Resultados globales: 3 registros encontrados en 0.02 segundos.
Artículos, Encontrados 2 registros
Documentos de investigación, Encontrados 1 registros
Artículos Encontrados 2 registros  
1.
24 p, 5.9 MB Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease / Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ; Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ; Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ; Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205  
2.
18 p, 2.9 MB Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease : design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids / Bautista-Aguilera, Oscar M (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Esteban Conde, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chioua, Mourad (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Nikolic, Katarina (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Agbaba, Danica (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Moraleda, Ignacio (Universidad de Alcalá. Facultat de Farmacia. Departamento de Química Orgánica) ; Iriepa, Isabel (Universidad de Alcalá. Facultat de Farmacia. Departamento de Química Orgánica) ; Soriano, Elena (Instituto de Química Orgánica General (IQOG-CSIC). Síntesis y estructura de compuestos orgánicos (SEPCO)) ; Samadi, Abdelouahid (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Marco-Contelles, José (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Universitat Autònoma de Barcelona. Departament de Bioquímca i Biologia Molecular
The design, synthesis, and biochemical evaluation of donepezil-pyridyl hybrids (DPHs) as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. [...]
2014 - 10.2147/DDDT.S69258
Drug Design, Development and Therapy, Vol. 8 (October 2014) , p. 1893-1910  

Documentos de investigación Encontrados 1 registros  
1.
385 p, 13.9 MB Biological assessment of novel series of Multitarget-Directed Ligands based on donepezil to be used in Alzheimer's disease therapy / Esteban Conde, Gerard ; Unzeta López, Mercedes, dir. ; Marco Contelles, José Luis, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
En l'actualitat, el tractament de la malaltia d'Alzheimer es basa principalment en l'ús d'inhibidors de colinesterases, els quals, juntament amb un antagonista de receptor NMDA han estat aprovats per la FDA. [...]
The current treatment of Alzheimer's disease is essentially based on the use of cholinesterase inhibitors that together with a NMDA receptor antagonist have been approved by the FDA. Nevertheless, the use of these drugs in therapy has been reported ineffective accompanied with temporary sympomatic benefits. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  

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