J. (Zealand University Hospital) ;
Fernandez-Bañares, Fernando (Universitat de Barcelona) ;
Macaigne, Gilles (Centre Hospitalier de Marne-la-Vallee) ;
Hjortswang, Henrik (Linköping University) ;
Hultgren-Hörnquist, Elisabeth (Örebro University) ;
Koulaouzidis, Anastasios (Endoscopy Unit) ;
Kupcinskas, Jouzas (Lithuanian University of Health Sciences) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Latella, Giovanni (University of L'Aquila) ;
Lucendo, Alfredo J. (Hospital General de Tomelloso) ;
Lyutakov, Ivan (University Hospital Tsaritsa Yoanna-ISUL) ;
Madisch, Ahmed (CRH Clinic Siloah) ;
Magro, Fernando (Hospital de São José (Lisboa, Portugal)) ;
Marlicz, Wojciech (Pomeranian Medical University) ;
Mihaly, Emese (Semmelweis University) ;
Munck, Lars K. (University of Copenhagen) ;
Ostvik, Ann-Elisabeth (St Olav's University Hospital) ;
Patai, Árpád V. (Mayo Clinic) ;
Penchev, Plamen (University Hospital Tsaritsa Yoanna-ISUL) ;
Skonieczna-Żydecka, Karolina (Pomeranian Medical University) ;
Verhaegh, Bas (Maastricht University Medical Center) ;
Münch, Andreas (Linköping University)
Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. [...]
2021 - 10.1177/2050640620951905
United European Gastroenterology Journal, Vol. 9 (february 2021) , p. 13-37
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5.
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13 p, 11.2 MB |
Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor - an update on neuroendocrine neoplasm's treatment : A case report
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Mirallas, Oriol (Vall d'Hebron Institut d'Oncologia) ;
Saoudi, Nadia (Vall d'Hebron Institut d'Oncologia) ;
Gomez-Puerto, Diego (Vall d'Hebron Institut d'Oncologia) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Merino, Xavier (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Blanco, Laia (Hospital Universitari Vall d'Hebron) ;
Garcia-Burillo, Amparo (Hospital Universitari Vall d'Hebron) ;
Molero, Xavier (Hospital Universitari Vall d'Hebron) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ;
Capdevila Castillón, Jaume (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Metastatic small bowel low-grade neuroendocrine tumors (NETs) have a good prognosis. Surgery is the only curative treatment; however, this may induce advanced liver disease, particularly in long-term survivor patients. [...]
2021 - 10.4254/wjh.v13.i5.611
World Journal of Hepatology, Vol. 13 (may 2021) , p. 611-619
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6.
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16 p, 1003.6 KB |
Update of the recommendations for the determination of biomarkers in colorectal carcinoma : National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
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García-Alfonso, Pilar (Hospital General Universitario Gregorio Marañón) ;
García-Carbonero, Rocío (Hospital Universitario 12 de Octubre (Madrid)) ;
García-Foncillas, Jesús (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Pérez-Segura, Pedro (Hospital Clínico San Carlos (Madrid)) ;
Salazar, R. (Centro de Investigación Biomédica en Red de Cáncer) ;
Vera, Ruth (Complejo Hospitalario de Navarra) ;
Ramón y Cajal, S. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Losa, J. (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Vall d'Hebron Institut d'Oncologia) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Navarro, S. (Hospital Clínic Universitari (València)) ;
Universitat Autònoma de Barcelona
In this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica-SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica-SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. [...]
2020 - 10.1007/s12094-020-02357-z
Clinical & Translational Oncology, Vol. 22 (may 2020) , p. 1976-1991
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7.
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10 p, 506.2 KB |
Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights
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Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ;
Elez, Elena (Hospital Universitari Vall d'Hebron) ;
Argilés Martínez, Guillem (Vall d'Hebron Institut d'Oncologia) ;
Matos, Ignacio (Vall d'Hebron Institut d'Oncologia) ;
Sanz García, Enrique (Vall d'Hebron Institut d'Oncologia) ;
Ortiz, Carolina (Vall d'Hebron Institut d'Oncologia) ;
Macarulla Mercadé, Teresa (Vall d'Hebron Institut d'Oncologia) ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
Alsina, Maria (Vall d'Hebron Institut d'Oncologia) ;
Saurí Nadal, Tamara (Vall d'Hebron Institut d'Oncologia) ;
Verdaguer, Helena (Vall d'Hebron Institut d'Oncologia) ;
Vilaró, Marta (Vall d'Hebron Institut d'Oncologia) ;
Ruiz-Pace, Fiorella (Vall d'Hebron Institut d'Oncologia) ;
Viaplana, Cristina (Vall d'Hebron Institut d'Oncologia) ;
García Rodríguez, Ariadna (Vall d'Hebron Institut d'Oncologia) ;
Landolfi, Stefania (Universitat Autònoma de Barcelona) ;
Palmer, Héctor G (Vall d'Hebron Institut d'Oncologia) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Rodón Ahnert, Jordi (Vall d'Hebron Institut d'Oncologia) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia)
Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (s, or the 'mutation dose') of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. [...]
2017 - 10.1002/1878-0261.12099
Molecular Oncology, Vol. 11, Issue 9 (September 2017) , p. 1263-1272
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