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11 p, 1.1 MB |
Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality
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Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital) ;
Varpula, Marjut (Helsinki) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Sund, Reijo (Helsinki) ;
Køber, Lars (Rigshospitalet) ;
Spinar, Jindrich (University Hospital Brno (República Txeca)) ;
Parissis, John (University General Hospital Attikon (Haidari, Grècia)) ;
Banaszewski, Marek (Institute of Cardiology) ;
Silva Cardoso, Jose (University of Porto) ;
Carubelli, Valentina (University and Civil Hospital of Brescia) ;
Di Somma, Salvatore (University of Rome Sapienza) ;
Mebazaa, Alexandre (Hopital Lariboisiere) ;
Harjola, Veli-Pekka (University of Helsinki) ;
Kober, Lars ;
Koniari, Katerina ;
Voumvourakis, Astrinos ;
Karavidas, Apostolos ;
Sans-Rosello, Jordi ;
Vila, Montserrat ;
Duran-Cambra, Albert ;
Metra, Marco ;
Bulgari, Michela ;
Lazzarini, Valentina ;
Parenica, Jiri ;
Stipal, Roman ;
Ludka, Ondrej ;
Palsuva, Marie ;
Ganovska, Eva ;
Kubena, Petr ;
Lindholm, Matias G. ;
Hassager, Christian ;
Bäcklund, Tom (Helsinki) ;
Jurkko, Raija (Helsinki) ;
Järvinen, Kristiina (Helsinki) ;
Nieminen, Tuomo (Helsinki) ;
Pulkki, Kari (Helsinki University Hospital (Finlàndia)) ;
Soininen, Leena (Helsinki) ;
Tierala, Ilkka (Helsinki) ;
Tolonen, Jukka (Helsinki) ;
Korva, Tuomas (Helsinki) ;
Pitkälä, Anne (Helsinki) ;
Marino, Rossella ;
Sousa, Alexandra ;
Sousa, Carla ;
Paiva, Mariana ;
Rangel, Inés ;
Almeida, Rui ;
Pinho, Teresa ;
Maciel, Maria Júlia ;
Stepinska, Janina ;
Skrobisz, Anna ;
Góral, Piotr ;
Universitat Autònoma de Barcelona
Vasopressors and inotropes remain a cornerstone in stabilization of the severely impaired hemodynamics and cardiac output in cardiogenic shock (CS). The aim of this study was to analyze current real-life use of these medications, and their impact on outcome and on changes in cardiac and renal biomarkers over time in CS. [...]
2016 -  10.1186/s13054-016-1387-1
Critical Care, Vol. 20 Núm. 1 (april 2016) , p. 208
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8 p, 435.5 KB |
Soluble urokinase-type plasminogen activator receptor improves early risk stratification in cardiogenic shock
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Hongisto, Mari ;
Lassus, Johan ;
Tarvasmäki, Tuukka ;
Sans-Roselló, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Tolppanen, Heli ;
Kataja, Anu ;
Jäntti, Toni ;
Sabell, Tuija ;
Banaszewski, Marek ;
Silva-Cardoso, Jose ;
Parissis, John ;
Jurkko, Raija ;
Spinar, Jindrich ;
Castrén, Maaret ;
Mebazaa, Alexandre ;
Masip, Josep ;
Harjola, Veli-Pekka ;
Universitat Autònoma de Barcelona
Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker reflecting the level of immune activation. It has been shown to have prognostic value in acute coronary syndrome and heart failure as well as in critical illness. [...]
2022 - 10.1093/ehjacc/zuac096
European Heart Journal. Acute Cardiovascular Care, Vol. 11 (august 2022) , p. 731-738
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12 p, 975.8 KB |
Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock
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Hänninen, Mikko (Minerva Foundation Institute for Medical Research (Finland)) ;
Jäntti, Toni (Helsinki University Hospital (Finlàndia)) ;
Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Segersvärd, Heli (Minerva Foundation Institute for Medical Research (Finland)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Vausort, Mélanie (Luxembourg Institute of Health) ;
Devaux, Yvan (Luxembourg Institute of Health) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Tikkanen, Ilkka (Helsinki University Hospital (Finlàndia)) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Lakkisto, Päivi (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona
Cardiogenic shock (CS) is a life-threatening emergency. New biomarkers are needed in order to detect patients at greater risk of adverse outcome. Our aim was to assess the characteristics of miR-21-5p, miR-122-5p, and miR-320a-3p in CS and evaluate the value of their expression levels in risk prediction. [...]
2020 - 10.3390/ijms21217925
International journal of molecular sciences, Vol. 21 (october 2020)
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15 p, 1.8 MB |
Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock
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Jäntti, Toni (Helsinki University Hospital (Finlàndia)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Pulkki, Kari (Helsinki University Hospital (Finlàndia)) ;
Turkia, Heidi (Helsinki University Hospital (Finlàndia)) ;
Sabell, Tuija (Helsinki University Hospital (Finlàndia)) ;
Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Jurkko, Raija (Helsinki University Hospital (Finlàndia)) ;
Hongisto, Mari (Helsinki University Hospital (Finlàndia)) ;
Kataja, Anu (Helsinki University Hospital (Finlàndia)) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Silva-Cardoso, Jose (University of Porto) ;
Banaszewski, Marek (National Institute of Cardiology, Warsaw, Poland) ;
DiSomma, Salvatore (University of Rome Sapienza) ;
Mebazaa, Alexandre (University Paris Diderot) ;
Haapio, Mikko (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona
Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in cardiogenic shock populations are lacking. [...]
