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8 p, 2.3 MB |
Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models Are Glucocorticoid Mediated
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Lin, Tzu-Kai (College of Medicine, National Cheng Kung University. Institute of Clinical Medicine) ;
Man, Mao-Qiang (University of California, San Francisco. Dermatology Service) ;
Santiago, Juan-Luis (Hospital General Universitario de Ciudad Real) ;
Scharschmidt, Tiffany C. (University of California, San Francisco. Dermatology Service) ;
Hupe, Melanie (University of California, San Francisco. Dermatology Service) ;
Martin-Ezquerra, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Youm, Jong-Kyung (University of California, San Francisco. Dermatology Service) ;
Zhai, Yongjiao (University of California, San Francisco. Dermatology Service) ;
Trullas, Carles (ISDIN) ;
Feingold, Kenneth R. (University of California, San Francisco. Dermatology Service) ;
Elias, Peter M. (University of California, San Francisco. Dermatology Service) ;
Universitat Autònoma de Barcelona
Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the host, but the current medical paradigm holds that PS exacerbates systemic and cutaneous inflammatory disorders. [...]
2014 -  10.1038/jid.2014.265
The Journal of investigative dermatology, Vol. 134 (08 2014) , p. 2890-2897
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20 p, 1.3 MB |
Basis for enhanced barrier function of pigmented skin
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Man, Mao-Qiang (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Lin, Tzu-Kai (Graduate Institute of Clinical Medicine, National Cheng Kung University Medical College & Department of Dermatology, Tainan, Taiwan) ;
Santiago, Juan Luis (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Celli, Anna (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Zhong, Lily (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Huang, Zhi-Ming (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Roelandt, Truus (Department of Dermatology, Universitair Ziekenhuis Brussel, Brussels, Belgium) ;
Hupe, Melanie (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Sundberg, John P. (Department of Research and Development, The Jackson Laboratory, Bar Harbor, ME) ;
Silva, Kathleen A. (Department of Research and Development, The Jackson Laboratory, Bar Harbor, ME) ;
Crumrine, Debra (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Martin-Ezquerra, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Trullas, Carles (ISDIN, Research & Development, Barcelona, Spain) ;
Sun, Richard (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Wakefield, Joan S. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Wei, Maria L. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Feingold, Kenneth R. (Medical Service, Department of Veterans Affairs Medical Center, and Department of Metabolism, UCSF, San Francisco, CA) ;
Mauro, Theodora M. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Elias, Peter M. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Humans with darkly-pigmented skin display superior permeability barrier function in comparison to humans with lightly-pigmented skin. The reduced pH of the stratum corneum (SC) of darkly-pigmented skin could account for enhanced function, because acidifying lightly-pigmented human SC resets barrier function to darkly-pigmented levels. [...]
2014 - 10.1038/jid.2014.187
The Journal of investigative dermatology, Vol. 134 (april 2014) , p. 2399-2407
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