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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 -  10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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2.
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10 p, 970.5 KB |
Impact of prehabilitation during neoadjuvant chemotherapy and interval cytoreductive surgery on ovarian cancer patients : a pilot study
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Miralpeix, Ester (Hospital del Mar (Barcelona, Catalunya)) ;
Sole-Sedeno, Josep-Maria (Hospital del Mar (Barcelona, Catalunya)) ;
Rodriguez-Cosmen, Cristina (Hospital del Mar (Barcelona, Catalunya)) ;
Taus, Alvaro (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Muns, Maria-Dolors (Hospital del Mar (Barcelona, Catalunya)) ;
Fabregó, Berta (Hospital del Mar (Barcelona, Catalunya)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Cytoreductive surgery followed by systemic chemotherapy is the standard of treatment in advanced ovarian cancer where feasible. Neoadjuvant chemotherapy (NACT) followed by surgery is applicable where upfront cytoreductive surgery is not feasible because of few certain reasons. [...]
2022 - 10.1186/s12957-022-02517-1
World Journal of Surgical Oncology, Vol. 20 (february 2022)
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3.
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7 p, 1.1 MB |
Prognostic impact of CD133 expression in Endometrial Cancer Patients
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Mancebo, Gemma (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sole-Sedeno, J. M. (Hospital del Mar (Barcelona, Catalunya)) ;
Pino, O. (Universitat Pompeu Fabra) ;
Miralpeix, E. (Hospital del Mar (Barcelona, Catalunya)) ;
Mojal, S. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrigós Cubells, Laia (Vall d'Hebron Institut d'Oncologia) ;
Lloveras, B. (Hospital del Mar (Barcelona, Catalunya)) ;
Navarro, Pilar (Institut d'Investigacions Biomèdiques de Barcelona) ;
Gibert, J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lorenzo, M. (Hospital del Mar (Barcelona, Catalunya)) ;
Aran Ballesta, Iris (Hospital del Mar (Barcelona, Catalunya)) ;
Carreras, Ricard (Hospital del Mar (Barcelona, Catalunya)) ;
Alameda, Francesc (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
To assess the impact of CD133 expression on the prognosis of endometrioid endometrial carcinoma (EEC). We retrospectively assessed CD133 expression in tissue microarray of 116 surgically treated FIGO I-III EEC. [...]
2017 - 10.1038/s41598-017-08048-0
Scientific reports, Vol. 7 (august 2017)
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4.
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19 p, 1.5 MB |
Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model : A development and validation study
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Reijnen, Casper (Radboud University Medical Center) ;
Gogou, Evangelia (Radboud University) ;
Visser, Nicole C. M. (Radboud University Medical Center) ;
Engerud, Hilde (Haukeland University Hospital (Bergen, Noruega)) ;
Ramjith, Jordache (Radboud University Medical Center) ;
van der Putten, Louis J. M. (Radboud University Medical Center) ;
van de Vijver, Koen (Universitair Ziekenhuis Gent) ;
Santacana, Maria (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Bronsert, Peter (University Medical Center, Freiburg, Germany) ;
Bulten, Johan (Radboud University Medical Center) ;
Hirschfeld, Marc (University Medical Center, Freiburg, Germany) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Krakstad, Camilla (Haukeland University Hospital (Bergen, Noruega)) ;
Trovik, Jone (Haukeland University Hospital (Bergen, Noruega)) ;
Haldorsen, Ingfrid S. (University of Bergen) ;
Huvila, Jutta (University of Turku) ;
Koskas, Martin (Bichat-Claude Bernard Hospital, Paris) ;
Weinberger, Vit (University Hospital Brno (República Txeca)) ;
Bednarikova, Marketa (University Hospital Brno (República Txeca)) ;
Hausnerova, Jitka (University Hospital Brno (República Txeca)) ;
van der Wurff, Anneke A. M. (Elisabeth-TweeSteden Hospital, Tilburg) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Amant, Frederic (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Massuger, Leon F. A. G. (Radboud University Medical Center) ;
Snijders, Marc P. L. M. (Canisius-Wilhelmina Hospital) ;
Küsters-Vandevelde, Heidi V. N. (Canisius-Wilhelmina Hospital) ;
Lucas, Peter J. F. (University of Twente) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center)
Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical decision-making. [...]
2020 - 10.1371/journal.pmed.1003111
PLoS Medicine, Vol. 17 (may 2020)
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5.
