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1.
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10 p, 1014.3 KB |
Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells
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Marcelo, Gonçalo A. (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia) ;
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Oliveira, Elisabete (PROTEOMASS Scientific Society)
Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. [...]
2020 -  10.1016/j.dyepig.2020.108393
Dyes and pigments, Vol. 181 (Oct. 2020) , art. 108393
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2.
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36 p, 2.5 MB |
Nanoscale coordination polymers for medicine and sensors
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Solorzano Rodríguez, Ruben (Institut Català de Nanociència i Nanotecnologia) ;
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia) ;
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Alibés Arqués, Ramon (Universitat Autònoma de Barcelona. Departament de Química) ;
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Miniaturization of coordination polymers to the nanoscale represents a unique opportunity to assemble a novel class of highly customizable functional materials that marry the rich diversity, chemistry and properties of coordination complexes to the advantages of nanomaterials. [...]
2020 - 10.1016/bs.adioch.2020.03.001
Advances in Inorganic Chemistry, Vol. 76 (2020) , p. 3-31
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3.
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29 p, 9.5 MB |
Substrate specificity of human metallocarboxypeptidase D : comparison of the two active carboxypeptidase domains
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Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tanco, Sebastián Martín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz, Lucía (Barcelona Supercomputing Center) ;
Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ;
Fernandez Recio, Juan (Barcelona Supercomputing Center) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD is a multicatalytic enzyme with three carboxypeptidase-like domains, although only the first two domains are predicted to be enzymatically active. [...]
2017 - 10.1371/journal.pone.0187778
PloS one, Vol. 12 issue 11 (2017) , art. e0187778
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4.
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51 p, 1.4 MB |
Dual T1/ T2 Nanoscale Coordination Polymers as Novel Contrast Agents for MRI : A Preclinical Study for Brain Tumor
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Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia) ;
Arias-Ramos, Nuria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Frías Botella, Carolina (Institut Català de Nanociència i Nanotecnologia) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)
In the last years, extensive attention has been paid on designing and developing functional imaging contrast agents for providing accurate noninvasive evaluation of pathology in vivo. However, the issue of false-positives or ambiguous imaging and the lack of a robust strategy for simultaneous dual-mode imaging remain to be fully addressed. [...]
2018 - 10.1021/acsami.8b15594
ACS applied materials & interfaces, Vol. 10, Issue 45 (November 2018) , p. 38819-38832
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5.
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29 p, 862.1 KB |
Crystal structure and mechanism of human carboxypeptidase O : insights into its specific activity for acidic residues
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García Guerrero, María del Carmen (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Garcia-Pardo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Berenguer de la Cuesta, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fernández Álvarez, Roberto (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Barfi, Gifty B. (Andrews University. Department of Biology) ;
Lyons, Peter J. (Andrews University. Department of Biology) ;
Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Huber, Robert (Technische Universität München) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human metallocarboxypeptidase O (hCPO) is a recently discovered digestive enzyme localized to the apical membrane of intestinal epithelial cells. Unlike pancreatic metallocarboxypeptidases, hCPO is glycosylated and produced as an active enzyme with distinctive substrate specificity toward C-terminal (C-t) acidic residues. [...]
2018 - 10.1073/pnas.1803685115
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 17 (April 2018) , p. E3932-E3939
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6.
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29 p, 560.9 KB |
Pt(IV)-based nanoscale coordination polymers : antitumor activity, cellular uptake and interactions with nuclear DNA
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Adarsh, Nayarassery N. (Institut Català de Nanociència i Nanotecnologia) ;
Frías Botella, Carolina (Institut Català de Nanociència i Nanotecnologia) ;
Ponnoth Lohidakshan, T.M. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia) ;
Garcia-Pardo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Cisplatin has been for many years the gold standard chemotherapeutic drug for the treatment of a wide range of solid tumors, even though its use is commonly associated with serious side effects including non-selective toxicity, myelosuppression or development of cisplatin resistance, among others complications. [...]
2018 - 10.1016/j.cej.2018.01.058
Chemical engineering journal, Vol. 340 (May 2018) , p. 94-102
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7.
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9 p, 1.1 MB |
Versatile iron-catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy
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Solórzano Rodríguez, Ruben (Institut Català de Nanociència i Nanotecnologia) ;
Tort Regàs, Olívia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Garcia-Pardo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Escribà, Tuixent (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Arnedo, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Alibés Arqués, Ramon (Universitat Autònoma de Barcelona. Departament de Química) ;
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ;
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)
A novel chemical approach integrating the benefits of nanoparticles with versatility of coordination chemistry is reported herein to increase the effectiveness of well-known HIV antiretroviral drugs. [...]
2019 - 10.1039/c8bm01221k
Biomaterials science, Vol. 7, Issue 1 (January 2019) , p. 178-186
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8.
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34 p, 1.7 MB |
Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles : Towards new protein scavengers and smart drug delivery carriers
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Oliveira, Elisabete (Proteomass Scientific Society) ;
Santos, Hugo M. (Proteomass Scientific Society) ;
Jorge, Susana (Proteomass Scientific Society) ;
Rodríguez-González, Benito (Scientific and Technological Research Assistance Centre) ;
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Capelo, José Luis (Proteomass Scientific Society) ;
Lodeiro, Carlos (Proteomass Scientific Society)
The synthesis and full characterization of a family of sustainable luminescent nanoparticles, CdTeQDs@MNs, made of quantum dots coated by modified mesoporous silica nanoparticles is reported. The presence of the luminescent QDs allows the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli). [...]
2019 - 10.1016/j.dyepig.2018.09.047
Dyes and pigments, Vol. 161 (February 2019) , p. 360-369
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9.
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20 p, 4.8 MB |
Silica coated iron/iron oxide nanoparticles as a nano-platform for T2 weighted magnetic resonance imaging
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Mathieu, Paul (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ;
Coppel, Yannick (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ;
Respaud, Marc (Institut National des Sciences Appliquées. Laboratoire de Physique et Chimie des Nano-objets) ;
Nguyen, Quyen T. (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ;
Boutry, Sébastien (University of Mons. Department of General, Organic and Biomedical Chemistry) ;
Laurent, Sophie (University of Mons. Department of General, Organic and Biomedical Chemistry) ;
Stanicki, Dimitri (University of Mons. Department of General, Organic and Biomedical Chemistry) ;
Henoumont, Céline (University of Mons. Department of General, Organic and Biomedical Chemistry) ;
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Amiens, Catherine (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)
The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron-iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. [...]
2019 - 10.3390/molecules24244629
Molecules, Vol. 24, issue 24 (Dec. 2019) , art. 4629
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10.
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11 p, 695.3 KB |
pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
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Aríñez Soriano, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Albalad, Jorge (Institut Català de Nanociència i Nanotecnologia) ;
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia) ;
Bonnet, Célia S. (Université d'Orléans) ;
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró) ;
Terban, Maxwell W. (Columbia University. Department of Applied Physics and Applied Mathematics) ;
Imaz, Inhar (Institut Català de Nanociència i Nanotecnologia) ;
Tóth, Éva (Université d'Orléans) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)
Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gdchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. [...]
2016 - 10.1002/chem.201602356
Chemistry, Vol. 22, Issue 37 (September 2016) , p. 13162-13170
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