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Artículos, Encontrados 38 registros
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Artículos Encontrados 38 registros  1 - 10siguientefinal  ir al registro:
1.
13 p, 610.0 KB White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers / van Waalwijk van Doorn, Linda J.C. ; Ghafoorian, Mohsen ; van Leijsen, Esther M.C. ; Claassen, Jurgen A.H.R. ; Arighi, Andrea ; Bozzali, Marco ; Cannas, Jorge ; Cavedo, Enrica ; Eusebi, Paolo ; Farotti, Lucia ; Fenoglio, Chiara ; Fortea, Juan Institut d'Investigació Biomèdica Sant Pau ; Frisoni, Giovanni B. ; Galimberti, Daniela ; Greco, Viviana ; Herukka, Sanna-Kaisa ; Liu, Yawu ; Lleó, Alberto Institut d'Investigació Biomèdica Sant Pau ; de Mendonça, Alexandre ; Nobili, Flavio M. ; Parnetti, Lucilla ; Picco, Agnese ; Pikkarainen, Maria ; Salvadori, Nicola ; Scarpini, Elio ; Soininen, Hilkka ; Tarducci, Roberto ; Urbani, Andrea ; Vilaplana, Eduard Institut d'Investigació Biomèdica Sant Pau ; Meulenbroek, Olga ; Platel, Bram ; Verbeek, Marcel M. ; Kuiperij, H. Bea ; Universitat Autònoma de Barcelona
The cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of Alzheimer's disease (AD). However, CSF biomarker levels can be affected by confounding factors. [...]
2021 - 10.3233/JAD-200496
Journal of Alzheimer's disease, Vol. 79 (january 2021) , p. 163-175  
2.
15 p, 570.6 KB C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts / Costa, Beatrice ; Manzoni, Claudia ; Bernal-Quiros, Manuel ; Kia, Demis A. ; Aguilar, Miquel ; Alvarez, Ignacio ; Alvarez, Victoria ; Andreassen, Ole ; Anfossi, Maria ; Bagnoli, Silvia ; Benussi, Luisa ; Bernardi, Livia ; Binetti, Giuliano ; Blackburn, Daniel ; Boada, Mercè ; Borroni, Barbara ; Bowns, Lucy ; Bråthen, Geir ; Bruni, Amalia C. ; Chiang, Huei-Hsin ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Colville, Shuna ; Conidi, Maria E. ; Cope, Tom E. ; Cruchaga, Carlos ; Cupidi, Chiara ; Di Battista, Maria Elena ; Diehl-Schmid, Janine ; Diez-Fairen, Monica ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Durante, Elisabetta ; Flisar, Dušan ; Frangipane, Francesca ; Galimberti, Daniela ; Gallo, Maura ; Gallucci, Maurizio ; Ghidoni, Roberta ; Graff, Caroline ; Grafman, Jordan H. ; Grossman, Murray ; Hardy, John ; Hernández, Isabel ; Holloway, Guy J.T. ; Huey, Edward D. ; Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Karydas, Anna ; Khoshnood, Behzad ; Kramberger, Milica G. ; Kristiansen, Mark ; Lewis, Patrick A. ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Madhan, Gaganjit K. ; Maletta, Raffaele ; Maver, Aleš ; Menendez-Gonzalez, Manuel ; Milan, Graziella ; Miller, Bruce ; Mol, Merel O. ; Momeni, Parastoo ; Moreno-Grau, Sonia ; Morris, Chris M. ; Nacmias, Benedetta ; Nilsson, Christer ; Novelli, Valeria ; Öijerstedt, Linn ; Padovani, Alessandro ; Pal, Suvankar ; Panchbhaya, Yasmin ; Pastor, Pau ; Peterlin, Borut ; Piaceri, Irene ; Pickering-Brown, Stuart ; Pijnenburg, Yolande A.L. ; Puca, Annibale A. ; Rainero, Innocenzo ; Rendina, Antonella ; Richardson, Anna M.T. ; Rogaeva, Ekaterina ; Rogelj, Boris ; Rollinson, Sara ; Rossi, Giacomina ; Rossmeier, Carola ; Rowe, James B. ; Rubino, Elisa ; Ruiz, Agustín ; Sanchez-Valle, Raquel ; Sando, Sigrid B. ; Santillo, Alexander F. ; Saxon, Jennifer ; Scarpini, Elio ; Serpente, Maria ; Smirne, Nicoletta ; Sorbi, Sandro ; Suh, EunRan ; Tagliavini, Fabrizio ; Thompson, Jennifer C. ; Trojanowski, John Q. ; Van Deerlin, Vivianna M. ; Van der Zee, Julie ; Van Broeckhoven, Christine ; van Rooij, Jeroen ; Van Swieten, John C. ; Veronesi, Arianna ; Vitale, Emilia ; Waldö, Maria L. ; Woodward, Cathy ; Yokoyama, Jennifer ; Escott-Price, Valentina ; Polke, James M. ; Ferrari, Raffaele ; Universitat Autònoma de Barcelona
We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases. [...]
