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Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males / Baldassarri, Margherita (University of Siena. Department of Medical Biotechnologies) ; Picchiotti, Nicola (University of Pavia. Department of Mathematics) ; Fava, Francesca (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Fallerini, Chiara (University of Siena. Department of Medical Biotechnologies) ; Benetti, Elisa (University of Siena. Department of Medical Biotechnologies) ; Daga, Sergio (University of Siena. Department of Medical Biotechnologies) ; Valentino, Floriana (University of Siena. Department of Medical Biotechnologies) ; Doddato, Gabriella (University of Siena. Department of Medical Biotechnologies) ; Furini, Simone (University of Siena. Department of Medical Biotechnologies) ; Giliberti, Annarita (University of Siena. Department of Medical Biotechnologies) ; Tita, Rossella (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Amitrano, Sara (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Bruttini, Mirella (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Croci, Susanna (University of Siena. Department of Medical Biotechnologies) ; Meloni, Ilaria (University of Siena. Department of Medical Biotechnologies) ; Pinto, Anna Maria (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Iuso, Nicola (University of Siena. Department of Medical Biotechnologies) ; Gabbi, Chiara ; Sciarra, Francesca (Sapienza University of Rome. Department of Experimental Medicine) ; Venneri, Mary Anna (Sapienza University of Rome. Department of Experimental Medicine) ; Gori, Marco (Université Côte d'Azur) ; Sanarico, Maurizio ; Crawley, Francis P. (Good Clinical Practice Alliance-Europe (GCPA) and Strategic Initiative for Developing Capacity in Ethical Review-Europe (SIDCER) (Leuven, Bèlgica)) ; Pagotto, Uberto (University of Bologna. Department of Medical and Surgical Sciences) ; Fanelli, Flaminia (University of Bologna. Department of Medical and Surgical Sciences) ; Mezzullo, Marco (University of Bologna. Department of Medical and Surgical Sciences) ; Domínguez-Garrido, Elena (Fundación Rioja Salud. Molecular Diagnostic Unit) ; Planas-Serra, Laura (Spanish Covid HGE) ; Schlüter, Agatha (Spanish Covid HGE) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lapunzina, Pablo (Hospital Universitario La Paz (Madrid)) ; Tenorio, Jair (Hospital Universitario La Paz (Madrid)) ; Pujol, Aurora 1968- (Institució Catalana de Recerca i Estudis Avançats) ; Castagna, Maria Grazia (University of Siena. Department of Medical, Surgical and Neurological Sciences) ; Marcelli, Marco (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Department of Medicine) ; Isidori, Andrea M. (Sapienza University of Rome. Department of Experimental Medicine) ; Renieri, Alessandra (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Frullanti, Elisa (University of Siena. Department of Medical, Surgical and Neurological Sciences) ; Mari, Francesca (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Universitat Autònoma de Barcelona
While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. [...]
2021 - DOI (Digital Object Identifier)

10.1016/j.ebiom.2021.103246
EBioMedicine, Vol. 65 (february 2021) , p. 103246

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