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27 p, 8.1 MB |
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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Liang, Wen-Wei (Washington University in St. Louis) ;
Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ;
Jayasinghe, Reyka G. (Washington University in St. Louis) ;
Foltz, Steven M. (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ;
Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Kolodziejczak, Iga (Medical University of Warsaw) ;
Song, Yizhe (Washington University in St. Louis) ;
Govindan, Akshay (Washington University in St. Louis) ;
Demicco, Elisabeth G. (University of Toronto) ;
Li, Xiang (Washington University in St. Louis) ;
Li, Yize (Washington University in St. Louis) ;
Sethuraman, Sunantha (Washington University in St. Louis) ;
Payne, Samuel H. (Department of Biology. Brigham Young University) ;
Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ;
Wiznerowicz, Maciej (Poznań University of Medical Sciences) ;
Shen, Hui (Van Andel Research Institute) ;
Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ;
Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Ding, Li (Washington University in St. Louis) ;
Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 -  10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7
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18 p, 1.8 MB |
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
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Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Li, Jiarui (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wei, RanLei (Sichuan University. National Frontier Center of Disease Molecular Network) ;
Guidi, Irene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cozzuto, Luca (Centre de Regulació Genòmica) ;
Ponomarenko, Julia (Centre de Regulació Genòmica) ;
Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
RNase2 is the member of the RNaseA family most abundant in macrophages. Here, we knocked out RNase2 in THP-1 cells and analysed the response to Respiratory Syncytial Virus (RSV). RSV induced RNase2 expression, which significantly enhanced cell survival. [...]
2022 - 10.1007/s00018-022-04229-x
Cellular and Molecular Life Sciences, Vol. 79, Issue 4 (April 2022) , art. 209
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2 p, 186.0 KB |
Correction to : Lu et al. weighted gene co-expression network analysis identifies key modules and hub genes associated with mycobacterial infection of human macrophages. antibiotics 2021, 10, 97
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Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Waddell, Simon J. (University of Sussex. Brighton and Sussex Medical School) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wei, RanLei (Sichuan University. Laboratory of Omics Technology and Bioinformatics) ;
Bhakta, Sanjib (University of London. Department of Biological Sciences)
2021 - 10.3390/antibiotics10070792
Antibiotics, Vol. 10, Issue 7 (June 2021) , art. 792
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2.4 MB |
De novo Transcriptome Analysis and Molecular Marker Development of Two Hemarthria Species
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Huang, Xiu (Sichuan Agricultural University. Department of Grassland Science) ;
Yan, Hai-Dong (Sichuan Agricultural University. Department of Grassland Science) ;
Zhang, Xin-Quan (Sichuan Agricultural University. Department of Grassland Science) ;
Zhang, Jian (Herbivorous Livestock Research Institute) ;
Frazier, Taylor P. (Virginia State University. Department of Horticulture) ;
Huang, De-Jun (Herbivorous Livestock Research Institute) ;
Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Huang, Lin-Kai (Sichuan Agricultural University. Department of Grassland Science) ;
Liu, Wei (Sichuan Agricultural University. Department of Grassland Science) ;
Peng, Yan (Sichuan Agricultural University. Department of Grassland Science) ;
Ma, Xiao (Sichuan Agricultural University. Department of Grassland Science) ;
Yan, Yan-Hong (Sichuan Agricultural University. Department of Grassland Science)
Hemarthria R. Br. is an important genus of perennial forage grasses that is widely used in subtropical and tropical regions. Hemarthria grasses have made remarkable contributions to the development of animal husbandry and agro-ecosystem maintenance; however, there is currently a lack of comprehensive genomic data available for these species. [...]
2016 - 10.3389/fpls.2016.00496
Frontiers in plant science, Vol. 7 (April 2016) , art. 496
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21 p, 25.6 MB |
Structure-Based Design of an RNase Chimera for Antimicrobial Therapy
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Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorente, Helena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Villalba, Clara (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Anguita, Raúl (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vázquez-Monteagudo, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fernández-Millán, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Bacterial resistance to antibiotics urges the development of alternative therapies. Based on the structure-function of antimicrobial members of the RNase A superfamily, we have developed a hybrid enzyme. [...]
2022 - 10.3390/ijms23010095
International journal of molecular sciences, Vol. 23, Issue 1 (January 2022) , art. 95
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23 p, 6.4 MB |
Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model
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Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wei, RanLei (Sichuan University. Center of Precision Medicine) ;
Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Goetz, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wang, Gang (Sichuan University. Center of Precision Medicine) ;
Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The human RNase3 is a member of the RNaseA superfamily involved in host immunity. RNase3 is expressed by leukocytes and shows broad-spectrum antimicrobial activity. Together with a direct antimicrobial action, RNase3 exhibits immunomodulatory properties. [...]
2020 - 10.1007/s00018-020-03695-5
Cellular and Molecular Life Sciences, Vol. 78 (November 2020) , p. 2963-2985
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2 p, 437.5 KB |
Identificades noves propietats d'un enzim del sistema de defensa humà
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Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Goetz, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wang, Gang (Sichuan University. Laboratory of Omics Technology and Bioinformatics) ;
Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wei, RanLei (Sichuan University. Laboratory of Omics Technology and Bioinformatics) ;
Prats, Guillem, 1942- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
La ribonucleasa és un enzim que secreten els leucòcits quan es presenta una infecció, sigui per virus o per bacteris. En un estudi recent, el grup de recerca liderat per Ester Boix, del Departament de Bioquímica i de Biologia Molecular, ha identificat noves propietats immunomoduladors d'aquest enzim que es sumen a les activitats catalítiques, i antimicrobianes ja conegudes. [...]
La ribonucleasa es una enzima que secretan los leucocitos cuando se presenta una infección, ya sea por virus o por bacterias. En un estudio reciente, el grupo de investigación liderado por Ester Boix, del Departamento de Bioquímica y Biología Molecular, ha identificado nuevas propiedades inmunomoduladoras de esta molécula, que se suman a sus ya conocidas actividades catalíticas y antimicrobianas. [...]
Ribonuclease is an enzyme secreted by leukocytes when an infection occurs, either by viruses or bacteria. In a recent study, the research group led by Ester Boix from the Department of Biochemistry and Molecular Biology identified new immunomodulatory properties of this molecule, in addition to its already known catalytic and antimicrobial activities. [...]
2021
UAB divulga, Abril 2021
3 documents
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16 p, 3.9 MB |
Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages
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Lu, Lu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Waddell, Simon J. (University of Sussex. Brighton and Sussex Medical School) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Wei, RanLei (Sichuan University. Laboratory of Omics Technology and Bioinformatics) ;
Bhakta, Sanjib (University of London. Department of Biological Sciences)
Tuberculosis (TB) is still a leading cause of death worldwide. Treatments remain unsatisfactory due to an incomplete understanding of the underlying host-pathogen interactions during infection. In the present study, weighted gene co-expression network analysis (WGCNA) was conducted to identify key macrophage modules and hub genes associated with mycobacterial infection. [...]
2021 - 10.3390/antibiotics10020097
Antibiotics, Vol. 10, Num. 2 (February 2021) , art. 97
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