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Articles, 2 records found
Articles 2 records found  
1.
17 p, 9.8 MB Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice / Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ; Colell, Guillem (Hospital Universitari Vall d'Hebron) ; Bonaterra, Anna (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau) ; Montaner, Joan (Vall d'Hebron Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca)
Background: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cerebral accumulation is not clear yet. [...]
2019 - 10.1186/s13195-019-0498-8
Alzheimer's research and therapy, Vol. 11 (May 2019) , art. 42  
2.
13 p, 3.3 MB Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis / Fernández de Retana Alda, Sofía (Vall d'Hebron Institut de Recerca) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau) ; García León, Annabel (Institut d'Investigacions Biomèdiques Sant Pau) ; Montañola, Alex (Vall d'Hebron Institut de Recerca) ; Montaner, Joan (Vall d'Hebron Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca)
Cerebral β-amyloidosis is a major feature of Alzheimer's disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. [...]
2017 - 10.1038/s41598-017-15215-w
Scientific reports, Vol. 7 (November 2017) , art. 14637  

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