2021 - 10.1186/s13613-021-00814-8
Annals of Intensive Care, Vol. 11 (february 2021)
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10 p, 563.7 KB |
Mortality risk prediction in elderly patients with cardiogenic shock : results from the CardShock study
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Hongisto, Mari (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Sans-Rosello, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Kataja, Anu (Helsinki University Hospital (Finlàndia)) ;
Jäntti, Toni (Helsinki University Hospital (Finlàndia)) ;
Sabell, Tuija (Helsinki University Hospital (Finlàndia)) ;
Lindholm, Matias Greve (Zealand University Hospital) ;
Banaszewski, Marek (National Institute of Cardiology) ;
Silva Cardoso, Jose (University of Porto, São João University Medical Centre) ;
Parissis, John (University General Hospital Attikon (Haidari, Grècia)) ;
Di Somma, Salvatore (Sapienza University of Rome) ;
Carubelli, Valentina (University and Civil Hospital of Brescia) ;
Jurkko, Raija (Helsinki University Hospital (Finlàndia)) ;
Masip, Josep (Hospital de Sant Joan Despí Moisès Broggi) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona
This study aimed to assess the utility of contemporary clinical risk scores and explore the ability of two biomarkers [growth differentiation factor-15 (GDF-15) and soluble ST2 (sST2)] to improve risk prediction in elderly patients with cardiogenic shock. [...]
2021 - 10.1002/ehf2.13224
ESC Heart Failure, Vol. 8 (january 2021) , p. 1398-1407
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6 p, 288.0 KB |
Prognostic impact of angiographic findings, procedural success, and timing of percutaneous coronary intervention in cardiogenic shock
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Sabell, Tuija (Helsinki University Hospital (Finlàndia)) ;
Banaszewski, Marek (Institute of Cardiology) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Nieminen, Markku S. (Helsinki University Hospital (Finlàndia)) ;
Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Jäntti, Toni (Helsinki University Hospital (Finlàndia)) ;
Kataja, Anu (Helsinki University Hospital (Finlàndia)) ;
Hongisto, Mari (Helsinki University Hospital (Finlàndia)) ;
Køber, Lars (University of Copenhagen) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Parissis, John (University General Hospital Attikon (Haidari, Grècia)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Jurkko, Raija (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona
Urgent revascularization is the mainstay of treatment in acute coronary syndrome (ACS) related cardiogenic shock (CS). The aim was to investigate the association of angiographic results with 90-day mortality. [...]
2020 - 10.1002/ehf2.12637
ESC Heart Failure, Vol. 7 (march 2020) , p. 768-773
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5 p, 173.0 KB |
Circulating levels of 423-5p are associated with 90 day mortality in cardiogenic shock
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Jäntti, Toni (Helsinki University Hospital (Finlàndia)) ;
Segersvärd, Heli (Minerva Foundation Institute for Medical Research and University of Helsinki) ;
Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Devaux, Yvan (Luxembourg Institute of Health) ;
Vausort, Mélanie (Luxembourg Institute of Health) ;
Pulkki, Kari (Department of Clinical Chemistry, University of Eastern Finland and Eastern Finland Laboratory Centre (ISLAB)) ;
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tikkanen, Ilkka (Helsinki University Hospital (Finlàndia)) ;
Lakkisto, Päivi (Helsinki University Hospital (Finlàndia)) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. [...]
2018 - 10.1002/ehf2.12377
ESC Heart Failure, Vol. 6 (november 2018) , p. 98-102
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10 p, 989.2 KB |
Adrenomedullin : a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock
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Tolppanen, Heli (Helsinki University Hospital (Finlàndia)) ;
Rivas-Lasarte, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Lassus, Johan (Helsinki University Hospital (Finlàndia)) ;
Sans-Roselló, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Hartmann, Oliver (Sphingotec GmbH, Hennigsdorf, Germany) ;
Lindholm, Matias (Copenhagen University Hospital Rigshospitalet) ;
Arrigo, Mattia (University Hospital Zurich (Suïssa)) ;
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia)) ;
Köber, Lars (Copenhagen University Hospital Rigshospitalet) ;
Thiele, Holger (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Pulkki, Kari (Eastern Finland Laboratory Centre) ;
Spinar, Jindrich (International Clinical Research Centre (ICRC), Brno, Czech Republic) ;
Parissis, John (University General Hospital Attikon (Haidari, Grècia)) ;
Banaszewski, Marek (Intensive Cardiac Therapy Clinic, Institute of Cardiology, Warsaw, Poland) ;
Silva-Cardoso, Jose (Department of Cardiology, CINTESIS, Porto Medical School, São João Hospital Center, University of Porto) ;
Carubelli, Valentina (Division of Cardiology, Department of Medical and Surgical Specialties Radiological Sciences and Public Health, University and Civil Hospital of Brescia) ;
Sionis, Alessandro (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia)) ;
Mebazaa, Alexandre (Université Paris Diderot) ;
Universitat Autònoma de Barcelona
The clinical CardShock risk score, including baseline lactate levels, was recently shown to facilitate risk stratification in patients with cardiogenic shock (CS). As based on baseline parameters, however, it may not reflect the change in mortality risk in response to initial therapies. [...]
2017 - 10.1186/s13613-016-0229-2
Annals of Intensive Care, Vol. 7 (january 2017)
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