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9 p, 765.5 KB Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia / Vázquez, Iria (Universidad de Navarra. CIMA) ; Maicas, Miren (Universidad de Navarra. Departamento de Genética) ; Cervera, José (Hospital Universitario La Fe) ; Agirre, Xabier (Universidad de Navarra. CIMA) ; Marin-Béjar, Oskar (Universidad de Navarra. CIMA) ; Marcotegui, Nerea (Universidad de Navarra. CIMA) ; Vicente, Carmen (Universidad de Navarra. CIMA) ; Lahortiga, Idoya (Human Genome Laboratory. Department of Molecular and Developmental Genetics. VIB) ; Gomez-Benito, Maria (Universidad de Navarra. CIMA) ; Carranza, Claudia (Instituto de Investigación Genética (Milpas Altas, Guatemala)) ; Valencia, Ana (Hospital Universitario La Fe) ; Brunet, Salut (Institut d'Investigació Biomèdica Sant Pau) ; Lumbreras, Eva (Universidad de Salamanca. Hospital Universitario de Salamanca y CSIC) ; Prosper, Felipe (Universidad de Navarra. CIMA) ; Gómez-Casares, Maria Teresa (Hospital Dr. Negrin (Las Palmas de Gran Canaria)) ; Hernández Rivas, Jesús María (Hospital Universitario de Salamanca) ; Calasanz, María J. (Universidad de Navarra. Departamento de Genética) ; Sanz, Miguel A. (Hospital Universitario La Fe) ; Sierra Gil, Jorge (Institut d'Investigació Biomèdica Sant Pau) ; Odero, María D. (Universidad de Navarra. Departamento de Genética) ; Universitat Autònoma de Barcelona
Background: The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis. Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia. [...]
2011 - 10.3324/haematol.2011.040535
Haematologica, Vol. 96, Núm. 10 (october 2011) , p. 1448-1456  

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1 Maicas, M
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