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15 p, 1.8 MB Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory / Fá, M. (Columbia University. Department of Pathology and Cell Biology) ; Puzzo, D. (University of Catania. Department of Biomedical and Biotechnological Sciences) ; Piacentini, R. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ; Staniszewski, A. (Columbia University. Department of Pathology) ; Zhang, H. (Columbia University. Department of Pathology) ; Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Li Puma, D. D. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ; Chatterjee, I. (Oligomerix) ; Li, J. (Third Military Medical University. Department of Neurology) ; Saeed, F. (Columbia University. Department of Pathology and Cell Biology) ; Berman, H. L. (Columbia University. Department of Pathology) ; Ripoli, C. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ; Gulisano, W. (University of Catania. Department of Biomedical and Biotechnological Sciences) ; Gonzalez, J. (Rockefeller University. Translational Technology Core Laboratory) ; Tian, H. (Tempe. Department of Chemical Engineering) ; Costa, J. A. (Columbia University. Department of Pathology and Cell Biology) ; Lopez, P. (Oligomerix) ; Davidowitz, E. (Oligomerix) ; Yu, W. H. (Columbia University. Department of Pathology and Cell Biology) ; Haroutunian, V. (The Mount Sinai School of Medicine. Department of Psychiatry) ; Brown, L. M. (Columbia University. Department of Biological Sciences) ; Palmeri, A. (University of Catania. Department of Biomedical and Biotechnological Sciences) ; Sigurdsson, E. M. (NYU Langone Medical Center. Department of Neuroscience and Physiology) ; Duff, K. E. (Columbia University. Department of Pathology and Cell Biology) ; Teich, A. F. (Columbia University. Department of Pathology and Cell Biology) ; Honig, L. S. (Columbia University. Department of Pathology and Cell Biology) ; Sierks, M. (Rockefeller University. Translational Technology Core Laboratory) ; Moe, J. G. (Oligomerix) ; D'Adamio, L. (Einstein College of Medicine. Department of Microbiology and Immunology) ; Grassi, C. (Hospitalization and Health Care) ; Kanaan, N. M. (College of Human Medicine. Department of Translational Science and Molecular Medicine) ; Fraser, P. E. (University of Toronto. Department of Medical Biophysics) ; Arancio, Ottavio (Columbia University. Department of Pathology and Cell Biology) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer's disease (AD). The prevailing hypothesis on the disease etiopathogenesis is that oAβ initiates tau pathology that slowly spreads throughout the medial temporal cortex and neocortices independently of Aβ, eventually leading to memory loss. [...]
2016 - 10.1038/srep19393
Scientific reports, Vol. 6 (January 2016) , art. 19393  

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