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1.
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16 p, 5.9 MB |
Adipokines as New Biomarkers of Immune Recovery : Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy
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Yeregui, Elena (Instituto de Salud Carlos III) ;
Masip, J. (Instituto de Salud Carlos III) ;
Viladés, C. (Instituto de Salud Carlos III) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Y.M. (Universidad de Sevilla) ;
Blanco, J. (Universitat de Vic - Universitat Central de Catalunya) ;
Mallolas Masferrer, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alba, Verónica (Instituto de Salud Carlos III) ;
Vargas, M. (Instituto de Salud Carlos III) ;
García-Pardo, G. (Instituto de Salud Carlos III) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Olona, M. (Instituto de Salud Carlos III) ;
Vidal-González, J. (Universitat de Barcelona) ;
Peraire, M. (Universitat Rovira i Virgili) ;
Martí, A. (Instituto de Salud Carlos III) ;
Reverté, L. (Instituto de Salud Carlos III) ;
Gómez-Bertomeu, F. (Instituto de Salud Carlos III) ;
Leal, M. (Hospital Viamed Santa Ángela de la Cruz) ;
Vidal, F. (Instituto de Salud Carlos III) ;
Peraire, J. (Instituto de Salud Carlos III) ;
Rull, A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. [...]
2022 -  10.3390/ijms23042202
International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202
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2.
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11 p, 2.7 MB |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control
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Masip, Jenifer (Hospital Universitari Joan XXIII de Tarragona) ;
Rallón, Norma (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Yeregui, Elena (Hospital Universitari Joan XXIII de Tarragona) ;
Olona, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Resino, Salvador (Instituto de Salud Carlos III) ;
Benito, José M. (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Viladés, Consuelo (Instituto de Salud Carlos III) ;
García-Pardo, Graciano (Hospital Universitari Joan XXIII de Tarragona) ;
Alcami, Jose (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ruiz-Mateos, Ezequiel (Universidad de Sevilla) ;
Gómez-Bertomeu, Frederic (Hospital Universitari Joan XXIII de Tarragona) ;
Vargas, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Navarro, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Oteo, José A. (Hospital Universitario San Pedro) ;
Pineda, Juan A. (Unidad de Investigación Hospital Universitario de Valme) ;
Martí, Anna (Hospital Universitari Joan XXIII de Tarragona) ;
Alba, Verónica (Hospital Universitari Joan XXIII de Tarragona) ;
Vidal, Francesc (Instituto de Salud Carlos III) ;
Peraire, Joaquin (Instituto de Salud Carlos III) ;
Rull, Anna (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. [...]
2022 - 10.3389/fimmu.2022.822272
Frontiers in immunology, Vol. 13 (april 2022)
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3.
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4.
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14 p, 1.5 MB |
The Toronto Mindfulness Scale and the State Mindfulness Scale : psychometric properties of the Spanish versions
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Navarrete Hidalgo, Jaime (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Fontana-McNally, Marta (Parc Sanitari Sant Joan De Déu) ;
Colomer-Carbonell, Ariadna (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sanabria-Mazo, Juan P.. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Pinazo, Daniel (Universitat Jaume I. Departament de Psicologia Evolutiva, Educativa, Social i Metodologia) ;
Silvestre-López, Antonio-José (Universitat Jaume I. Departament en Estudis anglesos) ;
Lau, Mark (University of British Columbia. Department of Psychiatry) ;
Tanay, Galia (University of Haifa. Observing Minds Lab) ;
Garcia-Campayo, Javier (Universidad de Zaragoza) ;
Demarzo, Marcelo (Universidade Federal de São Paulo (Brazil)) ;
Soler, Joaquim (CIBER of Mental Health (CIBERSAM)) ;
Cebolla Marti, Ausias (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Feliu-Soler, Albert (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ;
Luciano, Juan V (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
The Toronto Mindfulness Scale (TMS) and the State Mindfulness Scale (SMS) are two relevant self-report measures of state mindfulness. The purpose of this study was to examine the internal structure and to offer evidence of the reliability and validity of the Spanish versions of the TMS and SMS. [...]
