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1.
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7 p, 914.3 KB |
U-turn speed is a valid and reliable smartphone-based measure of multiple sclerosis-related gait and balance impairment
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Cheng, Wei Yi (F. Hoffmann-La Roche Ltd) ;
Bourke, Alan K. (F. Hoffmann-La Roche Ltd) ;
Lipsmeier, Florian (F. Hoffmann-La Roche Ltd) ;
Bernasconi, Corrado (F. Hoffmann-La Roche Ltd) ;
Belachew, Shibeshih (F. Hoffmann-La Roche Ltd) ;
Gossens, Christian (F. Hoffmann-La Roche Ltd) ;
Graves, Jennifer S. (University of California) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Lindemann, Michael (Baden-Wuerttemberg Cooperative State University) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: People living with multiple sclerosis (MS) experience impairments in gait and mobility, that are not fully captured with manually timed walking tests or rating scales administered during periodic clinical visits. [...]
2021 -  10.1016/j.gaitpost.2020.11.025
Gait and Posture, Vol. 84 (february 2021) , p. 120-126
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2.
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15 p, 1.7 MB |
Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis
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Graves, Jennifer S. (University of California San Diego) ;
Ganzetti, Marco (F. Hoffmann-La Roche Ltd, Basel) ;
Dondelinger, Frank (F. Hoffmann-La Roche Ltd, Basel) ;
Lipsmeier, Florian (F. Hoffmann-La Roche Ltd, Basel) ;
Belachew, Shibeshih (F. Hoffmann-La Roche Ltd, Basel) ;
Bernasconi, Corrado (F. Hoffmann-La Roche Ltd, Basel) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Beek, Johan van (F. Hoffmann-La Roche Ltd, Basel) ;
Baker, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Gossens, Christian (F. Hoffmann-La Roche Ltd, Basel) ;
Lindemann, Michael (F. Hoffmann-La Roche Ltd, Basel) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective To validate the smartphone sensor-based Draw a Shape Test - a part of the Floodlight Proof-of-Concept app for remotely assessing multiple sclerosis-related upper extremity impairment by tracing six different shapes. [...]
2023 - 10.1002/acn3.51705
Annals of Clinical and Translational Neurology, Vol. 10 Núm. 2 (2023) , p. 166-180
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3.
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13 p, 1.1 MB |
Neural correlates of digital measures shown by structural MRI : a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis
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Ganzetti, Marco (F. Hoffmann-La Roche Ltd) ;
Graves, Jennifer (University of California San Diego. Department of Neurosciences) ;
Holm, Sven P. (F. Hoffmann-La Roche Ltd) ;
Dondelinger, Frank (Present Address: Novartis Institutes for Biomedical Research) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Gaetano, Laura (F. Hoffmann-La Roche Ltd) ;
Craveiro, Licinio (F. Hoffmann-La Roche Ltd) ;
Lipsmeier, Florian (F. Hoffmann-La Roche Ltd) ;
Bernasconi, Corrado (F. Hoffmann-La Roche Ltd) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Hauser, Stephen L. (University of California San Francisco. Department of Neurology) ;
Lindemann, Michael (F. Hoffmann-La Roche Ltd) ;
Universitat Autònoma de Barcelona
A study was undertaken to evaluate remote monitoring via smartphone sensor-based tests in people with multiple sclerosis (PwMS). This analysis aimed to explore regional neural correlates of digital measures derived from these tests. [...]
2022 - 10.1007/s00415-022-11494-0
Journal of Neurology, Vol. 270 (december 2022) , p. 1624-1636
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4.
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17 p, 1.5 MB |
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
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Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
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5.
