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14 p, 23.8 MB Shining Light On An mGlu5 Photoswitchable NAM : A Theoretical Perspective / Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira Algans, Xavier (Institut de Génomique Fonctionnelle) ; Malhaire, Fanny (Institut de Génomique Fonctionnelle) ; Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institute for Bioengineering of Catalonia (IBEC)) ; Gorostiza, Pau (Institute for Bioengineering of Catalonia (IBEC)) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Goudet, Cyril (Institut de Génomique Fonctionnelle) ; Pin, Jean-Philippe (Institut de Génomique Fonctionnelle) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. [...]
2016 - 10.2174/1570159X13666150407231417
Curr Neuropharmacol, Vol. 14, Num. 5 (2016) , p. 441-454  

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