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28 p, 6.3 MB PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells / Georgilis, Athena (Imperial College London) ; Klotz, Sabrina (Eberhard Karls University Tübingen) ; Hanley, Christopher J. (University of Southampton) ; Herranz, Nicolas (Imperial College London) ; Weirich, Benedikt (German Cancer Research Centre (DKFZ)) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Leote, Ana Carolina (Universidade de Lisboa) ; D'Artista, Luana (Eberhard Karls University Tübingen) ; Gallage, Suchira (German Cancer Research Centre (DKFZ)) ; Seehawer, Marco (Eberhard Karls University Tübingen) ; Carroll, Thomas (Imperial College London) ; Dharmalingam, Gopuraja (Imperial College London) ; Wee, Keng Boon (Bioinformatics Institute) ; Mellone, Marco (University of Southampton) ; Pombo, Joaquim (Imperial College London) ; Heide, Danijela (German Cancer Research Centre (DKFZ)) ; Guccione, Ernesto (Institute of Molecular and Cell Biology (Singapore)) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Barbosa-Morais, Nuno L. (Universidade de Lisboa) ; Heikenwälder, Mathias (German Cancer Research Centre (DKFZ)) ; Thomas, Gareth J. (University of Southampton) ; Zender, Lars (German Cancer Research Center (DKFZ)) ; Gil, Jesús (Imperial College London)
Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. [...]
2018 - 10.1016/j.ccell.2018.06.007
Cancer Cell, Vol. 34 (july 2018) , p. 85-102.e9  

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