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1.
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33 p, 8.1 MB |
Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis
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Cavalcanti, Fernando (Oryzon Genomics S.A) ;
Gonzalez-Rey, Elena (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Delgado, Mario (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Falo, Clara P. (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
O'Valle, Francisco (Univeridad de Granada. Departamento de Patologia) ;
Lufino, Michele M. P. (Oryzon Genomics S.A) ;
Xaus, Jordi (Oryzon Genomics S.A) ;
Mascaró, Cristina (Oryzon Genomics S.A) ;
Lunardi, Serena (Oryzon Genomics S.A) ;
Sacilotto, Natalia (Oryzon Genomics S.A) ;
Dessanti, Paola (Oryzon Genomics S.A) ;
Rotllant, David (Oryzon Genomics S.A) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Buesa, Carlos (Oryzon Genomics S.A) ;
Maes, Tamara (Oryzon Genomics S.A)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of diseases such as cancer, central nervous system (CNS) disorders, viral infections, and others. [...]
2022 -  10.3390/pharmaceutics14071420
Pharmaceutics, Vol. 14 Núm. 7 (2022) , p. 1420
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2.
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15 p, 1.2 MB |
First-in-Human Phase I Study of Iadademstat (ORY-1001) : A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
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Salamero, Olga (Vall d'Hebron Institut d'Oncologia) ;
Montesinos, Pau (Centro de Investigación Biomédica en Red de Cáncer) ;
Willekens, Christophe (Institut Gustave Roussy (Villejuif, França)) ;
Pérez-Simón, José Antonio (Universidad de Sevilla) ;
Pigneux, Arnaud (Centre Hospitalier Universitaire CHU Bordeaux) ;
Récher, Christian (Hospitalier Universitaire de Toulouse) ;
Popat, Rakesh (University College London) ;
Carpio Segura, Cecilia del Carmen (Vall d'Hebron Institut d'Oncologia) ;
Molinero, César (Parc Científic de Barcelona. Oryzon Genomics) ;
Mascaró, Cristina (Parc Científic de Barcelona. Oryzon Genomics) ;
Vila, Joaquim (Parc Científic de Barcelona. Oryzon Genomics) ;
Arévalo, M. Isabel (Parc Científic de Barcelona. Oryzon Genomics) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics) ;
Buesa, Carlos (Parc Científic de Barcelona. Oryzon Genomics) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Somervaille, Tim (The University of Manchester) ;
Universitat Autònoma de Barcelona
This phase I, nonrandomized, open-label, dose-escalation (DE), and extension-cohort (EC) trial included patients with R/R AML and evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase 1 inhibitor. [...]
2020 - 10.1200/JCO.19.03250
Journal of Clinical Oncology, Vol. 38 (october 2020) , p. 4260-4273
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3.
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26 p, 3.8 MB |
Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations
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Maes, Tamara (Oryzon Genomics, S.A) ;
Mascaró, Cristina (Oryzon Genomics, S.A) ;
Rotllant, David (Oryzon Genomics, S.A) ;
Lufino, Michele Matteo Pio (Oryzon Genomics, S.A) ;
Estiarte, Angels (Oryzon Genomics, S.A) ;
Guibourt, Nathalie (Oryzon Genomics, S.A) ;
Cavalcanti, Fernando (Oryzon Genomics, S.A) ;
Griñan-Ferré, Christian (Universitat de Barcelona. Institut de Neurociències) ;
Pallàs, Mercè (Universitat de Barcelona. Institut de Neurociències) ;
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ferrer, Isidro (Institut d'Investigació Biomèdica de Bellvitge) ;
Ortega, Alberto (Oryzon Genomics, S.A) ;
Valls, Nuria (Oryzon Genomics, S.A) ;
Fyfe, Matthew (Oryzon Genomics, S.A) ;
Martinell, Marc (Oryzon Genomics, S.A) ;
Castro Palomino, Julio César (Oryzon Genomics, S.A) ;
Buesa, Carlos (Oryzon Genomics, S.A)
Transcription disequilibria are characteristic of many neurodegenerative diseases. The activity-evoked transcription of immediate early genes (IEGs), important for neuronal plasticity, memory and behavior, is altered in CNS diseases and governed by epigenetic modulation. [...]
2020 - 10.1371/journal.pone.0233468
PloS one, Vol. 15 (may 2020)
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4.