2020 - 10.1212/WNL.0000000000010914
Neurology, Vol. 95 (december 2020) , p. e3288-e3302  
3.
16 p, 903.0 KB Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology / Shi, Liu (University of Oxford) ; Winchester, Laura M. (University of Oxford) ; Liu, Benjamine Y. (University of Oxford) ; Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ribe, Elena M. (University of Oxford) ; Westwood, Sarah (University of Oxford) ; Baird, Alison L. (University of Oxford) ; Buckley, Noel J. (University of Oxford) ; Hong, Shengjun (University of Lübeck) ; Dobricic, Valerija (University of Lübeck) ; Kilpert, Fabian (University of Lübeck) ; Franke, Andre (Christian-Albrechts-University of Kiel) ; Kiddle, Steven (King's College London) ; Sattlecker, Martina (King's College London) ; Dobson, Richard (University College London) ; Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ; Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ashton, Nicholas J. (University of Gothenburg) ; Morgan, Angharad R. (Cardiff University) ; Bos, Isabelle (VU University Medical Center) ; Vos, Stephanie J.B. (Maastricht University) ; ten Kate, Mara (VU University Medical Center) ; Scheltens, Philip (VU University Medical Center) ; Vandenberghe, Rik (University Hospital Leuven) ; Gabel, Silvy (Laboratory for Cognitive Neurology) ; Meersmans, Karen (Laboratory for Cognitive Neurology) ; Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ; De Roeck, Ellen E. (University of Antwerp) ; Sleegers, Kristel (Center for Molecular Neurology) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ; Bordet, Régis (University of Lille) ; Molinuevo, José L. (Barcelonaβeta Brain Research Center (BBRC)) ; Rami, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ; Wallin, Anders (Sahlgrenska University Hospital) ; Kettunen, Petronella (University of Oxford) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Verhey, Frans (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (University of Geneva) ; Peyratout, Gwendoline (University Hospital of Lausanne) ; Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ; Tainta, Mikel (Organización Sanitaria Integrada Goierri) ; Johannsen, Peter (Copenhagen University Hospital) ; Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ; Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ; Frölich, Lutz (University of Heidelberg) ; Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ; Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ; Blennow, Kaj (Sahlgrenska University Hospital) ; Rasmussen, Katrine Laura (University of Copenhagen) ; Nordestgaard, Børge Grønne (Copenhagen University Hospital) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Nielsen, Sune Fallgaard (Copenhagen University Hospital) ; Soininen, Hilkka (University of Eastern Finland) ; Vellas, Bruno (Univeriste Paul Sabatier) ; Kloszewska, Iwona (Medical University of Lodz) ; Mecocci, Patrizia (University of Perugia) ; Zetterberg, Henrik (UCL Institute of Neurology) ; Morgan, B. Paul (Cardiff University) ; Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ; Visser, Pieter Jelle (Karolinska Institutet) ; Bertram, Lars (University of Oslo) ; Nevado-Holgado, Alejo (University of Oxford) ; Lovestone, Simon (University of Oxford) ; Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368  
4.