2023 - 10.3389/fpsyg.2023.1212036
Frontiers in psychology, Vol. 14 (july 2023)
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5.
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13 p, 2.2 MB |
High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5 : Prognostic signature of immune recovery status in treated HIV-positive patients
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Yeregui, Elena (Institut d'Investigació Sanitària Pere Virgili) ;
Viladés, Consuelo (Institut d'Investigació Sanitària Pere Virgili) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Ceausu, Andra (Universitat Rovira i Virgili) ;
Pacheco, Yolanda María (Universidad de Sevilla) ;
Veloso, Sergi (Universitat Rovira i Virgili) ;
Inciarte, Alexy (Hospital Clínic i Provincial de Barcelona) ;
Vidal-González, Judit (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peraire, Maria (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Perpiñán, Carles (CAP Sant Pere) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Masip, Jenifer (Universitat Rovira i Virgili) ;
Alba Elvira, Veronica (Universitat Rovira i Virgili) ;
Vargas Laguna, Montserrat (Universitat Rovira i Virgili) ;
Martí, Anna (Universitat Rovira i Virgili) ;
Reverté Calvet, Laia (Universitat Rovira i Virgili) ;
Mallolas Masferrer, Josep (Hospital Clínic i Provincial de Barcelona) ;
Vidal, Francesc (Universitat Rovira i Virgili) ;
Peraire, Joaquim (Universitat Rovira i Virgili) ;
Rull, Anna (Universitat Rovira i Virgili) ;
Universitat Autònoma de Barcelona
The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4 T-cell turnover. [...]
2020 - 10.1016/j.ebiom.2020.103077
EBioMedicine, Vol. 62 (december 2020) , p. 103077
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6.
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11 p, 654.5 KB |
Meditators' Non-academic Definition of Mindfulness
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Alvear, David (Universidad del País Vasco) ;
Soler, Joaquim (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cebolla Marti, Ausias (Universitat de València) ;
Universitat Autònoma de Barcelona
Mindfulness has been defined differently in academic scientific contexts and in Buddhist academic contexts. An under-studied area is that of lay (non-academic) theories of mindfulness. The goal of this article is to identify, organize, analyze in detail, and provide themes from the meditators' definitions of mindfulness. [...]
2022 - 10.1007/s12671-022-01899-3
Mindfulness, may 2022, p. 1-11
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25 p, 6.3 MB |
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Arias-Sardá, Cristina (University of Kent. School of Biosciences) ;
Montes-Espuña, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lister, Nicholas C. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Cuartero, Yasmina (Centre de Regulació Genòmica) ;
García, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Deakin, Janine (University of Canberra. Institute for Applied Ecology) ;
Renfree, Marilyn B. (The University of Melbourne. School of Biosciences) ;
Robinson, Terence J. (Stellenbosch University. Department of Botany and Zoology) ;
Martí-Renom, Marc A. (Centre de Regulació Genòmica) ;
Waters, Paul D. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Farré, Marta (University of Kent. School of Biosciences) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. [...]
2022 - 10.1016/j.celrep.2022.111839
Cell reports, Vol. 41, Issue 12 (December 2022) , art. 111839
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8.