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14 p, 2.2 MB |
First-in-Human Randomized Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the KDM1A Inhibitor Vafidemstat
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Antonijoan Arbós, Rosa Ma (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Ferrero-Cafiero, Juan Manuel (Institut d'Investigació Biomèdica Sant Pau) ;
Coimbra, Jimena (Institut d'Investigació Biomèdica Sant Pau) ;
Puntes, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Colomer, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Arévalo, M. Isabel (Parc Científic de Barcelona. Oryzon Genomics) ;
Mascaró, Cristina (Parc Científic de Barcelona. Oryzon Genomics) ;
Molinero, Cesar (Parc Científic de Barcelona. Oryzon Genomics) ;
Buesa, Carlos (Parc Científic de Barcelona. Oryzon Genomics) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics)
Vafidemstat, an inhibitor of the histone lysine-specific demethylase KDM1A, corrects cognition deficits and behavior alterations in rodent models. Here, we report the results from the first-in-human trial of vafidemstat in healthy young and older adult volunteers. [...]
2021 - 10.1007/s40263-021-00797-x
CNS Drugs, march 2021, p. 1-14
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5.
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9 p, 525.8 KB |
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
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Barrachina, Marta (Hospital Universitari de Bellvitge) ;
Castaño, Esther (Universitat de Barcelona) ;
Dalfo, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics) ;
Buesa, Carlos (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental)
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. [...]
2006 - 10.1016/j.nbd.2005.11.005
Neurobiology of disease, Vol. 22, Num. 2 (2006) , p. 265-73
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6.
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14 p, 1.6 MB |
Genomic resources for a commercial flatfish, the Senegalese sole (Solea senegalensis) : EST sequencing, oligo microarray design, and development of the Soleamold bioinformatic platform
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Cerdà Luque, Joan (Institut de Recerca i Tecnologia Agroalimentàries) ;
Mercadé, Jaume (Parc Científic de Barcelona. Oryzon Genomics) ;
Lozano, Juan José (Hospital Clínic i Provincial de Barcelona) ;
Manchado, Manuel (Andalusia. Junta. IFAPA Centro "El Toruño") ;
Tingaud-Sequeira, Angèle (Institut de Recerca i Tecnologia Agroalimentàries) ;
Astola, Antonio (Instituto de Ciencias Marinas de Andalucía) ;
Infante, Carlos (Andalusia. Junta. IFAPA Centro "El Toruño") ;
Halm, Silke (Instituto de Ciencias Marinas de Andalucía) ;
Viñas, Jordi (Institut de Ciències del Mar) ;
Castellana, Barbara (Universitat de Barcelona. Departament de Fisiologia) ;
Asensio, Esther (Andalusia. Junta. IFAPA Centro "El Toruño") ;
Cañavate, Pedro (Andalusia. Junta. IFAPA Centro "El Toruño") ;
Martínez-Rodríguez, Gonzalo (Instituto de Ciencias Marinas de Andalucía) ;
Piferrer i Circuns, Francesc (Institut de Ciències del Mar) ;
Planas, Josep V. (Universitat de Barcelona. Departament de Fisiologia) ;
Prat, Francesc (Instituto de Ciencias Marinas de Andalucía) ;
Yúfera, Manuel (Instituto de Ciencias Marinas de Andalucía) ;
Durany, Olga (Parc Científic de Barcelona. Oryzon Genomics) ;
Subirada, Francesc (Parc Científic de Barcelona. Oryzon Genomics) ;
Rosell, Elisabet (Parc Científic de Barcelona. Oryzon Genomics) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics)
Background: The Senegalese sole, Solea senegalensis, is a highly prized flatfish of growing commercial interest for aquaculture in Southern Europe. However, despite the industrial production of Senegalese sole being hampered primarily by lack of information on the physiological mechanisms involved in reproduction, growth and immunity, very limited genomic information is available on this species. [...]
2008 - 10.1186/1471-2164-9-508
BMC genomics, Vol. 9, N. 508 (October 2008) , p. 1-14
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12 p, 611.8 KB |
Orymold : ontology based gene expression data integration and analysis tool applied to rice
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Mercadé, Jaume (Parc Científic de Barcelona. Oryzon Genomics) ;
Espinosa, Antonio (Parc Científic de Barcelona. Oryzon Genomics) ;
Adsuara, José-Enrique (Parc Científic de Barcelona. Oryzon Genomics) ;
Adrados, Rosa (Parc Científic de Barcelona. Oryzon Genomics) ;
Segura, Jordi (Parc Científic de Barcelona. Oryzon Genomics) ;
Puigdomènech, Pere, 1948- (Parc Científic de Barcelona. Oryzon Genomics) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics)
Background: Integration and exploration of data obtained from genome wide monitoring technologies has become a major challenge for many bioinformaticists and biologists due to its heterogeneity and high dimensionality. [...]
2009 - 10.1186/1471-2105-10-158
BMC bioinformatics, Vol. 10, N. 158 (May 2009) , p. 1-12
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