Results overview: Found 74 records in 0.02 seconds.
Articles, 63 records found
Books and collections, 1 records found
Research literature, 10 records found
Articles 63 records found  1 - 10nextend  jump to record:
1.
9 p, 2.2 MB Boosting cancer immunotherapies with optical biosensor nanotechnologies / Soler Aznar, Maria (Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
An increasing number of cancer patients have found new hope in the form of recently discovered cell immunotherapies. These novel treatments empower our own immune system to fight and eradicate the malignant tumours, even in metastatic stages. [...]
2019
European Medical Journal Oncology, Vol. 4, Núm. 4 (December 2019) , p. 124-132  
2.
16 p, 3.4 MB How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections : COVID-19 Case / Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ; Cardenosa-Rubio, Maria (Institut Català de Nanociència i Nanotecnologia) ; Astua, Alejandro (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
The global sanitary crisis caused by the emergence of the respiratory virus SARS-CoV-2 and the COVID-19 outbreak has revealed the urgent need for rapid, accurate, and affordable diagnostic tests to broadly and massively monitor the population in order to properly manage and control the spread of the pandemic. [...]
2020 - 10.1021/acssensors.0c01180
ACS Sensors, Vol. 5, Issue 9 (September 2020) , p. 2659-2972  
3.
9 p, 587.2 KB Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers / Portela Otaño, Alejandro (Institut Català de Nanociència i Nanotecnologia) ; Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ; Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ; Medina Escuela, Alfonso (Universidad de Las Palmas de Gran Canaria) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Nanoplasmonic biosensors based on nanogap antenna structures usually demand complex and expensive fabrication processes in order to achieve a good performance and sensitive detection. We here report the fabrication of large-area nanoplasmonic sensor chips based on nanogap antennas by employing a customized, simple and low-cost colloidal lithography process. [...]
2020 - 10.1039/d0tb00307g
Journal of materials chemistry B, Vol. 8, Issue 19 (May 2020) , p. 4310-4317  
4.
32 p, 2.4 MB A compact SPR biosensor device for the rapid and efficient monitoring of gluten-free diet directly in human urine / Peláez Gutiérrez, Enelia Cristina (Institut Català de Nanociència i Nanotecnologia) ; Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ; Domínguez, Remedios (Biomedal S.L) ; Sousa, Carolina (Universidad de Sevilla) ; Cebolla, Angel (Biomedal S.L) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Celiac disease (CD) is a chronic autoimmune disorder induced in genetically susceptible individuals by the ingestion of gluten from wheat, rye, barley, or certain varieties of oats. A careful diet follow-up is necessary to avoid health complications associated with long-term gluten intake by the celiac patients. [...]
2020 - 10.1007/s00216-020-02616-6
Analytical and bioanalytical chemistry, Vol. 412 (April 2020) , p. 6407-6417  
5.
20 p, 1.1 MB Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor / Maldonado, Jesús (Institut Català de Nanociència i Nanotecnologia) ; Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ; Fernández Gavela, Adrián (Institut Català de Nanociència i Nanotecnologia) ; González López, Juan José (Hospital Universitari Vall d'Hebron) ; González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Nosocomial infections are a major concern at the worldwide level. Early and accurate identification of nosocomial pathogens is crucial to provide timely and adequate treatment. A prompt response also prevents the progression of the infection to life-threatening conditions, such as septicemia or generalized bloodstream infection. [...]
2020 - 10.1039/c9an01485c
Analyst, Vol. 145, Issue 2 (January 2020) , p. 497-506  
6.
24 p, 683.3 KB Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing : Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis / Peláez Gutiérrez, Enelia Cristina (Institut Català de Nanociència i Nanotecnologia) ; Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ; Mongui, Álvaro (Corporación CorpoGen) ; Menéndez, M. Carmen (Universidad Autónoma de Madrid) ; Toro, Carlos (La Paz University Hospital) ; Herrera Sandoval, Oscar L. (Universidad Central) ; Robledo, Jaime (Corporación para Investigaciones Biológicas) ; García, María J. (Universidad Autónoma de Madrid) ; Portillo, Patricia del (Corporación CorpoGen) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Advancements that occurred during the last years in the diagnosis of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis infection, have prompted increased survival rates of patients. [...]