14 p, 1.2 MB Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration / Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Falgàs, Neus (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Friedberg, Adit (University of California. Department of Neurology) ; Castro-Suárez, Sheila (University of California. Department of Neurology) ; Keret, Ophir (University of California. Department of Neurology) ; Rogers, Nicole (University of California. Department of Neurology) ; Oz, Didem (University of California. Department of Neurology) ; Nigro, Salvatore (Magna Graecia University (Catanzaro, Itàlia). Neuroscience Centre) ; Quattrone, Andrea (Magna Graecia University (Catanzaro, Itàlia). Institute of Neurology) ; Quattrone, Aldo (Institute of Molecular Bioimaging and Physiology (Catanzaro, Itàlia)) ; Wolf, Amy (University of California. Department of Neurology) ; Younes, Kyan (University of California. Department of Neurology) ; Santos-Santos, Miguel (Institut d'Investigació Biomèdica Sant Pau) ; Borrego-Écija, Sergi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cobigo, Yann (University of California. Department of Neurology) ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Lladó, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Grinberg, Lea T. (University of California. Department of Neurology) ; Spina, Salvatore (University of California. Department of Neurology) ; Kramer, Joel H. (University of California. Department of Neurology) ; Rabinovici, Gil D. (University of California. Department of Neurology) ; Boxer, Adam (University of California. Department of Neurology) ; Gorno Tempini, Maria Luisa (University of California. Department of Neurology) ; Miller, Bruce L. (University of California. Department of Neurology) ; Seeley, William W. (University of California. Department of Neurology) ; Rosen, Howard J. (University of California. Department of Neurology) ; Perry, David C. (University of California. Department of Neurology) ; Universitat Autònoma de Barcelona
Can widely available measures of atrophy on magnetic resonance imaging increase diagnostic certainty of underlying frontotemporal lobar degeneration (FTLD) and estimate clinical deterioration in the behavioral variant of frontotemporal dementia (bvFTD)? This diagnostic/prognostic study investigated the clinical utility of 5 validated visual atrophy scales (VAS) and the Magnetic Resonance Parkinsonism Index. [...]
2021 - 10.1001/jamanetworkopen.2021.1290
JAMA network open, Vol. 4 (march 2021)  
5.
17 p, 1.3 MB Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics / Tijms, Betty M (Vrije Universiteit Amsterdam) ; Gobom, Johan (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg) ; Reus, Lianne (Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam) ; Jansen, Iris (Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam) ; Hong, Shengjun (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck) ; Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck) ; Kilpert, Fabian (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck) ; ten Kate, Mara (Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam) ; Barkhof, Frederik (Institutes of Neurology and Healthcare Engineering, UCL London) ; Tsolaki, Magda (1st Department of Neurology, AHEPA University Hospital, Makedonia) ; Verhey, Frans R J (Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University) ; Popp, Julius (Geriatric Psychiatry, Department of Psychiatry, Geneva University Hospital) ; Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ; Vandenberghe, Rik (Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Molinuevo, José Luís (Hospital Clínic i Provincial de Barcelona) ; Engelborghs, Sebastiaan (Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB)) ; Bertram, Lars (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck) ; Lovestone, Simon (Janssen R&D) ; Streffer, Johannes (UCB Biopharma SPRL) ; Vos, Stephanie (Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University) ; Bos, Isabelle (Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University) ; Blennow, Kaj (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg) ; Scheltens, Philip (Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam) ; Teunissen, Charlotte E (Neurochemistry laboratory, Department of Clinical Chemistry, Amsterdam UMC - location VUmc, Amsterdam Neuroscience) ; Zetterberg, Henrik (UK Dementia Research Institute at UCL) ; Visser, Pieter Jelle (Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet) ; Universitat Autònoma de Barcelona
Using CSF proteomics, Tijms et al. identify three Alzheimer's disease subtypes that show: 1) hyperplasticity and increased BACE1 levels; 2) innate immune activation; and 3) blood-brain barrier dysfunction with low BACE1 levels. [...]
