Results overview: Found 4 records in 0.03 seconds.
Articles, 4 records found
Articles 4 records found  
1.
17 p, 352.4 KB Synaptic failure : focus in an integrative view of ALS / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (Universidad de Zaragoza) ; Vaz, Rita (Universidade de Lisboa. Faculdade de Farmácia) ; Osta, Rosario (Universidad de Zaragoza) ; Brites, Dora (Universidade de Lisboa. Faculdade de Farmácia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
From early description by Charcot, the classification of the Amyotrophic Lateral Sclerosis (ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a multi-systemic, non-cell autonomous and complex neurodegenerative disease. [...]
2016 - 10.3233/BPL-140001
Brain plasticity, Vol. 1, issue 2 (2016) , p. 159-175  
2.
10 p, 3.4 MB Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy / Oliván, Sara (Universidad de Zaragoza. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina. Grupo AMB.) ; Calvo, Ana C. (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Herrando Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ; Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón (IA2)) ; Tizzano, Eduardo F. (Hospital Vall d'Hebron. Àrea de Genètica Clínica i Molecular. Centros de Investigación Biomédica en Red) ; Aguilera Ávila, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza. Centro de Investigación y Tecnología Agroalimentaria de Aragón) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in Molecular Neuroscience, Vol. 9 (August 2016) , art. 76  
3.
14 p, 11.1 MB Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Herrando Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (Universidad de Zaragoza) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sporadic and familiar amyotrophic lateral sclerosis (ALS) cases presented lower cholinergic activity than in healthy individuals in their still preserved spinal motoneurons (MNs) suggesting that cholinergic reduction might occur before MN death. [...]
2013 - 10.1002/brb3.104
Brain and Behavior, Vol. 3, Núm. 2 (February 2013) , p. 145-158  
4.
19 p, 3.9 MB Fragment C of Tetanus Toxin : New Insights into Its Neuronal Signaling Pathway / Calvo Royo, Ana Cristina (Universidad de Zaragoza. Facultad de Veterinaria) ; Oliván, Sara (Universidad de Zaragoza. Facultad de Veterinaria) ; Manzano, Raquel (Universidad de Zaragoza. Facultad de Veterinaria) ; Zaragoza Fernández, Pilar (Universidad de Zaragoza. Facultad de Veterinaria) ; Aguilera Ávila, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Osta, Rosario (Universidad de Zaragoza. Facultad de Veterinaria)
When Clostridium tetani was discovered and identified as a Gram-positive anaerobic bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable biological carrier to ameliorate neurodegenerative processes was inconceivable. [...]
2012 - 10.3390/ijms13066883
International Journal of Molecular Sciences, Vol. 13 (2012) , p. 6883-6901  

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