2020 - 10.1021/acsinfecdis.9b00502
ACS infectious diseases, Vol. 6, Issue 5 (May 2020) , p. 1110-1120  
7.
11 p, 1.1 MB Array of Microfluidic Beam Resonators for Density and Viscosity Analysis of Liquids / Márquez, Salomón (Institut Català de Nanociència i Nanotecnologia) ; Álvarez, Mar (Institut de Microelectrònica de Barcelona) ; Fariña, David (Institut Català de Nanociència i Nanotecnologia) ; Homs Corbera, Antoni (Institut Català de Nanociència i Nanotecnologia) ; Domínguez Horna, Carlos (Institut de Microelectrònica de Barcelona) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
This paper reports on the design, fabrication, and evaluation of a mass density and viscosity sensor based on an array of polysilicon microbeam resonators integrated with 20 pL fluidic microchannels. [...]
2017 - 10.1109/JMEMS.2017.2709944
Journal of microelectromechanical systems, Vol. 26, Issue 4 (August 2017) , p. 749-757  
8.
Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Escuela, Alfonso M. (Universidad de Las Palmas de Gran Canaria) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteomes by the alternative selection of exonic sequences. Alterations in this mechanism are associated with most cancers, enhancing their proliferation and survival, and can be employed as cancer biomarkers. [...]
2019 - 10.1021/acs.analchem.9b03898
Analytical chemistry, Vol. 91, Issue 23 (December 2019) , p. 15138-15146  
9.
25 p, 1.7 MB Advanced Evanescent-Wave Optical Biosensors for the Detection of Nucleic Acids : An Analytic Perspective / Sánchez Huertas, César (Royal Melbourne Institute of Technology University) ; Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ; Mitchell, Arnan (Royal Melbourne Institute of Technology University) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Evanescent-wave optical biosensors have become an attractive alternative for the screening of nucleic acids in the clinical context. They possess highly sensitive transducers able to perform detection of a wide range of nucleic acid-based biomarkers without the need of any label or marker. [...]
2019 - 10.3389/fchem.2019.00724
Frontiers in chemistry, Vol. 7 (October 2019) , art. 724  
10.
Advances in nanoplasmonic biosensors for clinical applications / Mauriz, Elba (Universidad de León) ; Dey, Priyanka (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Biomarkers are unquestionable biological indicators for diagnosis and therapeutic interventions providing appropriate classification of a wide range of health disorders and risk factors. Nonetheless, the detection and quantification of biomarkers need to be tested with sufficient reliability by robust analytical methods in order to assure clinical performance in health care settings. [...]
2019 - 10.1039/c9an00701f
Analyst, Vol. 144, Issue 24 (December 2019) , p. 7105-7129  

Articles : 63 records found   1 - 10nextend  jump to record:
Books and collections 1 records found  
1.
2 p, 184.0 KB Optimization Study of Bimodal Waveguide Interferometric Biosensors / Grajales García, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Clinical diagnosis of diseases dependant on genetics of patients is still limited due to the lack of quick, precise, cheap and reliable technological tools. Such diagnostic tools would allow the design of personalized treatments for each patient according to its genetic profile. [...]
Munich : OSA Publishing, 2015 (Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference)
European Conference on Lasers and Electro-Optics, June 2015, p. JSII_1a_2  

Research literature 10 records found  
1.
215 p, 7.4 MB Clinical diagnosis and pathogen detection with a novel multiplexed nanophotonic point-of-care biosensor / Fabri Faja, Nuria, autor. ; Lechuga Gómez, Laura M., supervisor acadèmic. ; Estévez Alberola, M. Carmen, supervisor acadèmic. ; Alonso Chamarro, Julián, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Química
El trabajo que recoge esta tesis doctoral se centra en el estudio y aplicación de un nuevo biosensor nanofotónico con configuración de microarray en formato point-of-care para la detección y cuantificación directa y sin marcaje de varios biomarcadores clínicos y microorganismos patógenos. [...]