2020 - 10.1093/brain/awaa325
Brain, Vol. 143 (november 2020) , p. 3776-3792  
6.
9 p, 2.2 MB Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly / Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Pané, Adriana (Hospital Clínic i Provincial de Barcelona) ; Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ; Montal, Víctor (Institut d'Investigació Biomèdica Sant Pau) ; Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ; Videla, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Ibarzabal, Ainitze (Hospital Clínic i Provincial de Barcelona) ; Casajoana, Anna (Hospital Universitari de Bellvitge) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ; Altuna, Miren (Institut d'Investigació Biomèdica Sant Pau) ; de Hollanda, Ana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Vidal, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ortega, Emilio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Osorio, Ricardo (New York University School of Medicine) ; Convit, Antonio (New York University School of Medicine) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Jiménez, Amanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Universitat Autònoma de Barcelona
Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. [...]
2020 - 10.1002/dad2.12052
Alzheimer's & dementia, Vol. 12 (july 2020)  
7.
13 p, 722.8 KB A C6orf10 / LOC101929163 locus is associated with age of onset in C9orf72 carriers / Zhang, Ming (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Ferrari, Raffaele (Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK) ; Tartaglia, Maria Carmela (Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada) ; Keith, Julia (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Surace, Ezequiel I (Laboratorio de Biología Molecular, Departamento de Neuropatología, Instituto de Investigaciones Neurológicas Dr. Raúl Carrea (FLENI), Buenos Aires, Argentina) ; Wolf, Uri (University of Toronto. Department of Psychiatry) ; Sato, Christine (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Grinberg, Mark (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Liang, Yan (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Xi, Zhengrui (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Dupont, Kyle (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; McGoldrick, Philip (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Weichert, Anna (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; McKeever, Paul M (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Schneider, Raphael (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; McCorkindale, Michael D (Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK) ; Manzoni, Claudia (School of Pharmacy, University of Reading, Whiteknights, Reading, UK) ; Rademakers, Rosa (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ; Graff-Radford, Neill R (Department of Neurology, Mayo Clinic, Jacksonville, FL, USA) ; Dickson, Dennis W (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ; Parisi, Joseph E (Department of Laboratory Medicine and Pathology and Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Boeve, Bradley F (Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Petersen, Ronald C (Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Miller, Bruce L (Department of Neurology, University of California San Francisco Memory and Aging Center, San Francisco, CA, USA) ; Seeley, William W (Department of Neurology and Department of Pathology, University of California San Francisco Memory and Aging Center, San Francisco, CA, USA) ; van Swieten, John C (Department of Neurology, Erasmus MC, Rotterdam, The Netherlands) ; van Rooij, Jeroen (Department of Neurology, Erasmus MC, Rotterdam, The Netherlands) ; Pijnenburg, Yolande (Amsterdam UMC. University Medical Center) ; van der Zee, Julie (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Van Broeckhoven, Christine (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Le Ber, Isabelle (Reference Center for Rare and Young Dementias, Institute of Memory and Alzheimer's Disease (IM2A), Department of Neurology, Hopital Pitié-Salpêtrière, Paris, France) ; Van Deerlin, Vivianna (Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) ; Suh, EunRan (Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) ; Rohrer, Jonathan D (Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK) ; Mead, Simon (MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK) ; Graff, Caroline (Genetics Unit, Theme Aging, Karolinska University Hospital, Stockholm, Sweden) ; Öijerstedt, Linn (Genetics Unit, Theme Aging, Karolinska University Hospital, Stockholm, Sweden) ; Pickering-Brown, Stuart (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, University of Manchester, UK) ; Rollinson, Sara (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, University of Manchester, UK) ; Rossi, Giacomina (Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy) ; Tagliavini, Fabrizio (Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy) ; Brooks, William S (Neuroscience Research Australia and Prince of Wales Clinical School, University of New South