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Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
14 p, 7.3 MB Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase / Brissos, Vânia (Universidade Nova de Lisboa) ; Borges, Patrícia T. (Universidade Nova de Lisboa) ; Núñez-Franco, Reyes (Zymvol Biomodeling) ; Lucas, Maria Fátima (Zymvol Biomodeling) ; Frazão, Carlos (Universidade Nova de Lisboa) ; Monza, Emanuele (Zymvol Biomodeling) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Departament de Química) ; Cordeiro, Tiago N. (Universidade Nova de Lisboa) ; Martins, Lígia O. (Universidade Nova de Lisboa)
Laccases are in increasing demand as innovative solutions in the biorefinery fields. Here, we combine mutagenesis with structural, kinetic, and in silico analyses to characterize the molecular features that cause the evolution of a hyperthermostable metallo-oxidase from the multicopper oxidase family into a laccase (k 273 s -1 for a bulky aromatic substrate). [...]
2022 - 10.1021/acscatal.2c00336
ACS catalysis, Vol. 12, Issue 9 (April 2022) , p. 5022-5035  
Registro completo - Creative Commons
2.
13 p, 1.7 MB Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity / Liu, Qing (University of Copenhagen. Department of Plant and Environmental Sciences) ; Beyraghdar Kashkooli, Arman (Wageningen University and Research. Laboratory of Plant Physiology) ; Manzano, David (Centre de Recerca en Agrigenòmica) ; Pateraki, Irini (University of Copenhagen. Department of Plant and Environmental Sciences) ; Richard, Lea (Wageningen University and Research. Laboratory of Plant Physiology) ; Kolkman, Pim (Wageningen University and Research. Laboratory of Plant Physiology) ; Lucas, Maria Fátima (Barcelona Supercomputing Center) ; Guallar, Victor (Institució Catalana de Recerca i Estudis Avançats) ; de Vos, Ric C. H. (Wageningen University and Research. Wageningen Plant Research) ; Franssen, Maurice C. R. (Wageningen University. Laboratory of Organic Chemistry) ; van der Krol, Alexander (Wageningen University and Research. Laboratory of Plant Physiology) ; Bouwmeester, Harro (University of Amsterdam. Swammerdam Institute for Life Sciences)
Guaianolides are an important class of sesquiterpene lactones with unique biological and pharmaceutical properties. They have been postulated to be derived from germacranolides, but for years no progress has been made in the elucidation of their biosynthesis that requires an unknown cyclization mechanism. [...]
2018 - 10.1038/s41467-018-06565-8
Nature communications, Vol. 9 (November 2018) , art. 4657  
Registro completo - Creative Commons

Vea también: autores con nombres similares
1 Lucas, M. Mercedes
1 Lucas, M.F.
1 Lucas, María
3 Lucas, Michaela
1 Lucas, Miguel
1 Lucas, Miguel de
1 Lucas, Mikkel
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