This Doctoral Thesis focuses on a novel point-of-care device based on a nanophotonic microarray biosensor for the direct and label-free quantification of multiple clinical biomarkers for clinical diagnosis and pathogen detection directly on patient's sample. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
2.
169 p, 5.8 MB Simple and low cost nanostructured plasmonic biosensor for sensitive and multiplexed biodetection / López Muñoz, Gerardo Arturo, autor. ; Lechuga Gómez, Laura M., supervisor acadèmic. ; Estévez Alberola, Mª Carmen, supervisor acadèmic. ; Pellicer Vilà, Eva M. (Eva Maria) supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Física
La creciente demanda de plataformas de análisis que sean fiables y, al mismo tiempo, fáciles de usar y compactas, que requieran un bajo consumo de muestras y proporcionen una alta sensibilidad y una respuesta en tiempo real, ha proporcionado una considerable innovación en el diseño de los biosensores. [...]
The increasing demand for analytical platforms that are reliable and, at the same time, easy to use and compact, that require low sample consumption and provide high sensitivity and real-time response, have provided considerable innovation in the design of the biosensors. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
3.
176 p, 7.2 MB Lab-on-a-chip integration of the bimodal waveguide nanointerferometric biosensor / Grajales García, Daniel, autor. ; Lechuga, Laura M., supervisor acadèmic. ; Sendra Sendra, José Ramón, supervisor acadèmic. ; Jiménez, David, 1970- supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica ; Institut Català de Nanociència i Nanotecnologia (ICN2)
La presente tesis doctoral se centra en la integración del novedoso biosensor nanointerferométrico de guías de onda bimodal (BiMW biosensor) en una plataforma lab-on-chip para la detección temprana de biomarcadores relacionados con el diagnóstico clínico de enfermedades directamente en la muestra del paciente. [...]
This doctoral Thesis focuses on the integration of the novel Bimodal Waveguide Nanointerferometric Biosensor (BiMW) into a Lab-On-a-Chip (LOC) platform which can allow the direct detection of biomarkers for diseases diagnosis directly in the patient's sample. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2018.  
4.
172 p, 3.9 MB Interferometric biosensors for rapid identification of nosocomial infections / Maldonado Vázquez, Jesús Manuel, autor ; Lechuga, Laura M., supervisor acadèmic ; González Guerrero, Ana Bélen, supervisor acadèmic ; Villaverde Corrales, Antonio, supervisor acadèmic (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
Esta tesis doctoral se centra en el desarrollo de un nuevo biosensor óptico como una técnica alternativa para la identificación de infecciones nosocomiales con el fin de determinar el tratamiento más eficaz y reducir el uso inespecífico de fármacos antimicrobianos de amplio espectro. [...]
This doctoral Thesis is focusing on the development of a novel optical biosensor as an alternative technique for the identification of nosocomial infections in a faster way. This new tool will also facilitate the finding of the most effective treatment for each patient, reduce the nonspecific use of broad-spectrum antimicrobial drugs, and facilitate new antibiotic treatments. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2017  
5.
168 p, 7.7 MB Development of integrated plasmomechanical sensors in microfluidic devices for live cell analysis / Solís Tinoco, Verónica Iraís, autor ; Lechuga, Laura M., supervisor acadèmic ; Sepúlveda Martínez, Borja, supervisor acadèmic ; Jiménez Jiménez, David, supervisor acadèmic (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ; Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica
Esta Tesis doctoral se centra en el diseño, estudio y optimización de una metodología controlada para la fabricación de un sensor flexible y plasmo-mecánico integrado con microfluídica, así como en su caracterización óptica y mecánica. [...]
This doctoral Thesis focuses on the design, study, and optimization of the controlled fabrication metodology of a flexible plasmo-mechanical sensor with microfluidics, as well as its optical and mechanical characterization. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
6.
