Results overview: Found 5 records in 0.02 seconds.
Articles, 4 records found
Research literature, 1 records found
Articles 4 records found  
1.
615.4 KB ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy / Marco-Contelles, José (Laboratori de Química Mèdica, Institut de Química Orgànica General (CSIC), Madrid) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Esteban, Gerard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ramsay, Rona R. (Biomedical Sciences Research Complex, University of St Andrews) ; Romero, Alejandro (Universidad Complutense de Madrid) ; Martínez-Murillo, Ricard (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Carreiras, M. Carmo (University of Lisbon) ; Ismaili, Lhassane (Université Bourgogne Franche-Comté)
Highlights: The complex nature of Alzheimer's disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. [...]
2016 - 10.3389/fnins.2016.00294
Frontiers in Neuroscience, Vol. 10 (june 2016)  
2.
21 p, 3.7 MB Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke / Martínez-Alonso, Emma (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Escobar-Peso, Alejandro (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Ayuso, Maria I. (Instituto de Biomedicina de Sevilla) ; Gonzalo Gobernado, Rafael (Instituto de Biomedicina de Sevilla) ; Chioua, Mourad (Laboratory of Medicinal Chemistry (Madrid)) ; Montoya, Juan J. (Isquaemia Biotech (Córdoba)) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández, Israel (Universidad Complutense de Madrid) ; Marco-Contelles, José (Laboratory of Medicinal Chemistry (Madrid)) ; Alcázar, Alberto (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Universitat Autònoma de Barcelona
Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. [...]
2020 - 10.3390/antiox9040291
Antioxidants, Vol. 9 (march 2020)  
3.
24 p, 5.9 MB Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease / Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ; Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ; Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ; Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205  
4.
18 p, 2.9 MB Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease : design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids / Bautista-Aguilera, Oscar M.. (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Esteban, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chioua, Mourad (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Nikolic, Katarina (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Agbaba, Danica (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Moraleda, Ignacio (Universidad de Alcalá. Departamento de Química Orgánica) ; Iriepa, Isabel (Universidad de Alcalá. Departamento de Química Orgánica) ; Soriano, Elena (Instituto de Química Orgánica General (IQOG-CSIC). Síntesis y estructura de compuestos orgánicos (SEPCO)) ; Samadi, Abdelouahid (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Marco-Contelles, José (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
The design, synthesis, and biochemical evaluation of donepezil-pyridyl hybrids (DPHs) as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. [...]
2014 - 10.2147/DDDT.S69258
Drug Design, Development and Therapy, Vol. 8 (October 2014) , p. 1893-1910  

Research literature 1 records found  
1.
385 p, 13.9 MB Biological assessment of novel series of Multitarget-Directed Ligands based on donepezil to be used in Alzheimer's disease therapy / Esteban, Gerard ; Unzeta López, Mercedes, dir. ; Marco Contelles, José Luis, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
En l'actualitat, el tractament de la malaltia d'Alzheimer es basa principalment en l'ús d'inhibidors de colinesterases, els quals, juntament amb un antagonista de receptor NMDA han estat aprovats per la FDA. [...]
The current treatment of Alzheimer's disease is essentially based on the use of cholinesterase inhibitors that together with a NMDA receptor antagonist have been approved by the FDA. Nevertheless, the use of these drugs in therapy has been reported ineffective accompanied with temporary sympomatic benefits. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  

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