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8 p, 6.1 MB |
Poor outcome in hypoxic endometrial carcinoma is related to vascular density
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Reijnen, Casper (Radboud University Medical Center) ;
van Weelden, Willem Jan (Radboud University Medical Center) ;
Arts, Martijn S. J. P. (Radboud University Medical Center) ;
Peters, Johan P. (Radboud University Medical Center) ;
Rijken, Paul F. (Radboud University Medical Center) ;
van de Vijver, Koen (Universitair Ziekenhuis Gent) ;
Santacana, Maria (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Bronsert, Peter (Universitätsklinikum Freiburg) ;
Bulten, Johan (Radboud University Medical Center) ;
Hirschfeld, Marc (Universitätsklinikum Freiburg) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Krakstad, Camilla (Haukeland universitetssjukehus) ;
Trovik, Jone (Haukeland universitetssjukehus) ;
Haldorsen, Ingfrid S. (Universitetet i Bergen) ;
Huvila, Jutta (Turun Yliopisto) ;
Koskas, Martin (Hôpital Bichat - Claude-Bernard) ;
Weinberger, Vit (Masarykova univerzita) ;
Minar, Lubos (Masarykova univerzita) ;
Jandakova, Eva (Masarykova univerzita) ;
Snijders, Marc P. L. M. (Canisius Wilhelmina Ziekenhuis) ;
van den Berg-van Erp, Saskia (Canisius Wilhelmina Ziekenhuis) ;
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Ziekenhuis) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Amant, Frederic (Katholieke Universiteit Leuven) ;
Massuger, Leon F. A. G. (Radboud University Medical Center) ;
Bussink, Johan (Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). [...]
2019 - 10.1038/s41416-019-0461-2
British Journal of Cancer, Vol. 120 (april 2019) , p. 1037-1044
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6.
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17 p, 4.8 MB |
ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer
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Devis Jauregui, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quiles, Maria Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arbós i Via, Maria Antònia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Stirbat, Tomita Vasilica (Institut Curie) ;
Brochard-Wyart, Françoise (Institut Curie) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Alonso-Alconada, Lorena (Centro de Investigación Biomédica en Red de Cáncer) ;
Abal Posada, Miguel (Centro de Investigación Biomédica en Red de Cáncer) ;
Díaz-Feijoo, Berta (Hospital Universitari Vall d'Hebron) ;
Thomas, William (Department of Natural Sciences, Colby-Sawyer College, New London, New Hampshire, United States of America) ;
Dufour, Sylvie (Present address: Université Paris Est, Faculté de Médecine, Créteil, France, INSERM, U955, Equipe 6, Créteil, France) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Alameda, Francesc (Hospital del Mar (Barcelona, Catalunya)) ;
Reventos, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and mortality. [...]
2018 - 10.18632/oncotarget.24625
Oncotarget, Vol. 9 (march 2018) , p. 16648-16664
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9 p, 341.1 KB |
L1CAM expression in endometrial carcinomas : an ENITEC collaboration study
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van der Putten, Louis J. M. (Department of Obstetrics and Gynaecology, Radboud University Medical Center) ;
Visser, Nicole C. M. (Department of Pathology, Radboud University Medical Center) ;
van de Vijver, Koen (Department of Pathology, Anthoni van Leeuwenhoek Hospital) ;
Santacana, Maria (Institut de Recerca Biomèdica de Lleida) ;
Bronsert, Peter (Institute of Pathology, University Medical Center Freiburg) ;
Bulten, Johan (Department of Pathology, Radboud University Medical Center) ;
Hirschfeld, Marc (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia, Angel (Hospital Universitari Vall d'Hebron) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Alameda, Francesc (Hospital del Mar (Barcelona, Catalunya)) ;
Trovik, Jone (Haukeland University Hospital (Bergen, Noruega)) ;
Kopperud, Reidun K. (Center for Cancer Biomarkers (CCBIO), University of Bergen) ;
Huvila, Jutta (University of Turku. Department of Pathology) ;
Schrauwen, Stefanie (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital) ;
Walker, Francine (Department of Pathology, Bichat-Claude Bernard Hospital) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University) ;
Minar, Lubos (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University) ;
Jandakova, Eva (Institute of Pathology, Faculty of Medicine, Masaryk University) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital) ;
van den Berg-van Erp, Saskia (Department of Pathology, Canisius-Wilhelmina Hospital) ;
Matias-Guiu, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Salvesen, Helga B. (Haukeland University Hospital (Bergen, Noruega)) ;
Amant, Frederic (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Massuger, Leon FAG (Department of Obstetrics and Gynaecology, Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Department of Obstetrics and Gynaecology, TweeSteden Hospital) ;
Universitat Autònoma de Barcelona
Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. [...]
2016 - 10.1038/bjc.2016.235
British Journal of Cancer, Vol. 115 (08 2016) , p. 716-724
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