95 p, 4.8 MB Array of microfluidic beam resonators for mass sensing applications : design, fabrication and testing / Marquez Villalobos, Salomón Elieser ; Lechuga Gómez, Laura M., dir. ; Álvarez Sánchez, Mar, dir. ; Jiménez Jiménez, David, dir. (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ; Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica
En la búsqueda de herramientas de diagnóstico más eficientes, los dispositivos biosensores basados en resonadores micro y nanoelectromecánicos han demostrado un gran impacto en este ámbito debido a su alta sensibilidad, tamaño miniaturizado y su rápida respuesta a una interacción. [...]
In the pursuit of more efficient diagnosis tools, micro- and nanomechanical biosensors have shown promising impact due to its high sensitivity, fast interaction and small size. Under this premise, the present Doctoral Thesis has the ultimate objective of integrating a mass sensor based on Micro-Electro-Mechanical Systems (MEMS) resonators into a Lab-on-a-Chip platform for the simultaneous detection of different analytes in real-time. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016
3 documents
7.
217 p, 6.6 MB Nanophotonic biosensors for deciphering cell regulation pathways / Sánchez Huertas, César ; Lechuga, Laura M., dir. ; Villaverde, Antoni ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
La presente Tesis Doctoral se centra en el desarrollo de metodologías analíticas de carácter innovador para el estudio de diferentes rutas de regulación genética. Éstas nuevas técnicas de análisis se presentan como una atractiva alternativa para conseguir un diagnóstico y seguimiento de terapia del cáncer más precisos e informativos. [...]
This Doctoral Thesis focuses on the development of innovative biosensor devices as alternative analytical techniques for the evaluation of different gene regulating pathways in order to obtain a more informative and accurate diagnosis and follow-up therapy of cancer. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
8.
220 p, 7.0 MB Nanoplasmonic biosensors for clinical diagnosis at the point of care / Soler Aznar, Maria ; Estévez Alberola, Maria Carmen, dir. (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M., dir. (Institut Català de Nanociència i Nanotecnologia) ; Arús i Caraltó, Carles, tutor (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Aquesta Tesi Doctoral se centra en el desenvolupament de noves metodologies analítiques en biosensors òptics com a solucions alternatives per a la diagnosi o la monitorització terapèutica de diferents malalties, com ara l'al·lèrgia, la celiaquia o el càncer. [...]
This Doctoral Thesis focuses on the development of novel analytical methodologies in optical biosensors as alternative solutions for diagnosis or therapy monitoring of relevant diseases, such as allergy, celiac disease or cancer. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
9.
175 p, 7.7 MB Estrategias de inmovilización de anticuerpos para la detección directa de hormonas mediante Inmunosensores de Resonancia de Plasmón Superficial / De Juan Franco, Elena ; Lechuga Gómez, Laura M., dir. ; Ordóñez, J. 1952- (Jordi), tutor (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
En este trabajo de tesis se han desarrollado distintas estrategias para la inmovilización controlada de anticuerpos sobre la superficie sensora de dispositivos biosensores de Resonancia de Plasmón Superficial. [...]
This thesis focused on the development of different strategies for the site-directed immobilization of antibodies on the sensor surface of Surface Plasmon Resonance devices. These immunosensors were applied in the determination of the hTSH and hGH hormones, which play a crucial role in the human growth and development. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  
10.
200 p, 10.4 MB Bimodal waveguide interferometer device based on silicon photonics technology for label-free and high sensitive biosensing / González Guerrero, Ana Belén ; Lechuga, Laura M., dir. ; Pascual i Gainza, Jordi tutor (Universitat Autònoma de Barcelona. Departament de Física) ; Universitat Autònoma de Barcelona. Departament de Física
Els dispositius òptics biosensors basats en la detecció d'ona evanescent podrien superar les limitacions dels tests de diagnòstic actuals (que són lents i cars) degut a la possibilitat de realitzar les deteccions a temps reals i fent servir un esquema sense la necessitat de marcatges. [...]
Optical biosensor devices based on evanescent wave detection could overcome the limitations of conventional diagnostic tests (expensive and time-consuming) due to the possibility of carrying out the detection in real-time and using a label-free scheme. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  

See also: similar author names
1 Lechuga, L. M.,
6 Lechuga, Laura M.,
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