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20 p, 10.7 MB |
The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
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Jimenez-Panizo, Alba (National Cancer Institute. National Institutes of Health) ;
Alegre-Martí, Andrea (Universitat de Barcelona. Institut de Biomedicina) ;
Tettey, Theophilus T. (National Cancer Institute. National Institutes of Health) ;
Fettweis, Gregory (National Cancer Institute. National Institutes of Health) ;
Abella, Montserrat (Universitat de Barcelona. Institut de Biomedicina) ;
Antón, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Johnson, Thomas A. (National Cancer Institute. National Institutes of Health) ;
Kim, Sohyoung (National Cancer Institute. National Institutes of Health) ;
Schiltz, R. Louis (National Cancer Institute. National Institutes of Health) ;
Núñez-Barrios, Israel (Centro Andaluz de Biología del Desarrollo. Universidad Pablo de Olavide) ;
Font-Díaz, Joan (Universitat de Barcelona. Facultat de Biologia. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Caelles, Carme (Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació. Departament de Bioquímica i Fisiologia) ;
Valledor, Annabel F. (Universitat de Barcelona. Facultat de Biologia. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Perez, Paloma (Instituto de Biomedicina de Valencia (IBV-CSIC)) ;
Rojas, Ana M. (Centro Andaluz de Biología del Desarrollo. Universidad Pablo de Olavide) ;
Fernández-Recio, Juan (Universidad de La Rioja. Instituto de Ciencias de la Vid y del Vino) ;
Presman, Diego M. (IFIBYNE. UBA-CONICET. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales) ;
Hager, Gordon L. (National Cancer Institute. National Institutes of Health) ;
Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Estebanez-Perpiñá, Eva (Universitat de Barcelona. Institut de Biomedicina)
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, the functional oligomeric state of the full-length receptor, which is essential for its transcriptional activity, remains disputed. [...]
2022 - 10.1093/nar/gkac1119
Nucleic acids research, Vol. 50 Núm. 22 (september 2022) , p. 13063-13082
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9.
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17 p, 534.5 KB |
COAST : An Open-Label, Phase II, Multidrug Platform Study of Durvalumab Alone or in Combination with Oleclumab or Monalizumab in Patients with Unresectable, Stage III Non-Small-Cell Lung Cancer
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Herbst, Roy S. (Yale Cancer Center. Smilow Cancer Hospital) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Barlesi, Fabrice (Gustave Roussy) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Chu, Quincy (Cross Cancer Institute) ;
Monnet, Isabelle (Centre Hospitalier Intercommunal de Créteil) ;
Sánchez Hernández, Alfredo (Consorci Hospitalari Provincial de Castelló) ;
Dakhil, Shaker (Cancer Center of Kansas) ;
Camidge, D (University of Colorado Anschutz Medical Campus) ;
Winzer, Leanne (AstraZeneca) ;
Soo-Hoo, Yee (AstraZeneca) ;
Cooper, Zachary A. (AstraZeneca) ;
Kumar, Rakesh (AstraZeneca) ;
Bothos, John (AstraZeneca) ;
Aggarwal, Charu (Abramson Cancer Center. University of Pennsylvania) ;
Martinez-Marti, Alex (Vall d'Hebron Institut d'Oncologia)
PURPOSEDurvalumab significantly improves overall survival for patients with unresectable stage III non-small-cell lung cancer and no progression after concurrent chemoradiotherapy (cCRT). Building upon that standard of care, COAST is a phase II study of durvalumab alone or combined with the anti-CD73 monoclonal antibody oleclumab or anti-NKG2A monoclonal antibody monalizumab as consolidation therapy in this setting. [...]
2022 - 10.1200/JCO.22.00227
Journal of Clinical Oncology, Vol. 3 (january 2022) , p. JCO.22.00227
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10.
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16 p, 1.5 MB |
Molecular Detection and Epidemiology of Potentially Zoonotic Cryptosporidium spp. and Giardia duodenalis in Wild Boar (Sus scrofa) from Eastern Spain
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Martí-Marco, Alba (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Moratal, Samantha (Universidad CEU Cardenal Herrera. Servicio de Análisis, Investigación, Gestión de Animales Silvestres) ;
Torres-Blas, Irene (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Cardells-Peris, Jesús (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Lizana, Victor (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Dea-Ayuela, M. Auxiliadora (Universidad CEU Cardenal Herrera. Departamento de Farmacia)
Cryptosporidium spp. and Giardia duodenalis are widely distributed pathogens in vertebrates. Both protozoa are among the major causes of diarrhoea in humans. Wild boars are known hosts of both parasites and are able to harbour zoonotic species. [...]
2023 - 10.3390/ani13152501
Animals, Vol. 13 (august 2023)
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