Wales, Sydney, Australia) ; Dobson-Stone, Carol (School of Medical Sciences, University of New South Wales, Sydney, Australia) ; Halliday, Glenda M (Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia) ; Hodges, John R (Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia) ; Piguet, Olivier (School of Psychology and Brain and Mind Centre, University of Sydney, Sydney, Australia) ; Binetti, Giuliano (MAC Memory Center, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Benussi, Luisa (Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Ghidoni, Roberta (Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Nacmias, Benedetta (Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy) ; Sorbi, Sandro (IRCCS Don Gnocchi, Florence, Italy) ; Bruni, Amalia C (Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro, Italy) ; Galimberti, Daniela (Neurodegenerative Disease Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Scarpini, Elio (Neurodegenerative Disease Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Rainero, Innocenzo (Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy) ; Rubino, Elisa (Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ruiz, Agustin (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Pastor, Pau (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Diez-Fairen, Monica (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Borroni, Barbara (Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy) ; Pasquier, Florence (National Reference Center for Young Onset Dementia, Neurology Department, Centre Hospitalier Régional Universitaire de Lille, University Hospital, Inserm U1171, DistAlz, Lille, France) ; Deramecourt, Vincent (National Reference Center for Young Onset Dementia, Neurology Department, Centre Hospitalier Régional Universitaire de Lille, University Hospital, Inserm U1171, DistAlz, Lille, France) ; Lebouvier, Thibaud (National Reference Center for Young Onset Dementia, Neurology Department, Centre Hospitalier Régional Universitaire de Lille, University Hospital, Inserm U1171, DistAlz, Lille, France) ; Perneczky, Robert (Imperial College London. School of Public Health) ; Diehl-Schmid, Janine (Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany) ; Grafman, Jordan (Department of Psychology, Weinberg College of Arts and Sciences Northwestern University Chicago, IL, USA) ; Huey, Edward D (The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA) ; Mayeux, Richard (The Gertrude H. Sergievsky Center, The Departments of Neurology, Psychiatry, Epidemiology, School of Public Health, Columbia University, New York, NY, USA) ; Nalls, Michael A (Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA) ; Hernandez, Dena (Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA) ; Singleton, Andrew (Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA) ; Momeni, Parastoo (Rona Holdings, Silicon Valley, CA, USA) ; Zeng, Zhen (Merck & Co., Inc, Kenilworth, NJ, USA) ; Hardy, John (Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK) ; Robertson, Janice (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Zinman, Lorne (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Rogaeva, Ekaterina (Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada)
Discovery of disease age-of-onset modifiers is important for clinical trials and drug design. Zhang et al. perform a genome-wide analysis of epigenetic functional polymorphisms and identify an association between the C6orf10/LOC101929163 locus and age of FTD/ALS onset. [...]
2018 - 10.1093/brain/awy238
Brain, Vol. 141 (september 2018) , p. 2895-2907  
8.
12 p, 2.1 MB Challenges associated with biomarker-based classification systems for Alzheimer's disease / Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ; Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Dickerson, Bradford C. (Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; de Leon, Mony J. (Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY, USA) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
We aimed to evaluate the consistency of the A/T/N classification system. We included healthy controls, mild cognitive impairment, and dementia patients from Alzheimer's disease Neuroimaging Initiative. [...]
2018 - 10.1016/j.dadm.2018.03.004
Alzheimer's & dementia, Vol. 10 (april 2018) , p. 346-357  
9.
5 p, 396.1 KB Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia / Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ; Stantonyonge, Nicole (Institut d'Investigació Biomèdica Sant Pau) ; Martínez-Horta, Saül (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Muñoz, Laia (Institut d'Investigació Biomèdica Sant Pau) ; Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ; Marín-Lahoz, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Gómez Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ; Chico, Ana (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Impaired awareness of hypoglycemia (IAH) is a common complication in patients with type-1 diabetes (T1D). IAH is a major risk factor for severe hypoglycemic events, leading to adverse clinical consequences and cerebral damage. [...]