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11 p, 1.5 MB |
A smartphone sensor-based digital outcome assessment of multiple sclerosis
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Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Graves, Jennifer (University of California San Diego) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Mulero, P. (Hospital Universitari Vall d'Hebron) ;
Julian, Laura (Genentech (Estats Units d'Amèrica)) ;
Baker, Michael (F. Hoffmann-La Roche (Suïssa)) ;
Schadrack, Jan (F. Hoffmann-La Roche (Suïssa)) ;
Gossens, Christian (F. Hoffmann-La Roche (Suïssa)) ;
Ganzetti, Marco (F. Hoffmann-La Roche (Suïssa)) ;
Scotland, Alf (F. Hoffmann-La Roche (Suïssa)) ;
Lipsmeier, Florian (F. Hoffmann-La Roche (Suïssa)) ;
van Beek, Johan (F. Hoffmann-La Roche (Suïssa)) ;
Bernasconi, Corrado (F. Hoffmann-La Roche (Suïssa)) ;
Belachew, Shibeshih (F. Hoffmann-La Roche (Suïssa)) ;
Lindemann, Michael (F. Hoffmann-La Roche (Suïssa)) ;
Hauser, Stephen L. (University of California)
Sensor-based monitoring tools fill a critical gap in multiple sclerosis (MS) research and clinical care. The aim of this study is to assess performance characteristics of the Floodlight Proof-of-Concept (PoC) app. [...]
2021 - 10.1177/13524585211028561
Multiple sclerosis, Vol. 28 (july 2021) , p. 654-664
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None, 25.3 KB |
Correction : Adherence and Satisfaction of Smartphone- and Smartwatch-Based Remote Active Testing and Passive Monitoring in People With Multiple Sclerosis: Nonrandomized Interventional Feasibility Study
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Midaglia, Luciana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mulero, P. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (University of Toronto) ;
Graves, Jennifer (University of California) ;
Hauser, Stephen L. (University of California) ;
Julian, Laura (Genentech Inc) ;
Baker, Michael (F Hoffmann-La Roche) ;
Schadrack, Jan ;
Gossens, Christian (F. Hoffmann-La Roche Ltd, Base) ;
Scotland, Alf (F Hoffmann-La Roche) ;
Lipsmeier, Florian (F Hoffmann-La Roche) ;
van Beek, Johan (F Hoffmann-La Roche) ;
Bernasconi, Corrado (F Hoffmann-La Roche) ;
Belachew, Shibeshih (F Hoffmann-La Roche) ;
Lindemann, Michael (Baden-Wuerttemberg Cooperative State University)
2019 - 10.2196/16287
Journal of medical Internet research, Vol. 21 (october 2019)
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7.
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15 p, 948.8 KB |
Adherence and satisfaction of smartphone- And smartwatch-based remote active testing and passive monitoring in people with multiple sclerosis : Nonrandomized interventional feasibility study
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Midaglia, Luciana. (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mulero, P. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (University of Toronto) ;
Graves, Jennifer (University of California, San Diego. Department of Neurology) ;
Hauser, Stephen L. (Department of Neurology. University of California) ;
Julian, Laura (Genentech Inc) ;
Baker, Michael (F Hoffmann-La Roche Ltd) ;
Schadrack, Jan (F Hoffmann-La Roche Ltd) ;
Gossens, Christian (F Hoffmann-La Roche Ltd) ;
Scotland, Alf (F Hoffmann-La Roche Ltd) ;
Lipsmeier, Florian (F Hoffmann-La Roche Ltd) ;
Van Beek, Johan (F Hoffmann-La Roche Ltd) ;
Bernasconi, Corrado (F Hoffmann-La Roche Ltd) ;
Belachew, Shibeshih (F Hoffmann-La Roche Ltd) ;
Lindemann, Michael (Department of Economics. Baden-Wuerttemberg Cooperative State University)
Background: Current clinical assessments of people with multiple sclerosis are episodic and may miss critical features of functional fluctuations between visits. Objective: The goal of the research was to assess the feasibility of remote active testing and passive monitoring using smartphones and smartwatch technology in people with multiple sclerosis with respect to adherence and satisfaction with the FLOODLIGHT test battery. [...]
2019 - 10.2196/14863
Journal of medical Internet research, Vol. 21 Núm. 8 (2019) , p. e14863
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