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Articles, 2 records found
Articles 2 records found  
1.
17 p, 9.8 MB Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice / Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ; Colell, Guillem (Hospital Universitari Vall d'Hebron) ; Bonaterra, Anna (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Institut d'Investigació Biomèdica Sant Pau) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Background: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cerebral accumulation is not clear yet. [...]
2019 - 10.1186/s13195-019-0498-8
Alzheimer's research & therapy, Vol. 11 (May 2019) , art. 42  
2.
13 p, 3.3 MB Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis / Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Institut d'Investigació Biomèdica Sant Pau) ; García León, Annabel (Institut d'Investigació Biomèdica Sant Pau) ; Montañola, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Cerebral β-amyloidosis is a major feature of Alzheimer's disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. [...]
2017 - 10.1038/s41598-017-15215-w
Scientific reports (Nature Publishing Group), Vol. 7 (November 2017) , art. 14637  

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