2020 - 10.1136/bmjdrc-2020-001516
BMJ open diabetes research and care, Vol. 8 (july 2020)  
10.
10 p, 1.5 MB Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome : a cross-sectional study / Fortea, Juan (Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain) ; Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ; Carmona-Iragui, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Benejam, Bessy (Institut d'Investigació Biomèdica Sant Pau) ; Videla, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Fernández, Susana (Fundació Catalana Síndrome de Down) ; Altuna, Miren (Institut d'Investigació Biomèdica Sant Pau) ; Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Montal, Víctor (Institut d'Investigació Biomèdica Sant Pau) ; Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ; Giménez, Sandra (Institut d'Investigació Biomèdica Sant Pau) ; González-Ortiz, Sofía (Parc de Salut Mar (Barcelona, Catalunya)) ; Muñoz, Laia (Institut d'Investigació Biomèdica Sant Pau) ; Estellés, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ; Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ; Wilson, Liam Reese (Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, Douglas House, University of Cambridge, Cambridge, UK) ; Annus, Tiina (Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, Douglas House, University of Cambridge, Cambridge, UK) ; Osorio, Ricardo S (Center for Sleep and Brain Health, Department of Psychiatry, New York University Langone Health, New York, NY, USA) ; Videla, Sebastián (Institut d'Investigació Biomèdica de Bellvitge) ; Lehmann, Sylvain (Institute for Regenerative Medicine & Biotherapy, Université de Montpellier, INSERM, Centre Hospitalier Universitaire de Montpellier, (LBPC-PPC), Montpellier, France) ; Holland, Anthony J (Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, Douglas House, University of Cambridge, Cambridge, UK) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Clarimón, Jordi (Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain) ; Zaman, Shahid H (Cambridgeshire & Peterborough NHS Foundation Trust, Fulbourn Hospital, Elizabeth House, Cambridge, UK) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Alzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. [...]
2020 - 10.1016/S0140-6736(20)30689-9
Lancet (London, England), Vol. 395 (june 2020) , p. 1988-1997  

Artículos : Encontrados 38 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 9 registros  
1.
307 p, 16.1 MB Multimodal biomarkers studies in the continuum dementia with lewy bodies - alzheimer's disease / Morenas Rodríguez, Estrella ; Lleó Bisa, Alberto, dir. ; Fortea Ormaechea, Juan, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
La demència amb cossos de Lewy (DCLw) es caracteritza per la seva heterogeneïtat. En aquesta tesi, el meu objectiu és investigar aquesta heterogeneïtat a través de l'anàlisi dels diferents subtipus clínics basats tant en les característiques de presentació predominants en la fase prodròmica de la malaltia com en la diversitat dels trastorns de la son presents, centrant-me en el trastorn del comportament de la son REM (TCSR). [...]
Una de las características principales de la demencia con cuerpos de Lewy (DCLw) es su heterogeneidad. En esta tesis, mi objetivo es investigar esta heterogeneidad a través del análisis de los diferentes subtipos clínicos basados tanto en las características predominantes durante la fase prodrómica de la enfermedad como en la diversidad de los trastornos del sueño presentes en la enfermedad, centrándome en el trastorno del comportamiento del sueño REM (TCSR). [...]
Dementia with Lewy bodies (DLB) is characterized by its heterogeneity. In this thesis, I aim to investigate this clinical heterogeneity through the analysis of the different clinical subtypes based both on the predominant presentation features at the prodromal phase of the disease and by the assessment of sleep disorders, focusing on REM sleep behaviour disorder (RBD). [...]

2020  
2.
