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Articles, 1 records found
Research literature, 1 records found
Articles 1 records found  
15 p, 11.4 MB Neuroprotective drug for nerve trauma revealed using artificial intelligence. / Romeo Guitart, David (Universitat Autónoma de Barcelona. Institut de Neruorciències) ; Forés, Joaquim (Hospital Clínic i Provincial.Unitat del Sistema Nervioso Periférico) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Insitut de Neurociències) ; Valls, Raquel (Anaxomics Biotech.) ; Leiva Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González-Pérez, Francisco (Universitat Autònoma de Barcelona. Institut de Neruociències) ; Navarro, Xavier. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neruociències) ; Petegnief, Valerie (Institut de Recerca Biomèdica de Barcelona(IBB)) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Coma, Mireia (Anaxomics Biotech.) ; Mas, José Manuel (Anaxomics Biotech.) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Here we used a systems biology approach and artifcial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. [...]
2018 - 10.1038/s41598-018-19767-3
Scientific reports, Vol. 8 (2018) , art. 1879  

Research literature 1 records found  
213 p, 12.9 MB Investigation of the role and modulation of autophagy for neuroprotection and nerve regeneration using models of peripheral nerve injury / Leiva Rodríguez, Tatiana, autor. ; Casas Louzao, Catalina, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia.
Lesiones en el nervio periférico causan una disrupción axonal que puede producir una neurodegeneración retrograda. Las neuronas axotomizadas sufren una serie de cambios fenotípicos a nivel molecular y celular, algunos de ellos llamados mecanismos endógenos de neuroprotección, que promueven la supervivencia neuronal. [...]
Severe peripheral nerve injury (PNI) cause axonal disruption and may produce retrograde neurodegeneration. Axotomized neurons undergo a series of phenotypic changes at the molecular and cellular levels, some of them called endogenous mechanisms of neuroprotection, that promote neuronal survival that includes the unfolded protein response (UPR), the heat-shock response, the autophagy pathway, the ubiquitin-proteasome system, chaperone, the endoplasmic reticulum (ER)-associated degradation machinery (ERAD) and the antioxidant defence. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  

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