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12 p, 4.9 MB |
Rapid and direct quantification of the SARS-CoV-2 virus with an ultrasensitive nanobody-based photonic nanosensor
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Ruiz Vega, Gisela (Institut Català de Nanociència i Nanotecnologia) ;
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Ramirez Priego, Patricia (Institut Català de Nanociència i Nanotecnologia) ;
Pazos, Martalu D. (Institut Català de Nanociència i Nanotecnologia) ;
Noriega, María A. (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología) ;
Margolles, Yago (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología) ;
Francés-Gómez, Clara (Universitat de València. Institut de Biologia Integrativa de Sistemes) ;
Geller, Ron (Universitat de València. Institut de Biologia Integrativa de Sistemes) ;
Matusali, Giulia (Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS) ;
Colavita, Francesca (Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS) ;
Caro, Antonino di (Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS) ;
Casasnovas, José M. (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología) ;
Fernández, Luis Angel (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
The coronavirus (CoV) disease 2019 (COVID-19) is expected to become endemic in the coming years, meaning that the worldwide society shall be prepared to routinely manage the highly contagious respiratory SARS-CoV-2. [...]
2022 - 10.1039/D2SD00082B
Sensors & Diagnostics, Vol. 1, issue 5 (Sep. 2022) , p. 983-993
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48 p, 1.4 MB |
Coating bioactive microcapsules with tannic acid enhances the phenotype of the encapsulated pluripotent stem cells
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Choi, Daheui (Mayo Clinic, Department of Physiology and Biomedical Engineering) ;
Gwon, Kihak (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Hong, Hye Jin (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Baskaran, Harihara (Case Western Reserve University. Department of Chemical and Biomolecular Engineering) ;
Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Gonzalez-Suarez, Alan M. (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Park, Kyungtae (Yonsei University. Department of Chemical and Biomolecular Engineering) ;
De Hoyos-Vega, Jose M. (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia) ;
Hong, Jinkee (Yonsei University. Department of Chemical and Biomolecular Engineerin) ;
Stybayeva, Gulnaz (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Revzin, Alexander (Mayo Clinic. Department of Physiology and Biomedical Engineering)
Human pluripotent stem cells (hPSCs) may be differentiated into any adult cell type and therefore hold incredible promise for cell therapeutics and disease modeling. There is increasing interest in three-dimensional (3D) hPSC culture because of improved differentiation outcomes and potential for scale up. [...]
2022 - 10.1021/acsami.2c06783
ACS applied materials & interfaces, Vol. 14, issue 23 (June 2022) , p. 27274-27286
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7 p, 2.4 MB |
One-step and real-time detection of microRNA-21 in human samples for lung cancer biosensing diagnosis
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Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
García Aparicio, Pablo (Institut Català de Nanociència i Nanotecnologia) ;
Raduly, Lajos-Zsolt (Iuliu Hatieganu University of Medicine and Pharmacy) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Berindan Neagoe, Ioana (Iuliu Hatieganu University of Medicine and Pharmacy) ;
Ferracin, Manuela (Università di Bologna. Dipartimento di Scienze Mediche e Chirurgiche) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
The rapid diagnosis of cancer, especially in its early stages, is crucial for on-time medical treatment and for increasing the patient survival rate. Lung cancer shows the highest mortality rate and the lowest 5-year survival rate due to the late diagnosis in advanced cancer stages. [...]
2022 - 10.1021/acs.analchem.2c02895
Analytical chemistry, Vol. 94, issue 42 (Oct. 2022) , p. 14659-14665
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15 p, 11.2 MB |
Integrated optical bimodal waveguide biosensors : principles and applications
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Torrijos-Morán, Luis (Universitat Politècnica de València. Nanophotonics Technology Center) ;
Diego Lisboa, Bárbara (Institut Català de Nanociència i Nanotecnologia) ;
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia) ;
García-Rupérez, J. (Nanophotonics Technology Center. Universitat Politècnica de València)
Integrated optical biosensors have become one of the most compelling technologies for the achievement of highly sensitive, multianalyte, portable and easy to use point-of-care (POC) devices with tremendous impact in healthcare and environmental protection, among other application fields. [...]
2022 - 10.1016/j.rio.2022.100285
Results in Optics, Vol. 9 (Dec. 2022) , art. 100285
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8 p, 994.1 KB |
Novel sensing algorithm for linear read-out of bimodal waveguide interferometric biosensors
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Bassols-Cornudella, Bernat (Institut Català de Nanociència i Nanotecnologia) ;
Ramirez Priego, Patricia (Institut Català de Nanociència i Nanotecnologia) ;
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Díaz-Luisravelo, Heriberto J (Institut Català de Nanociència i Nanotecnologia) ;
Cardenosa-Rubio, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Biosensors employing photonics integrated circuits, and specifically those that rely on interferometric evanescent wave working principles, have outstanding performances due to the extreme sensitivity exhibited in one-step and direct assay, without the need of amplification. [...]
2022 - 10.1109/JLT.2021.3118103
Journal of Lightwave Technology, Vol. 40, issue 1 (Jan. 2022) , p. 237-244
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15 p, 2.7 MB |
Biochemistry strategies for label-free optical sensor biofunctionalization : advances towards real applicability
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Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Label-free biosensors, and especially those based on optical transducers like plasmonic or silicon photonic systems, have positioned themselves as potential alternatives for rapid and highly sensitive clinical diagnostics, on-site environmental monitoring, and for quality control in foods or other industrial applications, among others. [...]
2021 - 10.1007/s00216-021-03751-4
Analytical and bioanalytical chemistry, Vol. 414, Issue 18 (November 2021) , p. 5071-5085
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10 p, 3.1 MB |
Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology : Implementation and Clinical Validation
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Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Sierra, Miquel (Institut Català de Nanociència i Nanotecnologia) ;
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
González-López, Juanjo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron) ;
Fernandez-Naval, Candela (Hospital Universitari Vall d'Hebron) ;
Bueno, Leticia (Hospital Clínic i Provincial de Barcelona) ;
López-Aladid, Ruben (Hospital Clínic i Provincial de Barcelona) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Barat, Laia (Hospital Clínic i Provincial de Barcelona) ;
Attoumani, Sarah (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Charrel, Rémi (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Coutard, Bruno (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Serological tests are essential for the control and management of COVID-19 pandemic (diagnostics and surveillance, and epidemiological and immunity studies). We introduce a direct serological biosensor assay employing proprietary technology based on plasmonics, which offers rapid (<15 min) identification and quantification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in clinical samples, without signal amplification. [...]
2022 - 10.1021/acs.analchem.1c03850
Analytical chemistry, Vol. 94, Issue 2 (January 2022) , p. 975-984
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