161 p, 4.2 MB Assessing the role of copy number variations, mitochondrial DNA and microRNAs in neurodegenerative disorders / Cervera Carles, Laura ; Clarimón Echavarria, Jordi, dir. ; Lleó Bisa, Alberto, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
Les malalties neurodegeneratives són patologies complexes i progressives que afecten milions de persones a tot el món. Entre d'altres, la malaltia d'Alzheimer (MA), la malaltia de Parkinson (MP) i la demència frontotemporal (DFT) són les tres condicions més prevalents. [...]
Neurodegenerative diseases are complex and progressive disorders that affect millions of people worldwide. Among them, Alzheimer's disease (AD), Parkinson's disease (PD) and frontotemporal dementia (FTD) are three of the most prevalent. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
3.
191 p, 4.1 MB Pathophysiological and structural underpinnings of frontotemporal lobar degeneration : a multimodal biomarker study / Illán Gala, Ignacio ; Lleó Bisa, Alberto, dir. ; Fortea Ormaechea, Juan, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
La degeneración Lobular Frontotemporal (DLFT) es una constructo neuropatológico heterogéneo que incluye diferentes entidades neuropatológicas caracterizadas por una neurodegeneración prominente de los lóbulos frontales y temporales. [...]
Frontotemporal lobar degeneration (FTLD), is a heterogenic pathological construct encompassing multiple neuropathological conditions primarily affecting the frontal and temporal lobes. Although multiple clinical syndromes predict the neuropathological diagnosis of FTLD, clinical-pathological correlations are far from being perfect. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
4.
209 p, 3.4 MB A Biphasic model for cortical structural changes in preclinical AD : a multimodal MRI, CSF and PET study / Vilaplana Martínez, Eduard ; Lleó Bisa, Alberto, dir. ; Fortea Ormaechea, Juan, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
La enfermedad de Alzheimer (EA) se caracteriza neuropatológicamente por la presencia de depósitos extracelulares de ß-amiloide (Aß) y ovillos neurofibrilares intracelulares (proteína tau fosforilada, p-tau) así como fenómenos inflamatorios. [...]
The Alzheimer's disease (AD) neuropathological hallmarks are the presence of extracellular amyloid ß (Aß) deposition and intracellular neurofibrillary tangles (hyperphosphorilated tau protein) as well as inflammation phenomena. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
5.
126 p, 2.6 MB Sporadic cerebral amyloid angiopathy, beyond lobar intracerebral hemorrhage : multimodal biomarker studies of atypical presentations / Carmona Iragui, María ; Blesa González, Rafael, dir. ; Lleó Bisa, Alberto, dir. ; Fortea Ormaechea, Juan, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
La angiopatía amiloide cerebral (C17) se define por el depósito de proteína β-amiloide en las capas media y adventicia de arterias y capilares leptomeníngeos y corticales. Es una causa importante de hemorragia intracerebral lobar, episodios neurológicos focales transitorios y contribuye significativamente al deterioro cognitivo y a la demencia en los ancianos. [...]
La angiopatía amiloide cerebral (CAA) se define por el depósito de proteína β-amiloide en las capas media y adventicia de arterias y capilares leptomeníngeos y corticales. Es una causa importante de hemorragia intracerebral lobar, episodios neurológicos focales transitorios y contribuye significativamente al deterioro cognitivo y a la demencia en los ancianos. [...]
Cerebral Amyloid Angiopathy (CAA) is defined by β-amyloid protein deposition in the media and adventitia of leptomeningeal and cortical small arteries and capillaries. CAA is a major cause of lobar intracerebral hemorrhage (ICH), transient focal neurological episodes, and an important contributor to age-related cognitive decline and dementia in the elderly. [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2017.  
6.
146 p, 3.4 MB Validación en tejido cerebral humano de [F-18]-AV-1451 (T807), un nuevo marcador de la proteína TAU-PHF para tomografía por emisión de positrones / Marquié Sayagués, Marta ; Gómez-Isla, Teresa, dir. (Institut d'Investigació Biomèdica Sant Pau) ; Lleó Bisa, Alberto, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Blesa Gonzàlez, Rafael, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Escartín Siquier, Antonio E., dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona. Departament de Medicina
[F-18]-AV-1451 es un nuevo trazador para la detección de patología tau en vida del sujeto mediante tomografía por emisión de positrones (PET). [F-18]-AV-1451 fue originalmente creado para detectar tau en forma de filamentos de hélices pareadas (PHF) que conforman los ovillos neurofibrilares (ONF), una de las lesiones características de la Enfermedad de Alzheimer (EA). [...]
[F-18]-AV-1451 is a novel tracer for the in vivo detection of tau pathology using emission positron tomography (PET). [F-18]-AV-1451 was originally raised against paired helical filament (PHF)-tau, which if found in neurofibrillary tangles (NFTs), one of the characteristic lesions in Alzheimer's disease (AD). [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
7.
185 p, 1.5 MB Degeneració lobular frontotemporal: estudi clínic, neuropatològic i de biomarcadors / Suárez Calvet, Marc ; Lleó Bisa, Alberto, dir. ; Blesa González, Rafael, dir. ; Illa Sendra, Isabel, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La present tesi té com a objectiu estudiar des de diferents punts de vista la degeneració lobular frontotemporal (FTLD), una malaltia neurodegenerativa que es caracteritza per la pèrdua neuronal focal en els lòbuls frontals i temporals. [...]
The aim of the present thesis is to study frontotemporal lobar degeneration (FTLD), a neurodegenerative disease characterised by a focal neural loss in the frontal and the temporal lobes, from different perspectives. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
8.
179 p, 3.9 MB Cerebrospinal fluid biomarkers for the study of the pathophysiological pathways in Alzheimer's disease / Alcolea, Daniel ; Lleó Bisa, Alberto, dir. ; Blesa González, Rafael ; Universitat Autònoma de Barcelona. Departament de Medicina
Esta tesis profundiza en el conocimiento de las enfermedades neurodegenerativas y, concretamente, en la enfermedad de Alzheimer tanto en sus fases sintomáticas como en la etapa preclínica (antes de que se manifiesten los síntomas). [...]
This thesis deepens in the knowledge of key aspects of neurodegenerative diseases, and more precisely in AD, both in symptomatic and preclinical stages. This is achieved through the study of CSF biomarkers that reflect in vivo the changes that take place in the brain very early in the disease process, and that are the central line of the thesis. [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2015  
9.
161 p, 1.9 MB Efecto de las manipulaciones genéticas y farmacológicas sobre la actividad del complejo gamma-secretasa / Guardia Laguarta, Cristina ; Lleó Bisa, Alberto, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Illa Sendra, Isabel, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona. Departament de Medicina
El objetivo de esta tesis fue estudiar el efecto de las manipulaciones farmacológicas y genéticas sobre el complejo gamma-secretasa. El estudio de estos cambios en el complejo gamma-secretasa es un buen modelo de las alteraciones proteicas que ocurren durante el avance de la enfermedad de Alzheimer. [...]
Bellaterra : Universitat Autònoma de Barcelona, 2010  

Materiales académicos Encontrados 1 registros  
1.
4 p, 74.8 KB Malalties neurodegeneratives i demències [101711] / Fontanals Muñoz, Ingrid ; Martí Fàbregas, Joan ; Auge Domenech, Laura ; Lleó Bisa, Alberto ; Universitat Autònoma de Barcelona. Facultat de Psicologia
El temari estudia les principals malalties neurodegeneratives que determinen trastorns cognitius i delllenguatge tant en la població infantil com en l'edat adulta, i prepara els alumnes per a l'estudi sistemàtic de la patologia del llenguatge i els trastorns neuropsicològics acompanyants originats per aquestes malalties,introduint-los en les tècniques específiques de rehabilitació. [...]
2017-18
Grau en Logopèdia [1383]  

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